In vitro and in vivo comparative study of a novel Ga-labeled PSMA-targeted inhibitor and Ga-PSMA-11.

Ga-radiolabeled small molecules that specifically target prostate-specific membrane antigen (PSMA) have been extensively investigated, and some of these tracers have been used in the diagnosis of prostate cancer via Ga-positron emission tomography (Ga-PET). Nevertheless, current Ga-labeled radiotracers show only fair detection rates for metastatic prostate cancer lesions, especially those with lower levels of prostate specific antigen (PSA), which often occurs in the biochemical recurrence of prostate cancer. The goal of this study was to design and synthesize a new PSMA-targeted radiotracer, Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics.

Characterization of laser-induced air plasmas by third harmonic generation.

Third harmonic generation by a weak femtosecond probe pulse intersecting a pump laser-induced plasma in air is investigated and a general model is developed to describe such signal, applicable to a wide range of focusing and plasma conditions. The effect of the surrounding air on the generated signal is discussed. The third-order nonlinear susceptibility of an air plasma with electron density N(e) is determined to be χ(p)((3)) = χ(a)((3)) + γ(p)N(e) with γ(p) = 2 ± 1 × 10(-49) m(5) V(-2) and χ(a)((3)) being the third-order susceptibility in air.

Determination of the transient electron temperature in a femtosecond-laser-induced air plasma filament.

The transient electron temperature in a weakly ionized femtosecond-laser-produced air plasma filament was determined from optical absorption and diffraction experiments. The electron temperature and plasma density decay on similar time scales of a few hundred picoseconds. Comparison with plasma theory reveals the importance of inelastic collisions that lead to energy transfer to vibrational degrees of freedom of air molecules during the plasma cooling.

Surface plasmon resonance sensor based on polarization interferometry and angle modulation.

A surface plasmon resonance (SPR) sensing technique based on polarization interferometry and angle modulation is presented. Its sensitivity is not a direct function of variation of reflection intensity, nor of phase shift. Rather, it is a function of the complex reflection coefficient.