Publications by authors named "Zhangwen Lei"
Article Synopsis
- The heart uses various defense mechanisms, including metabolic plasticity, to function properly in low-oxygen environments like high altitudes, and pioglitazone, a PPARγ agonist, appears to play a significant role in this.
- In a study with hypoxic mice, pioglitazone was shown to prevent cardiac dysfunction for four weeks, enhancing heart muscle contraction and reducing QT interval prolongation without relying on its effects on insulin sensitivity.
- The drug also improved cardiac glucose metabolism by increasing glycolysis, glucose oxidation, and ATP production while promoting the expression of HIF-1α; however, inhibiting HIF-1α hindered these metabolic benefits and reduced heart function.
Objective The goal is to determine the best location for inserting a catheter into the aortic arch of patients with a certain type of aortic dissection (DeBakey type I) by analyzing images of the patient's aortic arch before surgery. This analysis will take into account the shape and structure of the patient's aortic arch to find the most optimal location for cannulation. Methods A retrospective analysis was conducted on 100 patients with acute DeBakey type I aortic dissection diagnosed between January 2021 and February 2023, utilizing the Carestream medical imaging software Image Suite V4 (New York, USA).
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