Publications by authors named "Zhang Zhou"

Aims: To explore serum exosomal microRNAs (miRNAs) as risk biomarkers for early detection of cognitive impairment in type 2 diabetes mellitus (T2DM) patients.

Materials And Methods: This study included two phases: a discovery phase and a validation phase. To detect adipose tissue exosomal biomarkers for T2DM patients, small RNA sequencing was conducted on a discovery population consisting of six T2DM patients and five subjects with normal glucose tolerance.

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Molecular imprinting technology (MIT) stands out for its exceptional simplicity and customization capabilities and has been widely employed in creating artificial antibodies that can precisely recognize and efficiently capture target molecules. Concurrently, nanozymes have emerged as promising enzyme mimics in the biomedical field, characterized by their remarkable stability, ease of production scalability, robust catalytic activity, and high tunability. Drawing inspiration from natural enzymes, molecularly imprinted nanozymes combine the unique benefits of both MIT and nanozymes, thereby conferring biomimetic catalysts with substrate specificity and catalytic selectivity.

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Fish gut health is influenced by various factors, with the environment being a significant one. is a key aquaculture species in China, yet research on the impact of different aquaculture systems on its intestinal health remains limited. This study aims to explore the changes in intestinal morphology and gut microbiota of under two aquaculture systems.

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Chronic nonspecific low back pain (cNLBP) accounts for approximately 90% of low back pain cases, affecting 65-80% of the population and significantly impacting life quality and productivity. This condition also leads to substantial financial burden. Although there have been advancements, a comprehensive understanding of the underlying etiology of cNLBP remains elusive, resulting in less than optimal treatment outcomes.

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  • Adolescent idiopathic scoliosis (AIS) is a condition causing abnormal spinal curvature and deformities, and the effectiveness of conservative treatments like physiotherapeutic scoliosis-specific exercises (PSSE) combined with manual therapy (MT) is under investigation.
  • In a study with 31 AIS patients, the intervention group received combined PSSE and MT, leading to significant reductions in the Cobb angle and improvements in spinal mobility, movement capability, and quality of life compared to the control group, which only received PSSE.
  • The results suggest that combining PSSE with MT may effectively alleviate AIS symptoms and enhance quality of life, indicating the need for further research to confirm these findings.
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Background: Existing studies investigating the impact of serum calcium (Ca), phosphate (P), 25 hydroxyvitamin D (25[OH]D), and parathyroid hormone (PTH) levels on kidney function have produced inconsistent results. Further research is needed to establish the direct causal relationship between these factors and kidney function.

Methods: The study used genome-wide association study datasets for exposure and outcome, mainly derived from the UK Biobank and CKDGen Consortium, with sample sizes ranging from 3,310 to 480,699 individuals of European ancestry.

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  • The study identified potential biomarkers in cell-free DNA (cfDNA) marked by 5-hydroxymethylcytosine (5hmC) that can detect colorectal cancer (CRC) up to 36 months prior to clinical diagnosis using samples from the PLCO Cancer Screening Trial.
  • Research utilized 5hmC-seal assays and machine learning on cfDNA from 201 CRC cases and 401 controls, producing a predictive detection model with promising accuracy (AUC values around 77% in training and 73% in validation sets), outperforming traditional risk factor assessments.
  • The 5hmC biomarkers hold potential for a minimally invasive test to enhance early CRC detection, thereby improving patient
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  • Circulating tumor DNA (ctDNA) is a noninvasive biomarker that can help guide treatment in patients with metastatic non-small-cell lung cancer (NSCLC) when tissue samples are lacking.
  • A new next-generation sequencing panel called the 101-test was developed to detect variants in ctDNA from a large group of Chinese patients, demonstrating high sensitivity and accuracy.
  • The 101-test showed a 72.2% concordance with tissue samples for detecting targetable variants, with some patients identified through ctDNA testing alone, highlighting its potential as a valuable diagnostic tool.
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Purpose: This study explored potential categories of dyadic disease appraisal differences among patients hospitalized with chronic heart failure (CHF) in China and analyzed the main factors influencing these categories.

Methods: A survey was conducted using various tools and scales, including the Chinese version of the Memorial Heart Failure Symptom Appraisal Scale, Heart failure self-care index scale, Social Support Rating Scale, Zarit burden interview, and Self-rating anxiety scale. The data was collected from patients who were hospitalized with CHF in the cardiology department of one of two tertiary hospitals in Nanchong City, China.

