Publications by authors named "Zhangxin Ji"
Article Synopsis
- Type 2 diabetes mellitus (T2DM) can cause multi-organ complications, particularly in the liver, and Gegen Qinlian Decoction (GQD) shows promise in managing these issues according to modern Chinese medicine.
- The study aimed to investigate how GQD improves liver injury in T2DM through various experimental methods including UPLC analysis and animal models.
- Results indicated that GQD enhances liver function, reduces oxidative stress and lipid peroxidation, and alleviates iron overload, suggesting it helps protect against liver injury by inhibiting ferroptosis via Nrf2 modulation.
Article Synopsis
- Diabetes mellitus (DM) is a chronic metabolic condition that can lead to kidney damage, and Di'ao XinXueKang (DXXK) is a new herbal treatment used to combat both DM and kidney issues, though its exact mechanism of action is not fully understood.
- Researchers utilized network pharmacology, molecular docking, and animal studies to investigate how DXXK affects diabetic kidney injury, finding key ingredients like dioscin and protodioscin that interact with critical targets involved in the disease.
- The study concluded that DXXK effectively reduces diabetic symptoms and kidney damage in mice, primarily by modulating important signaling pathways related to DM, such as the TGF-beta pathway.
Obesity is a multifactorial chronic metabolic disease with multiple complications. (CP) and (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD).
View Article and Find Full Text PDFBackground: Diabetes that only appears or is diagnosed during pregnancy is referred to as gestational diabetes mellitus (GDM). The maternal physiological immune profile is essential for a positive pregnancy outcome. However, the causal relationship between GDM and immunophenotypes is not fully defined.
View Article and Find Full Text PDFBackground: Activated neutrophils release depolymerized chromatin and protein particles into the extracellular space, forming reticular Neutrophil Extracellular Traps (NETs). This process is accompanied by programmed inflammatory cell death of neutrophils, known as NETosis. Previous reports have demonstrated that NETosis plays a significant role in immune resistance and microenvironmental regulation in cancer.
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