Publications by authors named "Zhang Yuqing"

Developing a DNA autocatalysis-oriented cascade circuit (AOCC) via reciprocal navigation of two enzyme-free hug-amplifiers might be desirable for constructing a rapid, efficient, and sensitive assay-to-treat platform. In response to a specific trigger (), seven functional DNA hairpins were designed to execute three-branched assembly (TBA) and three isotropic hybridization chain reaction (3HCR) events for operating the AOCC. This was because three new inducers were reconstructed in TBA arms to initiate 3HCR (TBA-to-3HCR) and periodic repeats were resultantly reassembled in the tandem nicks of polymeric nanowires to rapidly activate TBA in the opposite direction (3HCR-to-TBA) without steric hindrance, thereby cooperatively manipulating sustainable AOCC progress for exponential hug-amplification (1:3).

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Importance: Limb spasticity is a common issue among stroke patients. Transcutaneous electrical acupoint stimulation (TEAS) is recommended as an alternative therapy for managing upper limb spasticity after stroke; however, its potential effects and feasibility remain uncertain.

Objective: To investigate the potential effects and feasibility of TEAS on motor function in patients with upper limb spasticity after stroke.

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Hantaan virus (HTNV) infection causes severe hemorrhagic fever with renal syndrome (HFRS) in humans and the infectious process can be regulated by autophagy. The phosphatase and tensin homolog (PTEN) protein has antiviral effects and plays a critical role in the autophagy pathway. However, the relationship between PTEN and HTNV infection is not clear and whether PTEN-regulated autophagy involves in HTNV replication is unknown.

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The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills (CDDP) in improving cardiac function among patients with acute anterior ST-segment elevation myocardial infarction (AAMI). Between February 2021 and February 2023, 247 eligible patients with AAMI after primary percutaneous coronary intervention (pPCI) were enrolled and randomly assigned (1∶1) to receive CDDP ( = 126) or placebo ( = 121), with a follow-up of 48 weeks. Compared with the placebo group, the CDDP group demonstrated a significant increase in left ventricular ejection fraction (LVEF) values after 24 weeks of the treatment (least squares mean: 3.

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The objective of this study is to gain insight into the current research frontiers, hotspots, and development trends in the field of immunization programs for women and children, and to provide scientific guidance and reference for follow-up research. Based on all the original research papers related to the research on immunization programs for women and children in the Web of Science Core Collection (WoSCC) database, bibliometric studies and visual analysis were carried out to explore the research frontiers, hotspots and development trends, and to analyze the risk factors affecting the vaccination coverage of immunization programs for women and children. Eight hundred forty-three papers obtained from 1,552 institutions in 96 countries/regions from January 1950 to August 2024, coauthored by 4,343 authors.

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High-performance bulk graphite (HPBG) that simultaneously integrates superior electrical conductivity and excellent strength is in high demand, yet it remains critical and challenging. Herein a novel approach is introduced utilizing MOF-derived nanoporous metal/carbon composites as precursors to circumvent this traditional trade-off. The resulting bulk graphite, composed of densely packed multilayered graphene sheets functionalized with diverse cobalt forms (nanoparticles, single atoms, and clusters), exhibits unprecedented electrical conductivity in all directions (in-plane: 7311 S cm⁻¹, out-of-plane: 5541 S cm⁻¹) and excellent mechanical strength (flexural: 101.

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Background: Current research has focused on exploring the sources of parents' anxiety about children's education (PAE), and we continue in this direction by exploring the factors influencing parental educational anxiety in primary and secondary school students and the interactions among them.

Methods: Parental Educational Anxiety Measurement Questionnaire was used to measure the level of PEA. Pearson correlation coefficient analysis was used to examine the correlation between the level of PAE and the demographic variables.

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Triple-negative breast cancer (TNBC) is highly prone to early relapse and metastasis following standard treatment. CXCL8 is a key factor in tumor invasion and metastasis, but its role in TNBC prognosis and clinicopathological correlations remains poorly understood. This study investigated CXCL8 expression and its clinical significance in TNBC to develop a prognostic nomogram for guiding intensive treatment and follow-up strategies.

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Background: Low-intensity pulsed ultrasound (LIPUS) has been used as an effective noninvasive method for treating fractures and osteoarthrosis, but the application in the field of oral implantation is in its infancy. This study aimed to clarify the effect and mechanism of LIPUS on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and implant osseointegration, and to provide an experimental basis for future clinical applications.

Methods: Dental implants were inserted into Wistar rat femurs, and LIPUS was performed for 4 weeks.

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Purpose: To present an innovative deformable applicator that used Freiburg flap as vaginal applicator with or without free-hand interstitial needles in three-dimensional (3D) high-dose-rate (HDR) brachytherapy for vaginal stump recurrence of cervical cancer.

Material And Methods: Between September 2017 and January 2020, all patients with vaginal stump recurrence after radical hysterectomy of cervical cancer treated with vaginal stump brachytherapy using Freiburg flap as vaginal applicator with or without free-hand interstitial needles were retrospective analyzed. Characteristics related to patients and treatment modality as well as preliminary outcomes and side effects were investigated.

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With no standard method to capture penicillin allergy de-labeling prevalence across populations, we developed and validated a simple penicillin allergy de-labeling prevalence measure from electronic health records that achieved perfect sensitivity (100.0%), high specificity (99.4%), and strong agreement with a comprehensive algorithm that included free-text manual review (Kappa=0.