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  • Bitterness is sensed through bitter taste receptors that are primarily found in the tongue, but also throughout the respiratory, cardiovascular, digestive, reproductive, and nervous systems.
  • Recent research indicates these receptors play a key role in regulating essential physiological processes and are significant in disease treatment strategies.
  • The paper reviews the structure, classification, and signaling pathways of bitter taste receptors, as well as their connection to various diseases and the potential of bitter taste receptor agonists for future research.
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New industrial parks, including fine chemical, medical manufacturers, etc., are emerging in modern cities in China, whereas their emissions and impacts have not been fully illuminated. In this study, ambient volatile organic compounds (VOCs) in Huizhou were measured in three functional zones, namely new industrial, roadside, and residential zones.

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Root system architecture (RSA) is of growing interest in implementing plant improvements with belowground root traits. Modern computing technology applied to images offers new pathways forward to plant trait improvements and selection through RSA analysis (using images to discern/classify root types and traits). However, a major stumbling block to image-based RSA phenotyping is image label noise, which reduces the accuracies of models that take images as direct inputs.

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  • A new mild synthesis method was developed to create medium-ring oxazepane and oxazocine compounds using aminomaleimides and alkyl amines without the need for a catalyst.
  • The process involves cleaving the C(sp)-N bond with the help of substrates and acidic additives, allowing for C-C and C-O bond formation through a cascade cyclization reaction at room temperature.
  • This method shows versatility with a broad range of starting materials, successfully producing 28 seven-membered and 8 eight-membered examples, as well as utilizing some natural products.
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  • A study compared cognitive characteristics between patients with mild autonomous cortisol secretion (MACS) and those with Cushing's syndrome (CS), finding both groups had cognitive impairments compared to those without adrenal issues.
  • No significant cognitive difference was observed between MACS and CS patients, but both showed increased risks of immediate memory impairment.
  • After adrenal surgery, patients with MACS showed notable improvements in cognitive functions over 12 months, while those receiving conservative treatment did not experience the same benefits.
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Bioremediation of PAHs-contaminated soil by immobilized enzymes is a promising technology. Nevertheless, the practical implementation of highly efficient enzymatic remediation remains confined to laboratory settings, with limited experience in full-scale applications. In this study, the extracellular enzymes from white rot fungi are fully applied to treat sites contaminated with PAHs by combining a new hydrogel microenvironment and a biopiling system.

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Volatile solid additives have emerged as a promising strategy for enhancing film morphology and promoting the power conversion efficiency (PCE) of organic solar cells (OSCs). Herein, a series of novel polycyclic aromatic additives with analogous chemical structures, including fluorene (FL), dibenzothiophene (DBT), and dibenzofuran (DBF) derived from crude oils, are presented and incorporated into OSCs. All these additives exhibit strong interactions with the electron-deficient terminal groups of L8-BO within the bulk-heterojunction OSCs.

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The increasing size of pre-trained language models has led to a growing interest in model compression. Pruning and distillation are the primary methods employed to compress these models. Existing pruning and distillation methods are effective in maintaining model accuracy and reducing its size.

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  • Polycyclic aromatic hydrocarbons (PAHs) are harmful pollutants linked to cancer and developmental issues, and white-rot fungi possess the capability to break down these substances.
  • The study focused on using immobilized Trametes versicolor to degrade benzo[a]pyrene in soil, testing the impact of different low molecular weight organic acids, particularly citric acid, on this process.
  • Results indicated that citric acid enhanced the fungus's performance, leading to a 43.7% removal rate of benzo[a]pyrene and promoting fungal growth and enzyme activity, suggesting its potential as a biostimulant in soil remediation efforts.
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Objective: To explore the structural and functional changes in cognition-related brain regions in patients with chronic low back pain (CLBP) at earlier ages, and explore the impact of the interaction between CLBP and age on the brain.

Methods: Seventy-six patients with CLBP were recruited and divided into "younger" age group (20-29 years, YA), "middle" age group (30-39 years, MA), and "older" age group (40-49 years, OA). All patients underwent functional magnetic resonance imaging (fMRI) as well as clinical psychological and pain-related symptoms assessments.

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Background: Many guidelines have recommended renin-angiotensin system inhibitors (RASI) as the first-line treatment for patients with chronic kidney disease (CKD). We studied RASI prescription trends from 2010 to 2019, and analyzed the characteristics associated with RASI prescription in Chinese hospitalized CKD patients.

Aim: To study the prescription of renin angiotensin system inhibitors in hospitalized patients with CKD in China.

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Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, posing challenges. Additionally, underrepresented tumor DNA fragments may go undetected during exponential amplification steps of traditional sequencing methods.

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