Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.

Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.

Characteristics of Salivary Iodine Concentration in Elderly Residents of High-iodine Areas.

Salivary iodine is considered a potential indicator for assessing iodine nutrition status. However, there is currently a lack of research data on the characteristics of salivary iodine concentration (SIC) in the elderly population. To evaluate the characteristics of SIC and assess its efficacy in diagnosing thyroid disorders among the elderly population, a cross-sectional study was conducted in a high-iodine area.

Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly.

The relationship between high water iodine levels and thyroid dysfunction in the elderly remains poorly understood. This study aimed to elucidate how excessive iodine in drinking water affects iodine nutrition and thyroid function in the elderly population. This cross-sectional study was performed in the elderly in Yuncheng, Heze, Shandong.

Structure of AcrVIA2 and its binding mechanism to CRISPR-Cas13a.

Phages and non-phage derived bacteria have evolved many anti-CRISPR proteins (Acrs) to escape the adaptive immune system of prokaryotes. Thus Acrs can be applied as a regulatory tool for gene edition by CRISPR system. Recently, a non-phage derived AcrVIA2 has been identified as an inhibitor that blocks the editing activity of Cas13a in vitro by binding to Cas13a.