PLGA-Nano-Encapsulated Disulfiram Inhibits Cancer Stem Cells and Targets Non-Small Cell Lung Cancer In Vitro and In Vivo.

Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those in typical CSC sphere culture.

Synthesis of a Quaternary Ammonium-Halamine and Preparation on the Modified Nanofibrous Filter with Superior Sterilization, Air Filtration, and Biodegradability.

The outbreak of the 2019 coronavirus pandemic has raised worldwide attention about self-protection from airborne diseases. Air filtration and wearing mask have been proven to be effective measures in reducing the pathogenic aerosol's transmission. Those lead to an increasing demand of high-efficient filters.

Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization.

Malaria remains a global health challenge, disproportionately affecting vulnerable communities. Despite substantial progress, the emergence of anti-malarial drug resistance poses a constant threat. The Greater Mekong Subregion (GMS), which includes Cambodia, China's Yunnan province, Lao People's Democratic Republic, Myanmar, Thailand, and Viet Nam has been the epicentre for the emergence of resistance to successive generations of anti-malarial therapies.

First Report of Bacterial Brown Rot Disease Caused by Ewingella americana on Cultivated Naematelia aurantialba in China.

Naematelia aurantialba (synonym Tremella aurantialba) is one of the jelly fungi and highly valued edible and medicinal mushrooms. It has been cultivated industrially in recent years and consumed popularly in China. In September 2022, brown rot disease of fruiting bodies was observed at the N.

Palladium catalyst immobilized on functionalized microporous organic polymers for C-C coupling reactions.

Two microporous organic polymer immobilized palladium (MOP-Pd) catalysts were prepared from benzene and 1,10-phenanthroline by Scholl coupling reaction and Friedel-Crafts reaction, respectively. The structure and composition of the catalyst were characterized by FT-IR, TGA, N sorption, SEM, TEM, ICP-AES and XPS. MOP-Pd catalysts were found to possess high specific surface areas, large pore volume and low skeletal bone density.

Malaria control along China-Myanmar Border during 2007-2013: an integrated impact evaluation.

Background: Implementing effective interventions remain a lot of difficulties along all border regions. The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matter of great concern. China has effectively controlled cross-border transmission of malaria and artemisinin resistance of P.

Global epidemiology of yaws: a systematic review.

Background: To achieve yaws eradication, the use of the new WHO strategy of initial mass treatment with azithromycin and surveillance twice a year needs to be extended everywhere the disease occurs. However, the geographic scope of the disease is unknown. We aimed to synthesise published and unpublished work to update the reported number of people with yaws at national and subnational levels and to estimate at-risk populations.

A multicenter study on etiology of acute pancreatitis in Beijing during 5 years.

Objectives: The aim of this study was to determine the etiology tendency of acute pancreatitis (AP) in the Beijing region and the relationship with influencing factors.

Methods: This retrospective multicenter study enrolled 8 representative general hospitals from January 1, 2006 to December 31, 2010. The etiology tendency was analyzed, and the relationship was defined with sex, aging, severity, mortality, recrudesce rate, length of stay, and hospitalization cost.

Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey.

Yaws, a non-venereal treponemal disease, is targeted for eradication by 2020 but accurate epidemiological data to guide control programs remain sparse. The Solomon Islands reports the second highest number of cases of yaws worldwide. We conducted a cluster randomized survey of yaws in two provinces of the Solomon Islands.

Evaluation of a rapid diagnostic test for yaws infection in a community surveillance setting.

Yaws is a non-venereal treponemal infection caused by Treponema pallidum ssp. pertenue. The WHO has launched a worldwide control programme, which aims to eradicate yaws by 2020.

Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database.

Objective: This study was aimed to create a large-scale laryngeal cancer relevant secretory/releasing protein database and further discover candidate biomarkers.

Methods: Primary tissue cultures were established using tumor tissues and matched normal mucosal tissues collected from four laryngeal cancer patients. Serum-free conditioned medium (CM) samples were collected.

Lymphatic filariasis in Papua New Guinea: distribution at district level and impact of mass drug administration, 1980 to 2011.

Background: Lymphatic filariasis (LF) caused by Wuchereria bancrofti is present at high prevalence in some parts of Papua New Guinea. However, there has been no rigorous data-based representative assessment of nationwide prevalence of LF. The LF programme has been daunted by the scope of the problem, and progress on mass drug administration (MDA) has been slow and lacking in resources.

