Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection.

Background: Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection.

Methods: In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nano-carrier and Cy3-labeled single DNA (ssDNA) probe.

Biorthogonal Dynamical Quantum Phase Transitions in Non-Hermitian Systems.

By utilizing biorthogonal bases, we develop a comprehensive framework for studying biorthogonal dynamical quantum phase transitions in non-Hermitian systems. With the help of the previously overlooked associated state, we define the automatically normalized biorthogonal Loschmidt echo. This approach is capable of handling arbitrary non-Hermitian systems with complex eigenvalues and naturally eliminates the negative value of Loschmidt rate obtained without the biorthogonal bases.

DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.

DExD/H-box helicases are crucial regulators of RNA metabolism and antiviral innate immune responses; however, their role in bacteria-induced inflammation remains unclear. Here, we report that DDX5 interacts with METTL3 and METTL14 to form an m6A writing complex, which adds N6-methyladenosine to transcripts of toll-like receptor (TLR) 2 and TLR4, promoting their decay via YTHDF2-mediated RNA degradation, resulting in reduced expression of TLR2/4. Upon bacterial infection, DDX5 is recruited to Hrd1 at the endoplasmic reticulum in an MyD88-dependent manner and is degraded by the ubiquitin-proteasome pathway.

Effectiveness and safety of angiotensin receptor-neprilysin inhibitor and sodium-glucose cotransporter-2 inhibitors for patients with heart failure with reduced ejection fraction: a meta-analysis.

The current review aimed to study the effectiveness and safety of angiotensin receptor-neprilysin inhibitor (ARNI) combined with sodium-glucose cotransporter-2 (SGLT2) inhibitors versus ARNI or SGLT2 inhibitors monotherapy in patients with heart failure with reduced ejection fraction (HFrEF). Studies containing patients with HFrEF who used ARNI combined with SGLT2 inhibitors versus ARNI or SGLT2 inhibitors alone were retrieved from the Medline, Embase, and Cochrane Library databases. From the selected studies, the pooled risk ratios with 95% confidence intervals of dichotomous outcomes were assessed by a random or fixed effects model in our meta-analysis.

Understanding the Quantum Rabi Ring Using Analogies to Quantum Magnetism.

We map a quantum Rabi ring, consisting of N cavities arranged in a ring geometry, into an effective magnetic model containing the XY exchange and the Dzyaloshinskii-Moriya (DM) interactions. The analog of the latter is induced by an artificial magnetic field, which modulates photon hopping between nearest-neighbor cavities with a phase. This mapping facilitates the description and understanding of the different phases in the quantum optical model through simple arguments of competing magnetic interactions.

Quantum Phases in a Quantum Rabi Triangle.

The interplay of interactions, symmetries, and gauge fields usually leads to intriguing quantum many-body phases. To explore the nature of emerging phases, we study a quantum Rabi triangle system as an elementary building block for synthesizing an artificial magnetic field. We develop an analytical approach to study the rich phase diagram and the associated quantum criticality.

Adverse Events of Sacubitril/Valsartan: A Meta-analysis of Randomized Controlled Trials.

This review aimed to summarize the adverse events (AEs) reported during the use of sacubitril/valsartan versus angiotensin converting enzyme inhibitors (ACEI)/angiotensin II receptor blocker (ARB). Studies containing safety outcomes or AEs during the use of sacubitril/valsartan versus ACEI/ARB were retrieved from the MEDLINE, Embase, and Cochrane Library databases and clinical trials. From the selected studies, the pooled risk ratios with 95% confidence intervals of dichotomous outcomes were assessed by a random or fixed effects model in our meta-analysis.

[Effects of leaf extracts of on seed germination and seedling growth of ].

and are common plant species used for greening construction in arid and semi-arid region of Northwest China. In order to explore the feasibility of greening construction and ecological restoration by with , we exami-ned the allelopathic effects of five concentrations of aqueous leaf extracts of (0.025, 0.

Legacy and alternative flame retardants in typical freshwater cultured fish ponds of South China: Implications for evolving industry and pollution control.

