Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy.

Specific tumor-targeted gene delivery remains an unsolved therapeutic issue due to aberrant vascularization in tumor microenvironment (TME). Some bacteria exhibit spontaneous chemotaxis toward the anaerobic and immune-suppressive TME, which makes them ideal natural vehicles for cancer gene therapy. Here, we conjugated ZIF-8 metal-organic frameworks encapsulating eukaryotic murine interleukin 2 () expression plasmid onto the surface of VNP20009, an attenuated strain with well-documented anti-cancer activity, and constructed a TME-targeted delivery system named /ZIF-8@.

Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure.

This study aimed to investigate the impact of IL-35 on the prognosis of patients with HBV-ACLF. We recruited 69 patients with HBV-ACLF, 20 patients with chronic hepatitis B (CHB), 17 patients with liver cirrhosis (LC), and 20 healthy controls (HCs) from a regional infectious disease treatment center in China. Plasma levels of IL-35 at baseline were detected using ELISA.

Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT.

Background: The optimal second-line systemic treatment for metastatic colorectal cancer (mCRC) is inconclusive.

Methods: We searched PubMed, Web of Science, EMBASE, and Cochrane Library for RCTs comparing second-line systemic treatments for mCRC from the inception of each database up to February 3, 2024. Markov Chain Monte Carlo (MCMC) technique was used in this network meta-analysis (NMA) to generate the direct and indirect comparison results among multiple treatments in progression-free survival (PFS), overall response rate (ORR), overall survival (OS), complete response (CR), partial response (PR), grade 3 and above adverse events (Grade ≥ 3AE), and any adverse events (Any AE).

Efficient electrocoupling of CO and N to urea by a gas-penetrable Bi nanosheet-wrapped Cu hollow fiber.

A gas-penetrable electrode (GPE) composed of a Bi nanosheet array-wrapped Cu hollow fiber (Bi NSAs@Cu HF) is rationally designed and utilized for efficient electrocoupling of CO and N to produce urea with a yield of 79 μg h cm, a faradaic efficiency (FE) of 6.8%, and excellent cycling stability at -0.2 V reversible hydrogen electrode (RHE).

Performance of radiomics in preoperative determination of malignant potential and Ki-67 expression levels in gastrointestinal stromal tumors: a systematic review and meta-analysis.

Empirical evidence for radiomics predicting the malignant potential and Ki-67 expression in gastrointestinal stromal tumors (GISTs) is lacking. The aim of this review article was to explore the preoperative discriminative performance of radiomics in assessing the malignant potential, mitotic index, and Ki-67 expression levels of GISTs. We systematically searched PubMed, EMBASE, Web of Science, and the Cochrane Library.

The Trend of the Treatment of Advanced Hepatocellular Carcinoma: Combination of Immunotherapy and Targeted Therapy.

Hepatocellular carcinoma (HCC) is a common type of tumor worldwide. The development of systemic treatment of advanced HCC has remained stagnant for a considerable period. During the last years, a series of new treatment regimens based on the combination of immunotherapeutic drugs and targeted drugs have been gradually developed, increased the objective response rate (ORR), overall survival (OS), and progression free survival (PFS) of HCC patients.

Symbiotic defect-reinforced bimetallic MOF-derived fiber components for solar-assisted atmospheric water collection.

Conversion of atmospheric water to sustainable and clean freshwater resources through MOF-based adsorbent has great potential for the renewable environmental industry. However, its daily water production is hampered by susceptibility to agglomeration, slow water evaporation efficiency, and limited water-harvesting capacity. Herein, a solar-assisted bimetallic MOF (BMOF)-derived fiber component that surmounts these limitations and exhibits both optimized water-collect capacity and short adsorption-desorption period is proposed.

A Functionally Asymmetric Janus Hygro-Photothermal Hybrid for Atmospheric Water Harvesting in Arid Regions.

Metal-organic frameworks (MOFs) are high-performance adsorbents for atmospheric water harvesting but have poor water-desorption ability, requiring excess energy input to release the trapped water. Addressing this issue, a Janus-structured adsorbent with functional asymmetry is presented. The material exhibits contrasting functionalities on either face - a hygroscopic face interfaced with a photothermal face.

An exsolved Cu-based electrocatalyst from an intermetallic CuSi compound for efficient CH electrosynthesis.

