Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air-liquid interface.

Fine particulate matter (PM) can enter the human body in various ways and have adverse effects on human health. Human lungs and eyes are exposed to the air for a long time and are the first to be exposed to PM. The "liquid immersion exposure method" has some limitations that prevent it from fully reflecting the toxic effects of particulate matter on the human body.

Acute exposure to seasonal PM induces toxicological responses in A549 cells cultured at the air-liquid interface mediated by oxidative stress and endoplasmic reticulum stress.

Atmospheric fine particulate matter (PM) enters the human body through respiration and poses a threat to human health. This is not only dependent on its mass concentration in the atmosphere, but also related to seasonal variations in its chemical components, which makes it important to study the cytotoxicity of PM in different seasons. Traditional immersion exposure cannot simulate the living environment of human epithelial cells in the human body, making this method unsuitable for evaluating the inhalation toxicity of PM.

The Cytotoxic Effects of Fine Particulate Matter (PM) from Different Sources at the Air-Liquid Interface Exposure on A549 Cells.

The health of humans has been negatively impacted by PM exposure, but the chemical composition and toxicity of PM might vary depending on its source. To investigate the toxic effects of particulate matter from different sources on lung epithelial cells (A549), PM samples were collected from residential, industrial, and transportation areas in Nanjing, China. The chemical composition of PM was analyzed, and toxicological experiments were conducted.

Chemical Composition and Transgenerational Effects on of Seasonal Fine Particulate Matter.

While numerous studies have demonstrated the adverse effects of fine particulate matter (PM) on human health, little attention has been paid to its impact on offspring health. The multigenerational toxic effects on () were investigated by acute exposure. PM and PM samples were collected and analysed for their chemical composition (inorganic ions, metals, OM, PAHs) in different seasons from April 2019 to January 2020 in Lin'an, China.

Ecotoxicity induced by total, water soluble and insoluble components of atmospheric fine particulate matter exposure in Caenorhabditis elegans.

Although PM could cause toxicity in environmental organisms, the toxicity difference of PM under different solubilities is still poorly understood. To acquire a better knowledge of the ecotoxicity of PM under different solubilities, the model animal Caenorhabditis elegans (C. elegans) was exposed to Total-PM, water insoluble components of PM (WIS-PM) and water soluble components of PM (WS-PM).