Publications by authors named "Zhangjingyi Jiang"
Article Synopsis
- Atherosclerosis involves a change in vascular smooth muscle cells (VSMCs) from a stable state to a more active, harmful state, which contributes to plaque development.
- Recent studies show that VSMCs can turn into macrophage-like and bone-forming cells, making them a significant part of atherosclerotic plaques.
- Researchers have developed a delivery system using nanoparticles to target and deliver microRNA-145 (miR-145) to VSMCs, which could help reduce plaque formation and halt disease progression, showing promising results in mouse models.
Atherosclerosis is an inflammatory disease characterized by plaques that can cause sudden myocardial infarction upon rupture. Such rupture-prone plaques have thin fibrous caps due to collagenase degradation, and a noninvasive diagnostic tool and targeted therapy that can identify and treat vulnerable plaques and may inhibit the onset of acute cardiac events. Toward this goal, monocyte-binding, collagenase-inhibiting, and gadolinium-modified peptide amphiphile micelles (MCG PAMs) are developed.
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