The production and usage of polybrominated diphenyl ethers (PBDEs) has been gradually phased out and the application of alternative halogenated flame retardants (AHFRs) has been continuously increased. It is essential to understand how the evolving flame retardants industry has affected the occurrence and flux of legacy and alternative flame retardants so that better pollution control measures can be made accordingly. Air, rainwater, inflowing river water, pond water, pond sediment, fish feed, and fish collected from freshwater cultured fish ponds (FWCFPs) within the Pearl River Delta, South China were analyzed for PBDEs and AHFRs.

Selected antibiotics and current-use pesticides in riverine runoff of an urbanized river system in association with anthropogenic stresses.

Antibiotics and current-use pesticides are ubiquitous in the environment. It is important to figure out their spatial distribution under the influences of anthropogenic activities and transport from rivers to coastal oceans. To address this knowledge gap, the present study conducted quarterly sampling in eight main runoff outlets of the Pearl River, South China, and obtained total concentrations of antibiotics and current-use pesticides at 24-296 ng L.

Powerful harmonic charging in a quantum battery.

We consider a harmonic charging field as an energy charger for the quantum battery, which consists of an ensemble of two-level atoms. The charging of noninteracting atoms is completely fulfilled, which exhibits a substantial improvement over previous static charging fields. Involving the repulsive interactions of atoms, the fully charging is achieved with shorter charged period over the noninteracting case, yielding an advantage for the charging.

MicroRNA-9 enhanced radiosensitivity and its mechanism of DNA methylation in non-small cell lung cancer.

In order to improve the therapeutic effect of non-small cell lung cancer (NSCLC), it is critical to combine radiation and gene therapy. Our study found that the activation of microRNA-9 (miR-9) conferred ionizing radiation (IR) sensitivity in cancer cells. Furthermore, increased microRNA-9 promoter methylation level was observed after IR.

Isolation and identification of the umami peptides from shiitake mushroom by consecutive chromatography and LC-Q-TOF-MS.

Umami is critical to the taste of shiitake mushroom. To isolate and identify umami peptides, fractions from hydrolyzed dried shiitake mushroom were separated by ultrafiltration, gel filtration chromatography (GFC), and reversed-phase high-performance liquid chromatography (RP-HPLC). Separations were combined with sensory evaluations (grading and taste dilution analysis) and analysis of electronic tongue, which were used to identify the most umami component in shiitake mushroom.

Kinetics of 5-hydroxymethylfurfural formation in the sugar-amino acid model of Maillard reaction.

Background: As a potential health hazard, 5-hydroxymethylfurfural (HMF) has been detected in thermally processed foods high in sugar and amino acids. In order to analyze HMF quantitatively and investigate the kinetics of its formation, high-performance liquid chromatography was employed to determine the content of HMF in six sugar-amino acid thermal reaction models.

Results: In thermal reaction models, formation of HMF was significantly affected by sugar and amino acid composition, pH value and heating conditions.

Comparison of non-volatile umami components in chicken soup and chicken enzymatic hydrolysate.

Umami taste is an important part to the taste of chicken. To isolate and identify non-volatile umami compounds, fractions from chicken soup and hydrolysate were prepared and analyzed. Amino acids were analyzed by amino acid analyzer.

A comparison between oral chemotherapy combined with radiotherapy and radiotherapy for newly diagnosed glioblastoma: A systematic review and meta-analysis.

The prognosis of glioblastoma (GBM), a major subtype of grade IV glioma, is rather poor nowadays. The efficiency of chemotherapy serving as the adjunct to radiotherapy (RT) for treating GBM is still controversial. In this study, we aim to investigate the overall survival (OS) and progression-free survival (PFS) in patients with newly diagnosed GBM received RT plus chemotherapy or with RT alone.

[Studies on difference of chemical compositions in plant species of Tripterygium genus].

We studied the content of chemical compositions and correlation among species of Tripterygium genus by principal component analysis(PCA) and variance analysis(ANOVA), and we also studied the difference among the 3 species.Using [BMIm]PF6 ionic liquid-based ultrasonic-assisted extraction, we determined the contents of 11 compounds including wilforgine, wilforzine, triptophenolide, wilforine, triptoquinone A, triptolide, tripterin, egallocatechin, epigallocatechin, catechin, and epicatechin in 28 batches of the Tripterygium species by HPLC and PCA. Partial least squares analysis (PLS) and ANOVA were also performed to verify the results.

