Bifuruzan skeleton: developing new high-energy and high-density energetic materials.

Context: High-energy density materials (HEDMs) are integral to modern society and are in high demand. Consequently, the design and synthesis of energetic material molecules have garnered significant research interest. This study focuses on the furazan ring system as a core for developing superior HEDMs.

PD-1/PD-L1 immune checkpoint inhibitors in the treatment of unresectable locally advanced or metastatic triple negative breast cancer: a meta-analysis on their efficacy and safety.

Background: Triple negative breast cancer (TNBC) represents a particularly aggressive and clinically challenging subtype of breast cancer, characterized by its invasive nature and generally poor prognosis. Treatment options for unresectable TNBC are limited. In recent years, the advent of PD-1/PD-L1 immune checkpoint inhibitors has offered a promising new treatment option for unresectable TNBC.

Electrochemical sensor for hydrogen sulfide detection using electrocatalysis-assisted amplification and chemical reaction-mediated signal enhancement.

An ultrasensitive electrochemical biosensing platform has been designed by combining electrocatalysis-assisted HS amplification with a chemical reaction-mediated electrochemical signal-boosted system for HS detection based on Cu-Mn(OH) hexagonal nanorings. The signal amplification is initiated by an electrocatalysis reaction that can grasp specific HS substrates and further highly amplify electrochemical signals. Then, the unique chemical reaction is powered by copper ion and generates a large amount of electroactive CuS products on the electrode surface, thus achieving the multiple amplification of HS detection.

Identification and whole-genome sequencing analysis of Vibrio vulnificus strains causing pearl gentian grouper disease in China.

Vibrio vulnificus is a pathogenic bacterium that causes disease in marine fish, affecting fish farming and human health worldwide. In May 2021, in the Bohai Bay region, a disease broke out in commercially farmed pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus), causing huge economic losses. The diseased fish had skin lesions, water accumulation in their abdomens, and showed tissue and organ damage.