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Objective: To use routine demographic and clinical data to develop an interpretable individual-level machine learning (ML) model to diagnose knee osteoarthritis (KOA) and to identify highly ranked features.

Methods: In this retrospective, population-based cohort study, anonymized questionnaire data was retrieved from the Wu Chuan KOA Study, Inner Mongolia, China. After feature selections, participants were divided in a 7:3 ratio into training and test sets.

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Commercial DHA-rich algal oil has some issues, such as an unpleasant odor and susceptibility to oxidation. The main fishy odor compounds in commercial DHA-rich algal oil powder and DHA-rich algal oil microcapsules are hexanal and (E, E)-2,4-heptadienal. To address this issue, a microencapsulation process was designed for DHA-rich algal oil using infant rice powder (IRP), maltodextrin (MD), and whey protein concentrate (WPC) as wall materials, with sodium starch octenyl succinate (SSOS) and monoacylglycerol (MAC) as emulsifiers.

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Prediabetes is a serious metabolic disorder that is often overlooked and 70% of individuals with prediabetes would eventually develop type 2 diabetes. The diabetogenic effects of pesticides have been reported in toxicological studies but their association with prediabetes is rarely investigated. We aimed to evaluate the association between pesticide exposure and impaired glucose regulation (IGR), including prediabetes (defined as impaired fasting glucose [IFG] and/or impaired glucose tolerance [IGT]) and insulin resistance, in a general U.

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The proper encapsulation of liposoluble tea polyphenols (LTP) is expected to better protect oil system. Chitosan hydrochloride-carboxymethyl starch (CHC-CMS) nanoparticles-based Pickering emulsions and hydroxypropyl methylcellulose/sodium citrate (HPMC/SC) microporous film were combined to embed and control-release LTP. With the CHC:CMS ratio varied from 1:0.

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Article Synopsis
  • The study introduces CoNSA-POase, an artificial peroxygenase made from single-atom cobalt supported on polymeric carbon nitrogen, which shows excellent performance in converting aromatic alkanes to ketones.
  • Density functional theory indicates that this artificial enzyme operates via a different catalytic mechanism compared to natural peroxygenases.
  • The integration of CoNSA-POase with other enzymes in continuous-flow systems enhances the efficient production of chiral alcohols and amines, suggesting potential advancements in enzyme-based applications.
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Groundwater is a critical resource for economic growth and livelihoods in the dense agricultural plains of plateaus. However, contaminations from various sources pose significant threats to groundwater quality. Understanding the sources of groundwater contamination and the mechanisms of hydrochemical control is essential for the sustainable development of agriculturally intensive plains.

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Behavioral and psychological symptoms of dementia (BPSD) are common and difficult to manage. Although experimental data suggest that antidepressants may reduce BPSD, the results are inconclusive. To evaluate the efficacy and tolerability of antidepressants monotherapy for treating BPSD.

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Background: The results of Study 1 we have published proved that medium and high doses of Gegen Qinlian Decoction (GQD) were effective in treating type 2 diabetes (T2D) with damp-heat syndrome. However, whether the main drug of GQD in treating T2D was or has always been a hot topic of debate among many doctors. Therefore, we conducted Study 2 and Study 3 to determine the main drug of GQD for treating T2D.

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CYP3A, a key member of the cytochrome P450 (CYP450) superfamily, is integral to drug metabolism, processing a substantial portion of medications. Their role in drug metabolism is particularly prominent, as CYP3A4 and CYP3A5 metabolize approximately 30-50% of known drugs. The genetic polymorphism of CYP3A4/5 is significant inter-individual variability in enzymatic activity, which can result in different pharmacokinetic profiles in response to the same drug among individuals.

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Background: Human interleukin-33 (IL-33), a member of the IL-1 family, has been identified as a therapeutic target due to its role as a proinflammatory mediator in various diseases. This study aims to evaluate the prognostic value of serum IL-33 levels in patients admitted with their first-ever acute ischemic stroke.

Methods: This single-center, prospective, observational study included 216 patients with acute ischemic stroke.

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Fabry disease (FD) is a rare X-linked inherited lysosomal storage disorder. The abnormal accumulation of metabolic substrates induces inflammation and fibrosis in cells, resulting in organ dysfunction. The clinical manifestations of FD are diverse and non-specific.

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Article Synopsis
  • * A new green recovery strategy is proposed using natural low-melting mixture solvents (LoMMSs) that are safe, cost-effective, biodegradable, and highly efficient for extracting metals from ASIBs.
  • * This method achieves nearly 100% extraction of sodium with high selectivity and allows for cost-effective metal precipitation using water, making it more energy-efficient than traditional lithium-ion battery recycling.
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Importance: Clinicians often approach urate-lowering therapy (ULT) cautiously in patients with gout and impaired kidney function because they are concerned about the risk of progression to severe or end-stage kidney disease. However, evidence from randomized clinical trials of this association remains inconclusive.

Objective: To evaluate the association between achieving target serum urate level with ULT and progression of chronic kidney disease (CKD) to severe or end-stage in patients with gout and impaired kidney function.

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Background: Excessive iron accumulation in the brain has been implicated in Parkinson's disease (PD). However, the patterns and probable sequences of iron accumulation across the PD brain remain largely unknown. This study aimed to explore the sequence of iron accumulation across the PD brain using R* mapping and a relaxometry covariance network (RCN) approach.

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