Reproductive and transgenerational toxicity of bisphenol S exposure in pregnant rats: Insights into hormonal imbalance and steroid biosynthesis pathway disruption.

Bisphenol S (BPS) is an alternative chemical to bisphenol A commonly used in food packaging materials. It raises concerns due to potential adverse effects on human health. However, limited evidence exists regarding reproductive toxicity from BPS exposure, and the mechanism of associated transgenerational toxicity remains unclear.

Effects of Shengmai Yin on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms: a randomized, double blind, multicenter control trial.

Objective:: To evaluate the efficacy and safety of Shengmai Yin (生脉饮, SMY) on visual analogue scale (VAS) for cardiopulmonary symptoms in coronavirus disease 2019 (COVID-19) convalescent patients.

Methods:: In this randomized, double blind and multicenter controlled trial, a total of 200 COVID-19 convalescent patients who with cardiopulmonary symptoms were enrolled from three medical centers in Hubei, China. These patients were randomized divided into trial group and the control group, 100 patients in each one, SMY and its placebo were applied to respectively, for two weeks.

Benign esophageal schwannoma: A case report and brief overview.

Rationale: Schwannoma is a tumor of the peripheral nervous system that originated in the Schwann cells of the neural sheath. Esophageal schwannomas are rare esophageal submucosal tumors, comprising approximately 2% of esophageal tumors. Since the symptoms, signs, and images of esophageal schwannoma are not specific, its preoperative diagnosis remains challenging.

Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an study.

Titanium (Ti) and its alloys are widely applied as orthopedic implants for hip and knee prostheses, fixation, and dental implants. However, Ti and its alloys are bioinert and susceptible to bacteria and biofilm formation. Thus, surface biofunctionalisation of Ti is essential for improving the biofunction of Ti.

Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis.

Immune systems play pivotal roles in determining the in vivo osseointegration of bone implants. While much evidence has shown that hierarchical implant surfaces can exhibit excellent osteogenic ability, their immune response has not been well elucidated, which will preclude accurate knowledge of their osseointegration performance. In this study, the immunomodulatory properties of a hierarchical macropore/nanosurface as well as the detailed mechanism was investigated.

YAP-mediated mechanotransduction regulates osteogenic and adipogenic differentiation of BMSCs on hierarchical structure.

Hierarchical structure mimicking the natural bone microenvironment has been considered as a promising platform to regulate cell functions. We have previously fabricated hierarchical macropore/nanowire structure and evidence has shown that it can better manipulate the cytoskeleton status and osteogenic performance of osteoblasts. However, how cues of hierarchical structure are translated and ultimately linked to BMSC lineage commitment have still remained elusive, which hinders the accurate knowledge and further development of the hierarchical structure.