A Cu-based electrocatalyst (-CuSi) is developed by exsolving ultrathin SiO layer-coated CuO/Cu nanoparticles (<100 nm) on the surface of a conductive intermetallic CuSi parent. This specially designed -CuSi catalyst exhibits high performance for the CO reduction reaction (CORR), which affords an excellent CH faradaic efficiency (FE) of 49.0% with partial current density of over 140.

A hierarchical carbon foam-hosted CoP nanoparticles monolithic electrode for ampere-level and super-durable electrocatalytic hydrogen production.

In this work, we develop a hierarchical carbon foam-based monolithic electrode (CoP@HCF) from Co-adsorbed polyvinyl alcohol (PVA) sponge the successive carbonization and phosphorization. Owing to the 3D hierarchical porous structure, excellent electrolyte wettability, good mechanical strength, and intimate embedding of highly dispersed CoP nanoparticles, the CoP@HCF electrode delivers a high current density of 1.0 A cm for the hydrogen evolution reaction (HER) at ultralow overpotentials of 189.

Water-soluble fullerenol-mediated electron transfer in molecular systems toward enhanced solar hydrogen production.

We present here that visible-light-induced electron transfer from an excited dye to an generated Pt cocatalyst can be promoted by employing water-soluble fullerenol (C(OH)) as an electron mediator, and as a result, the fullerenol-based molecular system shows a 3 times higher H evolution activity than C(OH)-free system.

Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function.

Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract infections (UTIs) in humans. Moreover, as one of the most common bacterial pathogens, UPEC imposes a substantial burden on healthcare systems worldwide. Epithelial cells and macrophages are two major components of the innate immune system, which play critical roles in defending the bladder against UPEC invasion.

A Cu hollow fiber with coaxially grown Bi nanosheet arrays as an integrated gas-penetrable electrode enables high current density and durable formate electrosynthesis.

While high current density formate (HCOO) electrosynthesis from CO reduction has been achieved in a flow cell assembly, the inevitable flooding and salt precipitation of traditional gas-diffusion electrodes (GDEs) severely limit the overall energy efficiency and stability. In this work, an integrated gas-penetrable electrode (GPE) for HCOO electrosynthesis was developed by coaxially growing vertically aligned high density Bi nanosheet arrays on a porous Cu hollow fiber (Bi NSAs@Cu HF) controllable galvanic replacement. The interior porous Cu HF serves as a robust gas-penetrable and conductive host for continuously delivering CO gas to surface-anchored Bi NSAs, resulting in numerous well-balanced triphase active interfaces for the electrocatalytic CO reduction reaction (CORR).

[Dumai moxibustion combined with low-dose tadalafil for erectile dysfunction: Evaluation of therapeutic effect].

Objective: To investigate the clinical effect of dumai (governor meridian) moxibustion combined with low-dose tadalafil in the treatment of ED with decline of vital gate fire.

Methods: We enrolled in this study 130 ED patients with decline of vital gate fire who met the inclusion criteria and equally randomized them into a control and an experimental group, the former treated with low-dose tadalafil tablets at 5 mg once a day while the latter by dumai moxibustion once a week in addition, all for 4 weeks. Of the total number of subjects, 62 in the control group and 63 in the experimental group completed the experiment.

Bimetallic MOF-Derived Solar-Triggered Monolithic Adsorbent for Enhanced Atmospheric Water Harvesting.

The development of economical, energy-saving, and efficient metal-organic framework (MOF)-based adsorbents for atmospheric water collection is highly imperative for the rapid advancement of renewable freshwater resource exploitation. Herein, a feasible one-step solvothermal formation strategy of bimetallic MOF (BMOF) is proposed and applied to construct a solar-triggered monolithic adsorbent for enhanced atmospheric water collection. Benefiting from the reorganization and adjustment of topology structure by Al atoms and Fe atoms, the resultant BMOF(3) consisting of Al-fumarate and MIL-88A has a higher specific surface area (1202.

Lignin as a quasi-homogenous electron mediator enables efficient photocatalytic H evolution in molecular systems.

We report that the biomass-derived lignosulfonate (LS) can function as a quasi-homogenous electron mediator to efficiently promote the electron transfer from the excited erythrosin B (ErB) to the generated Pt cocatalyst under visible light, thus enhancing the photocatalytic H evolution activity by over 10 fold as compared to the LS-free system.

-[MoO]-based multifunctional hybrid material for high catalytic performance on the cycloaddition of CO, esterification and knoevenagel condensation.

