Regioselective Deacetylation of Peracetylated Deoxy--glycopyranosides by Boron Trichloride (BCl).

A general approach for regioselective deacetylation at sugar 3-OH of peracetylated 6-deoxy--glucopyranosides mediated by BCl was developed. The approach could be extended to other sugar-derived 6-deoxy--glycopyranosides, such as those derived from mannose, galactose, and rhamnose, with deacetylation occurring at varied sugar hydroxyl groups, and further extended to 4-deoxy--glucopyranosides with deacetylation occurring at sugar 3-OH. The approach would enable access to synthetically challenging carbohydrate derivatives.

A Probability Fusion Approach for Foot Placement Prediction in Complex Terrains.

Prediction of foot placement presents great potential in better assisting the walking of people with lower-limb disability in daily terrains. Previous researches mainly focus on foot placement prediction in level ground walking, however these methods cannot be applied to daily complex terrains including ramps, stairs, and level ground with obstacles. To predict foot placement in complex terrains, this paper presents a probability fusion approach for foot placement prediction in complex terrains which consists of two parts: model training and foot placement prediction.

Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets.

Context: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With the rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results to fight COVID-19 with different mechanisms of action.

Effectiveness and safety of Xuefu Zhuyu oral liquid on -stagnation and blood-stasis pattern in patients with stable angina, tension-type headache and primary dysmenorrhea: rationale and design of a master protocol.

We present the rationale and design of a master protocol study that clarifies the effectiveness and safety of Chinese herbal formulas on -stagnation and blood-stasis pattern (QBP). Three randomized controlled trials (RCTs) and real-world observational studies. Based on three registry cohorts of stable angina, tension-type headache and primary dysmenorrhea, patients with QBP will be enrolled in RCTs to receive either Xuefu Zhuyu (, XFZY) oral liquid or a placebo, while patients with non-QBP will be enrolled in the observational studies and experience follow-up.

[Research progress of botulinum toxin type A in the treatment of chronic rhinitis].

Botulinum toxin（BoNT）, a superfamily of neurotoxins produced by the bacterium Clostridium botulinum, disturbs the signal transmission at the neuromuscular and neuroglandular junctions by inhibiting the neurotransmitter release from the presynaptic nerve terminal. BoNT has been widely used in neuromuscular, hypersecretory, and autonomic nerve system disorders. In recent years, botulinum toxin type A（BoNT-A） has been used to treat chronic rhinitis.

A Bibliometric Analysis of the Hotspots Concerning Stem Cell Extracellular Vesicles for Diabetes in the Last 5 Years.

Background: Diabetes mellitus (DM) is a metabolic disease that endangers human health, and its prevalence is exploding and younger. Stem cell-derived extracellular vesicles (SC-EVs) have a repair function similar to SCs and no risk of tumor formation, which have been widely used in the repair of DM and its complications. We aim to map the hot trends of SC-EVs for the treatment of DM and providing directions for future research.

Strongly interfacial-coupled 2D-2D TiO/g-CN heterostructure for enhanced visible-light induced synthesis and conversion.

Two-dimensional (2D) nanosheet-based nanocomposites have attracted intensive interest owing to the unique electronic and optical properties from their constituent phases and the synergistic effect from the heterojunctions. In this study, an interfacial coupled TiO/g-CN 2D-2D heterostructure has been prepared via in situ growth of ultrathin 2D-TiO on dispersed g-CN nanosheets. This strongly coupled 2D-2D TiO/g-CN, different from the weakly bonded 2D-TiO/g-CN heterostructures produced by mechanical mixing, has unique electronic structures and chemical states due to strong interlayer charge transfer, confirmed by both experimental and theoretical analyses.

Bioinspired 2D Nanomaterials for Sustainable Applications.

The increasing demand for constructing ecological civilization and promoting socially sustainable development has encouraged scientists to develop bioinspired materials with required properties and functions. By bringing science and nature together, plenty of novel materials with extraordinary properties can be created by learning the best from natural species. In combination with the exceptional features of 2D nanomaterials, bioinspired 2D nanomaterials and technologies have delivered significant achievements.