An optofluidic "tweeze-and-drag" cell stretcher in a microfluidic channel.

The mechanical properties of biological cells are utilized as an inherent, label-free biomarker to indicate physiological and pathological changes of cells. Although various optical and microfluidic techniques have been developed for cell mechanical characterization, there is still a strong demand for non-contact and continuous methods. Here, by combining optical and microfluidic techniques in a single desktop platform, we demonstrate an optofluidic cell stretcher based on a "tweeze-and-drag" mechanism using a periodically chopped, tightly focused laser beam as an optical tweezer to trap a cell temporarily and a flow-induced drag force to stretch the cell in a microfluidic channel transverse to the tweezer.

Photoresponsive spiro-polymers generated in situ by C-H-activated polyspiroannulation.

The development of facile and efficient polymerizations toward functional polymers with unique structures and attractive properties is of great academic and industrial significance. Here we develop a straightforward C-H-activated polyspiroannulation route to in situ generate photoresponsive spiro-polymers with complex structures. The palladium(II)-catalyzed stepwise polyspiroannulations of free naphthols and internal diynes proceed efficiently in dimethylsulfoxide at 120 °C without the constraint of apparent stoichiometric balance in monomers.

Optical lattice generation using vertically embedded multimode-interference square-core polymer waveguides on a silicon chip.

We demonstrate two-dimensional optical lattice generation at 1064nm wavelength using vertically embedded multimode-interference (MMI) square-core polymer waveguides on a silicon chip. We demonstrate tuning of the effective waveguide length by longitudinally offsetting the waveguide input end-face from the input beam waist. Our measurement results of the waveguides with different cross-sectional dimensions at different effective waveguide lengths exhibit lattice patterns spanning from 4 × 4 to 10 × 10 arrays at the waveguide output end-face.

Silicon coupled-resonator optical-waveguide-based biosensors using light-scattering pattern recognition with pixelized mode-field-intensity distributions.

Chip-scale, optical microcavity-based biosensors typically employ an ultra-high-quality microcavity and require a precision wavelength-tunable laser for exciting the cavity resonance. For point-of-care applications, however, such a system based on measurements in the spectral domain is prone to equipment noise and not portable. An alternative microcavity-based biosensor that enables a high sensitivity in an equipment-noise-tolerant and potentially portable system is desirable.