[Therapeutic efficacy and safety of compound dihydroartemisinin/piperaquine for uncomplicated Plasmodium falciparum infection in Laiza City of Myanmar bordering on China].

Objective: To assess the efficacy and safety of compound dihydroartemisinin/piperaquine (DHAPIP) for treating uncomplicated falciparum malaria in Laiza city of Myanmar at the China-Myanmar border area.

Methods: A clinical trial was conducted in Laiza City and its four suburban natural villages bordering with China from September to December in 2008. Patients (aged 2-60 years) infected by Plasmodium falciparum without clinical complications (> or = 250 asexual parasite x microl(-1) of whole blood) were recruited for the assessment.

[Surgical treatment and prognosis analysis on medullary thyroid carcinoma].

Objective: To study the clinical characteristics, the surgical treatments and the prognostic factors of medullary thyroid carcinoma.

Methods: Eighty-two cases of medullary thyroid carcinoma undergoing surgeries between January 1999 and December 2004 were reviewed. There were 39 males and 43 females.

Multidrug-resistant genotypes of Plasmodium falciparum, Myanmar.

We performed a molecular epidemiologic survey of mutations associated with drug-resistance genes in Plasmodium falciparum in northeastern Myanmar. In this region, 3 highly mutated drug-resistance haplotypes and 1 associated with decreased quinine susceptibility were prevalent, which suggests that parasites may be resistant to multiple commonly used antimalarial drugs.

[Genotyping of Plasmodium vivax in China-myanmar border by circumsporozoite protein].

By using a series of type-specific primers for Plasmodium vivax circumsporozoite protein (CSP) gene and nested PCR, genotyping was conducted for the specimens of Plasmodium vivax isolated from China-Myanmar border. In 174 isolates of P. vivax, four genotypes, namely, tropical zone family strain, temperate zone family strain, genotype-mixed infection and PV-II type, were identified each accounting for 54.

[Clinical analysis of 60 cases with maxillary squamous cell carcinoma].

Objective: To study the clinical characters, treatment modalities and prognosis of patients with maxillary squamous cell carcinoma.

Methods: The clinical data of 60 patients with maxillary squamous cell carcinoma treatment between January 1994 and December 2004 were analyzed retrospectively. The patients were treated with three therapy modalities including radiotherapy alone (22 cases), radiotherapy and surgery (R + S, 29 cases) and concurrent chemo-radio-therapy adjuvant surgery (CCR + S, 9 cases).

Co-infections with Plasmodium knowlesi and other malaria parasites, Myanmar.

To determine the frequency of co-infections with Plasmodium species in southern Myanmar, we investigated the prevalence of P. knowlesi. More than 20% of patients with malaria had P.

Plasma concentration of malaria parasite-derived macrophage migration inhibitory factor in uncomplicated malaria patients correlates with parasitemia and disease severity.

Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response. However, the role of Plasmodium MIFs in the immunopathogenesis of malaria infection and the relationships between these mediators and inflammatory cytokines remained unclear.

Protective effects of Salvia miltiorrhiza against cisplatin-induced ototoxicity in guinea pigs.

Objective: The aim of the study was to investigate the protective effects of Salvia miltiorrhiza (SM) against cisplatin-induced ototoxicity in guinea pigs.

Methods: Thirty-nine guinea pigs were randomly divided into 3 groups. The first group (control group) received physiologic saline by intraperitoneal (i.

[Serological detection of malaria for people entering China from 19 ports of entry covering 8 border prefectures of Yunnan].

Objective: To evaluate malaria situation in areas of Yunnan Province bordering with Myanmar, Laos and Vietnam.

Methods: Blood samples on filter paper were collected from the entry people in March to December of 2007 involving 19 national and provincial ports of entry. Indirect fluorescent antibody test (IFAT) was carried out by using the blood samples collected before June 30 as the first half year and after July 1 as the second half year.

[Sensitivity of Plasmodium vivax to chloroquine in Laza City, Myanmar].

Fourty-eight patients infected by Plasmodium vivax were randomly divided into chloroquine regimen groups A and B. Each case in group A received a total dosage of 1 200 mg(base) over a 3-day period (600 mg on the first day then 300 mg daily). Cases in group B each received total dosage of 1 500 mg (base) in 3 days (750 mg on the first day then 375 mg daily).