Intraoperative tranexamic acid reduces postoperative haemarthrosis and improves early functional outcomes in double-bundle anterior cruciate ligament reconstruction.

Introduction: Double-bundle anterior cruciate ligament reconstruction (ACLR) has biomechanical advantages but is associated with increased intraoperative bleeding. The role of tranexamic acid (TXA) in reducing postoperative joint haemarthrosis and improving the short-term outcomes of double-bundle ACLR has not yet been thoroughly investigated. This study aimed to assess the effects of intraoperative TXA on postoperative joint haemarthrosis and short-term functional outcomes in patients who underwent double-bundle ACLR.

Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases.

Organoid is an ideal in vitro model with cellular heterogeneity and genetic stability when passaging. Currently, organoids are exploited as new tools in a variety of preclinical researches and applications for disease modeling, drug screening, host-microbial interactions, and regenerative therapy. Advances have been made in the establishment of nasal and olfactory epithelium organoids that are used to investigate the pathogenesis of smell-related diseases and cellular/molecular mechanism underlying the regeneration of olfactory epithelium.

Combined Physiological and Transcriptomic Analysis Reveals Key Regulatory Networks and Potential Hub Genes Controlling Chilling Tolerance During Soybean Germination.

Chilling is an important limiting factor for seed germination of soybean ( [L.] Merr.).

Short-term outcomes of AVN CAGE implantation for early-stage osteonecrosis of the femoral head.

Purpose: Considering the low survival rate for the numerous hip-preserving procedures developed for treating early-stage osteonecrosis of the femoral head (ONFH), this study aimed to evaluate short-term clinical outcomes following avascular necrosis (AVN) CAGE implantation.

Methods: 58 hips with early-stage ONFH (44 with Association Research Circulation Osseous [ARCO] stage 2 and 14 with stage 3A) treated with the AVN CAGE between August 2018 and December 2021 were included. The survival rates were analysed using radiographic progression and conversion to subsequent total hip arthroplasty (THA) as endpoints.

Decoding AI ethics from Users' lens in education: A systematic review.

In recent years, Artificial Intelligence (AI) has witnessed remarkable expansion, greatly benefiting the education sector. Nonetheless, this advancement brings forth several ethical dilemmas. The existing research on these ethical concerns within the educational framework is notably scarce, particularly when viewed from a user's standpoint.

Comprehensive Analysis of Mitotane-Related Adverse Events Using the Food and Drug Administration Adverse Event Reporting System.

Objective: Mitotane is currently the only product approved by the Food and Drug Administration for the treatment of adrenocortical cancer. However, there is a lack of comprehensive studies on the adverse events of mitotane.

Methods: Adverse event reports for mitotane in the Food and Drug Administration Adverse Event Reporting System database since 2004 were collected and analyzed to identify mitotane as the primary suspect drug.

Hydrochemical assessment of groundwater utilizing statistical analysis, integrated geochemical methods, and EWQI: a case study of Laiwu region, North China.

The investigation of groundwater quality and hydrochemical assessment holds immense significance in safeguarding and ensuring the rational utilization of groundwater resources. This study utilizes groundwater sampling and testing data from the Laiwu region (LWR), encompassing both dry and wet seasons, to delve into the hydrochemical characteristics, ion sources, and overall groundwater quality. The research findings indicate that the groundwater in LWR exhibits weak alkalinity, with the dominant ions being Ca followed by Mg, Na, and K, and HCO, SO, NO, Cl, and F.

Rapid on-site detection of illicit drugs in urine using C18 pipette-tip based solid-phase extraction coupled with a miniaturized mass spectrometer.

Drug abuse is a social issue worldwide, and there is an increasing demand for on-site rapid detection of illicit drugs. In this study, a rapid and simple analytical method for the detection of 6-monoacetylmorphine (6-MAM), methamphetamine (MA), methylenedioxymethamphetamine (MDMA), ketamine (K), norketamine (NK), and cocaine (COC) in urine was developed. The developed method combines C18 pipette-tip based solid-phase extraction (C18 PT-SPE) with a miniaturized mass spectrometer (miniMS), exhibiting remarkable simplicity, high sensitivity, and strong reliability, compared with the conventional method.

Biocompatible Hydrogel Coating on Silicone Rubber with Improved Antifouling and Durable Lubricious Properties.