Determination of the Free Amino Acid, Organic Acid, and Nucleotide in Commercial Vinegars.

The selected taste-active compounds in several kinds of commercial vinegar including amino acids, organic acids, and nucleotides were determined by High Performance Liquid Chromatography (HPLC). The results showed that glutamine and alanine, which contribute the umami and sweet taste to the flavor of vinegar, are high in Taste Activity Value (TAV). Acetic acid is the major organic acid in vinegar, making up as much as 91.

A study of asymmetrical mixed-valent Mo-Mo complexes in the class III regime.

Three novel asymmetrical dimolybdenum dimers, [Mo(DAniF)](μ-OOCCOS) (DAniF = N,N'-di(p-anisyl)formamidinate) ([OO-OS]), [Mo(DAniF)](μ-SCCO) ([SS-OO]), and [Mo(DAniF)](μ-SSCCOS) ([SS-OS]), have been synthesized and characterized by either single-crystal X-ray crystallography or H NMR spectroscopy. The structural asymmetry for these compounds gives rise to a redox asymmetry, which enlarges the potential separation (ΔE) between the two [Mo] units. The mixed-valance (MV) species [OO-OS], [SS-OO] and [SS-OS], prepared by one-electron chemical oxidation of the neutral precursors, exhibit an intense and symmetrical intervalence charge transfer (IVCT) absorption band in the near-IR region, along with the high energy metal (δ) to ligand (π*) (ML) and ligand (π) to metal (δ) charge transfer (LMCT) absorptions.

Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla.

Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (1-3), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 7-9), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (10-12), together with seven known cantharimides (6, 13-18), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 1-14 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC50 values of 62, 42, 58, and 19 μM.

[Chemical constituents from Mylabris phalerata and their cytotoxic activity in vitro].

Ten compounds were isolated from Mylabris phalerata by using preparative HPLC and column chromatography over MCI gel. On the basis of physical-chemical properties, NMR and MS data analysis, the compounds were identified as 5'-[(1 R,2 R,3 S,6R)-1-hydroxymethyl-2-methyl-3,6-epoxycyclohexane-1,2-dicarboximide]- ethyl-2'-methyl-2'-butenoate (1),cantharidin (2), cyclo-(L-Pro-L-Ala) (3), cyclo-(R-Pro-R-Leu) (4), cyclo-(S-Pro-R-Leu) (5), cyclo-(D-Pro-L-Tyr) (6), indole-3-aldehyde (7), 3-indoleacetic acid (8), valerolactam (9), and 4-hydroxyphthalid (10).Compound 1 was a new compound, and compounds 2-10 were obtained from this genus for the first time.

ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis.

Background: The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of radiotoxicity.

Methods: Publications were identified through a search of the PubMed and Web of Science databases up to August 15, 2015.

Distinguishing the strength of electronic coupling for Mo2 -containing mixed-valence compounds within the Class III regime.

Two, symmetrical, mixed-valence (MV), complex cations-{[Mo2 (DAniF)3 ]2 (μ-oxamidate)}(+) (1(+) ) and {Mo2 (DAniF)3 ]2 (μ-dithiooxamidate)}(+) (2(+) ; DAniF=N,N'-di(p-anisyl)formamidinate)-are significantly differentiated in terms of electronic coupling between the two [Mo2 ] units. For 1(+) the intervalence (IV) charge-transfer band in the near-IR spectrum is truncated in half on the low-energy side as predicted for MV compounds at the Class II-III limit (2Hab /λ=1; for which Hab =electronic coupling matrix element and λ=reorganization energy). In contrast, the very strongly coupled analogue 2(+) , as indicated by 2Hab /λ=3.

Clinical and molecular characteristics of emerging hypervirulent Klebsiella pneumoniae bloodstream infections in mainland China.

Recently, the newly emerged hypervirulent Klebsiella pneumoniae strain (hvKP) has caused great concern globally, but the clinical features and molecular characteristics of bacteremia caused by hvKP are rarely reported in mainland China. Seventy patients with K. pneumoniae bacteremia were investigated to study the clinical features of hvKP infection from 2008 till 2012 in Beijing Chao-Yang Hospital.