Publications by authors named "Zhang-Zhang Lan"
Article Synopsis
- CircRNA, specifically circPRDM5, plays a crucial role in gastric cancer development by influencing tumor properties and interactions with specific microRNAs and target genes.
- Research findings show that overexpression of circPRDM5 can inhibit growth, migration, invasion, and glucose metabolism in gastric cancer cells, while its depletion has the opposite effect.
- CircPRDM5 interacts with miR-485-3p, acting as a sponge, and regulates GCNT4 expression, suggesting its potential as a therapeutic target for gastric cancer treatment.
Mutation-based molecular diagnostics of autosomal dominant polycystic kidney disease (ADPKD) is complicated by genetic and allelic heterogeneity, large multi-exon genes, and duplication sequences of PKD1. Recently, targeted resequencing by pooling long-range polymerase chain reaction (LR-PCR) amplicons has been used in the identification of mutations in ADPKD. Despite its high sensitivity, specificity and accuracy, LR-PCR is still complicated.
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