Publications by authors named "Zhangmin Liu"

Article Synopsis
  • Scientists studied if moving a certain nerve from the index finger to repair a damaged thumb nerve would work well.
  • They treated 23 patients who had thumb injuries caused by things like machines or sharp objects, and most of them healed well after the surgery.
  • The results showed that this method helped people feel better in their thumbs, making it a good option for thumb nerve repair.
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Valienone is a significant natural carbasugar member of the C7-cyclitol family as a valuable precursor for glycosidase inhibitor drugs. It is an intermediate of validamycin A biosynthesis pathway and exhibits minimal accumulation in the fermentation broth of the natural Streptomyces producer. A quantitative analytical method is crucial for the development of a breakthrough microbial process overcoming the consumption of the natural metabolic flux.

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Valienamine and β-valienamine are representative C N aminocyclitols with significant glycosidase inhibition activity that have been developed as important precursors of drugs for diabetes and lysosomal storage diseases, respectively. The quantitative analysis of these chiral compounds is crucial for asymmetric in vitro biosynthetic processes for converting valienone into valienamine epimers using aminotransferase. Here, we developed an efficient and sensitive method for separation and quantitative analysis of chiral valienamine using reversed-phase high-performance liquid chromatography (HPLC) through o-phthalaldehyde (OPA) pre-column derivatization of the analytes.

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Article Synopsis
  • The study aimed to evaluate the therapeutic effects of treating collapsed and comminuted distal radius fractures in 26 hospitalized patients from 1998 to 2003.
  • The treatment involved open reduction, sustained bone grafting, and the use of a joint external fixator, which helped restore the anatomical shape of the radius.
  • Results indicated successful fracture healing with no length discrepancies, intact joint surfaces, and a majority rated as excellent or good based on the Dieust criterion.
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