Silicone rubber is widely used in various medical applications. However, silicone rubber is prone to biofouling due to their affinity for lipids and has a high friction coefficient, which can significantly impact their efficacy and performance used as medical devices. Thus, the development of hydrogels with antifouling and lubricious abilities for the modification of silicone rubber is in high demand.

Mitigating the effects of polyethylene microplastics on Pisum sativum L. quality by applying microplastics-degrading bacteria: A field study.

Polyethylene microplastics (PE-MPs) have been widely reported for their adverse effects on soil ecosystems. However, there are fewer field studies on addressing PE-MPs contamination in soil. This study investigated the effects of PE-MPs on soil properties, rhizosphere soil microorganisms, and pea (Pisum sativum L.

A new angiographic scoring for grading the difficulty of recanalization for symptomatic non-acute middle cerebral artery occlusions.

Background: Endovascular recanalization is a feasible option for treating symptomatic non-acute middle cerebral artery occlusion (MCAO) patients. Hence, we aimed to establish a new angiographic scoring to grade the recanalization difficulty of MCAO to determine the suitable patients for endovascular treatment.

Methods: We retrospectively analyzed a total of 113 consecutive recurrent symptomatic non-acute MCAO patients who underwent endovascular recanalization from July 2015 to August 2021 in four Chinese comprehensive stroke centers.

MFLUnet: multi-scale fusion lightweight Unet for medical image segmentation.

Recently, the use of point-of-care medical devices has been increasing; however, many Unet and its latest variant networks have numerous parameters, high computational complexity, and slow inference speed, making them unsuitable for deployment on these point-of-care or mobile devices. In order to deploy in the real medical environment, we propose a multi-scale fusion lightweight network (MFLUnet), a CNN-based lightweight medical image segmentation model. For the information extraction ability and utilization efficiency of the network, we propose two modules, MSBDCB and EF module, which enable the model to effectively extract local features and global features and integrate multi-scale and multi-stage information while maintaining low computational complexity.

Neural substrates for regulating self-grooming behavior in rodents.

Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions including, but not limited to, hygiene maintenance, thermoregulation, de-arousal, stress reduction, and social behaviors. In rodents, grooming involves a patterned and sequenced structure, known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style, beginning from the nose to the face, to the head, and finally ending with body licking. The context-dependent occurrence of grooming behavior indicates its adaptive significance.

Integrated Design of Homogeneous/Heterogeneous Copper Complex Catalysts to Enable Synergistic Effects on Sulfur and Lithium Evolution Reactions.

Fatal polysulfide shuttling, sluggish sulfur redox kinetics and detrimental lithium dendrites have curtailed the real discharge capacity, working lifespan and safety of lithium-sulfur (Li-S) batteries. Organic small molecule promotors as one type of emerging active catalysts can fulfil the management of the electrochemical species evolution behaviors. Herein, an integrated engineering is organized by synthesizing dual chlorine-bridge enabled binuclear copper complex (Cu(phen)Cl) and its derivative generated in electrolyte (Cu-ETL) as the heterogeneous and homogeneous catalyst, respectively.

Degradation and preservation of nitrites in whole blood.

Understanding the factors that influence nitrite degradation in whole blood and developing methods for its stable preservation are crucial for ensuring accurate and reliable forensic identification in cases of nitrite poisoning. This study systematically monitored nitrite degradation and changes in hemoglobin proportions across different initial nitrite concentrations and blood samples. It was revealed that high nitrite concentrations rapidly reduced deoxyhemoglobin levels within the first 15 minutes and subsequently reacted with oxyhemoglobin at a slower rate.

Pre-carbonized nickel-metal organic frameworks to enable lithium-sulfur reactions.

Metal-organic frameworks, a type of porous architecture, have caught wide attention for their pore-rich and special metal-active centres. However, the non-conductive MOFs show limitations in lithium-sulfur batteries (LSBs). Herein, we first synthesized a lamellar nickel-based MOF and subsequently conducted pre-carbonization to attain a conductive Ni-carbon (Ni@C) catalyst.

Proangiogenic potential of plasma exosomes from prostate cancer patients.

Angiogenesis plays a pivotal role in the progression and metastasis of solid cancers, including prostate cancer (PCa). While small extracellular vesicles derived from PCa cell lines induce a proangiogenic phenotype in vascular endothelial cells, the contribution of plasma exosomes from patients with PCa to this process remains unclear. Here, we successfully extracted and characterized plasma exosomes.