Persistent chemiluminescence-based nanosensor for portable point-of-care testing of HO.

A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of HO in food. CuSe nanoparticles (CuSe) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSe@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of HO.

Endogenous glucose-driven cascade reaction of nano-drug delivery for boosting multidrug-resistant bacteria-infected diabetic wound healing.

Multidrug-resistant (MDR) bacteria-infected wound healing remains greatly challenging, especially in diabetic patients. Herein, a novel nano-drug delivery based on endogenous glucose-driven cascade reaction is proposed for boosting MDR bacteria-infected diabetic wound healing with high efficacy by improving wound microenvironment and enhancing photodynamic antibacterial activity. The composite nanoagent is first self-assembled by integrating berberine (BBR) and epigallocatechin gallate (EGCG) from natural plant extracts, named as BE, which is successively coated with manganese dioxide nanoshells (MnO) and glucose oxidase (GOX) to form the final BEMG.

Reusable and self-sterilization mask for real-time personal protection based on sunlight-driven photocatalytic reaction.

Personal protective masks play critical role in preventing the disease epidemic and resisting pathogenic bacterial infestation. However, large quantities of masks were disposed during COVID-19 epidemic, which caused environmental problem and huge economic burden. Herein, we developed reusable masks with inherent antimicrobial and self-cleaning features under solar irradiation.

A cerium-based fluorescent nanosensor for highly specific detection of glutathione over cysteine and homocysteine.

Ever-increasing attention has been focused on constructing a sensing system for specific detection of glutathione (GSH) over cysteine (Cys) and homocysteine (Hcy), which usually interfere with the GSH detection due to their similar structures and the presence of thiol groups in these amino acids. Here, a novel fluorescence-sensing system is developed for highly specific GSH detection over Cys and Hcy. The sensing system is constructed through facilely mixing dipicolinic acid (DPA) and guanosine 5'-monophosphate (GMP) with cerium acetate at ambient conditions, denoted as DPA-Ce-GMP.

Smartphone-based enzyme-free fluorescence sensing of organophosphate DDVP.

A novel fluorescence strategy based on the outstanding catalytic capability of CuS nanoparticles (CuS) has been developed for highly sensitive and specific determination of o,o-dimethyl-o-2,2-dichlorovinyl phosphate (DDVP) under enzyme-free and hydrogen peroxide (HO)-free conditions. In the presence of DDVP, CuS can catalyze non-fluorescence substratum of Amplex red (AR) into resorufin, which exhibits fluorescence emission at 584 nm under excitation at 540 nm. The sensing system exhibits outstanding specificity and only responds to DDVP and no other organophosphorus pesticides (OPs).

Dual stimuli-responsive lanthanide-based phosphors for an advanced full-color anti-counterfeiting system.

Dual stimuli-responsive lanthanide (Ln)-based phosphors were prepared for constructing a multi-level full color anti-counterfeiting system. The encrypted information can be visually read out under UV irradiation. Further triggered by water, not only are the fluorescence colors changed, but so are the patterns of the encrypted information.

A smartphone-integrated ratiometric fluorescence sensing platform for visual and quantitative point-of-care testing of tetracycline.

A smartphone-integrated ratiometric fluorescent sensing system (DPA-Ce-GMP-Eu) for visual and point-of-care testing (POCT) of tetracycline with high sensitivity and accuracy was developed. The blue fluorescence of DPA-Ce-GMP was changed into red by doping with Eu duo to the energy transfer from Ce to Eu. Upon exposure to tetracycline, coordination between Eu and tetracycline blocks energy transfer from Ce to Eu, converting the fluorescent color from red to blue.

Arsenic Species Analysis at Trace Level by High Performance Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometry.

A sensitive and accurate simultaneous continuous analysis for six arsenic species including arsenobetaine (AsB), arsenocholine (AsC), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenite (As), and arsenate (As) has been developed by high performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). An anion-exchange column of Hamilton PRP-X100 (Switzerland) was applied for separation of the six arsenic species with gradient elution of 1.25 mmol/L NaHPO and 11.

Tumor-Microenvironment-Induced All-in-One Nanoplatform for Multimodal Imaging-Guided Chemical and Photothermal Therapy of Cancer.

Precisely locating tumor site based on tumor-microenvironment-induced (TMI) multimodal imaging is especially interesting for accurate and efficient cancer therapy. In the present investigation, a novel TMI all-in-one nanoplatform, CuS@DOX@MnO, has been successfully fabricated for chemical and photothermal (Chem-PTT) therapy guided by multimodal imaging on tumor site. Here, the CuS nanocages with mesoporous and hollow structure (CuS) acting as nanocarriers provide high capacity for loading the anticancer drug, doxorubicin (DOX).

A Asp/Ce nanotube-based colorimetric nanosensor for HO-free and enzyme-free detection of cysteine.

A novel colorimetric nanosensor has been developed for high sensitive and selective detection of cysteine (Cys) based on the intrinsic oxidase-like activity of cerium nanotube coordinated with aspartic acid (Asp/Ce-NT). Under the function of Asp/Ce-NT, colorimetric reaction of TMB (3,3',5,5'-tetramethylbenzidine) takes place within five minutes without the assistance of additional oxidizing agents (e.g.

A MnO nanosheet-based ratiometric fluorescent nanosensor with single excitation for rapid and specific detection of ascorbic acid.

Ascorbic acid (AA) detection in biological sample and food sample is critical for human health. Herein, a MnO nanosheet (MnO-NS)-based ratiometric fluorescent nanosensor has been developed for high sensitive and specific detection of AA. The MnO-NS presents peroxidase-like activity and can oxidize non-fluorescent substrate of o-phenylenediamine (OPDA) into fluorescent substrate, presenting maximum fluorescence at 568 nm (F).

An Ultrasensitive Fluorescence Sensor with Simple Operation for Cu Specific Detection in Drinking Water.

Whether short-term or long-term, overexposure to an abnormal amount of copper ion does significant harm to human health. Considering its nonbiodegradability, it is critical to sensitively detect copper ion. Herein, a novel fluorescent strategy with a "turn-on" signal was developed for highly sensitive and specific detection of copper ion (Cu).

A target-induced logically reversible logic gate for intelligent and rapid detection of pathogenic bacterial genes.

For the first time, a target (pathogenic bacterial gene)-induced logically reversible logic gate was constructed as an intelligent biosensor, which has one-to-one mapping functionality and can rapidly distinguish all information of the two targets, the presence of any target and the absence (or presence) of both of the targets, from the unique output signal pattern.

Nanozyme-based bio-barcode assay for high sensitive and logic-controlled specific detection of multiple DNAs.

Since HCV and HIV share a common transmission path, high sensitive detection of HIV and HCV gene is of significant importance to improve diagnosis accuracy and cure rate at early stage for HIV virus-infected patients. In our investigation, a novel nanozyme-based bio-barcode fluorescence amplified assay is successfully developed for simultaneous detection of HIV and HCV DNAs with excellent sensitivity in an enzyme-free and label-free condition. Here, bimetallic nanoparticles, PtAu, present outstanding peroxidase-like activity and act as barcode to catalyze oxidation of nonfluorescent substrate of amplex red (AR) into fluorescent resorufin generating stable and sensitive "Turn On" fluorescent output signal, which is for the first time to be integrated with bio-barcode strategy for fluorescence detection DNA.