Developing materials with excellent properties has become the norm in the field of basic research, prompting us to explore highly robust hybrid materials based on electron-rich POMs and electron-deficient MOFs. Herein, a -[MoO]-based hybrid material of [Cu(BPPP)]{-[MoO]} (NUC-62) with excellent physicochemical stability was self-assembled under acidic solvothermal conditions from NaMoO and CuCl in the presence of a designed chelated ligand of 1,3-bis(3-(2-pyridyl)pyrazol-1-yl)propane (BPPP), which has sufficient coordination sites, spatial self-regulation and great deformation ability. In NUC-62, each of two tetra-coordinated Cu ions and two BPPP are unified into one dinuclear unit serving as the cation, which is interactively linked to -[MoO] anions rich hydrogen bonds of C-H⋯O.

Incorporating paraffin@SiO nanocapsules with abundant surface hydroxyl groups into polydimethylsiloxane to develop composites with enhanced interfacial heat conductance for chip heat dissipation.

Incorporating phase change capsules into polymeric matrices is an effective approach for developing flexible composites with both heat storage capacity and good thermal reliability, while the interfacial heat conductance between the capsules and the matrix has seldom been considered. Herein, paraffin@SiO nanocapsules synthesized by an interfacial polycondensation process using a basic catalyst were incorporated into a polydimethylsiloxane matrix for the first time to prepare phase change composites at different loadings. Furthermore, the composites containing the nanocapsules were systematically compared with the composites containing the paraffin@SiO microcapsules synthesized using an acidic catalyst.

self-exsolved ultrasmall FeP quantum dots from attapulgite nanofibers as superior cocatalysts for solar hydrogen evolution.

Developing highly active, stable, and cost-efficient cocatalysts for photocatalytic H evolution is pivotal in the area of renewable energy conversion. Herein, we present a straightforward, low-temperature phosphidation strategy for exsolving doped Fe ions from natural attapulgite (ATP) nanofibers into a supported FeP cocatalyst for the photocatalytic H evolution reaction (HER). The resulting FeP QDs/ATP features highly dispersed FeP QDs with an average size of <2 nm and a strong interfacial interaction between self-exsolved FeP QDs and the ATP substrate, thus providing ample and stable active sites for the photocatalytic HER.

Boosting CO electroreduction on a Zn electrode concurrent surface reconstruction and interfacial surfactant modification.

Herein, we report an effective strategy for improving the electrocatalytic CO reduction reaction (CORR) performance of a Zn foil electrode concurrent surface reconstruction and interfacial surfactant modification. The oxide-derived and CTAB-modified Zn electrode (OD-Zn-CTAB) prepared by electrochemically reducing the air-annealed Zn foil electrode in the presence of CTAB exhibits high electrocatalytic activity and selectivity for CO production with a CO partial current density () of 8.2 mA cm and a CO faradaic efficiency (FE) of 90% at -1.

Cellular nanomechanics derived from pattern-dependent focal adhesion and cytoskeleton to balance gene transfection of malignant osteosarcoma.

Gene transfection was supposed to be the most promising technology to overcome the vast majority of diseases and it has been popularly reported in clinical applications of gene therapy. In spite of the rapid development of novel transfection materials and methods, the influence of morphology-dependent nanomechanics of malignant osteosarcoma on gene transfection is still unsettled. In this study, cell spreading and adhesion area was adjusted by the prepared micropatterns to regulate focal adhesion (FA) formation and cytoskeletal organization in osteosarcoma cells.

Facilitating charge transfer through an atomic coherent interface of a novel direct Z-scheme BiVO@CuSnS heterojunction to boost photocatalytic performance.

Direct Z-scheme photocatalytic systems are very promising composite photocatalysts, and their photocatalytic performance is highly associated with the quality of the interface within them. Herein, a novel direct Z-scheme heterojunction with a coherent interface has been presented for the first time. Specifically, the heterojunction was constructed by dispersing pre-prepared BiVO crystals into the reaction system to synthesize CuSnS, followed by a hydrothermal reaction.

A Shorter-Bout of HIIT Is More Effective to Promote Serum BDNF and VEGF-A Levels and Improve Cognitive Function in Healthy Young Men.

The aim of this study was to investigate the effects of single bouts of high-intensity interval training (HIIT) with different duration on serum brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor-A (VEGF-A) levels and cognitive function in healthy young men. Twelve healthy young men were participated in two HIIT treatments (20 min HIIT and 30 min HIIT) in a random order. BDNF, VEGF-A, cortisol, testosterone, blood lactic acid were measured and cognitive function was assessed by Stroop test (CWST) and Digital Span test (DST) before, immediately after, and 30 min after HIIT.