Publications by authors named "Zhangyue Guan"
Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C.
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- Infections from azole-resistant Candida tropicalis are rising in healthcare settings, but the reasons and mechanisms behind this resistance remain unclear.
- This study analyzed 239 strains of C. tropicalis from both environmental and human sources, finding that most had a diploid genome and exhibited similar survival and enzyme production capabilities.
- Resistant strains were identified in nearly 20% of both groups, with certain genetic mutations linked to azole resistance, suggesting a close genetic relationship between environmental and human isolates.
Article Synopsis
- * Research indicates that low RH triggers same-sex mating and mating projection development in the human fungal pathogen Candida albicans by inducing osmotic stress and the production of reactive oxygen species (ROS).
- * The study identifies key components involved in this process, namely the cell surface sensors Aqy1 and Gpr1, trehalose, and specific signaling pathways (Hog1-osmotic and Hsf1-Hsp90), highlighting their role in regulating mating in low humidity conditions.
Candida auris is an emerging multidrug-resistant fungal pathogen and a new global threat to human health. A unique morphological feature of this fungus is its multicellular aggregating phenotype, which has been thought to be associated with defects in cell division. In this study, we report a new aggregating form of two clinical C.
View Article and Find Full Text PDFThe diploid fungal pathogen Candida albicans has three configurations at the mating type locus (MTL): heterozygous (a/α) and homozygous (a/a or α/α). C. albicans MTL locus encodes four transcriptional regulators (MTLa1, a2, α1, and α2).
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