Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression.

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignancy affecting the liver and biliary system. Enhanced understanding of the pathogenic mechanisms underlying iCCA tumorigenesis and the discovery of appropriate therapeutic targets are imperative to improve patient outcomes. Here, we investigated the functions and regulations of solute carrier family 16 member 3 (SLC16A3), which has been reported to be a biomarker of poor prognosis in iCCA.

Genetic association between human skin microbiota with vaginitis: a two-sample Mendelian randomization study.

The human skin microbiome is closely associated with various diseases. We aimed to find the causal association of the human skin microbiome with vaginitis. A two-way two-sample Mendelian randomization study used summary statistics of the human skin microbiota from the largest genome-wide association study meta-analysis.

PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism.

While metabolic reprogramming and remodeling of tumor microenvironment play important roles in the development of esophageal squamous cell carcinoma (ESCC), the mechanisms remain unclear. In this study, we found that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in ESCC and its expression level is associated with lymph node metastasis. PPDPF was found to promote tumorigenesis, lymph node metastasis and distal metastasis of ESCC cells.

Research advance in the effects of litter input on forest soil organic carbon transformation and stability.

The turnover and stabilization of soil organic carbon are tightly associated with the properties of litter input. Due to the complexity of litter decomposition and the high heterogeneity of forest soils, there are considerable uncertainties about how soil minerals, microorganisms, and environmental factors jointly regulate the transformation and stability of litter-derived soil organic carbon. Here, we present an overview of the "microbial efficiency-matrix stabilization" framework centered on microbial metabolism and organic carbon transformation, as well as the new "microbial carbon pump" and "mineral carbon pump" theories in forest soil organic carbon transformation and stabilization.

Effects of and mixture on morphological characteristics of ectomycorrhizae.

The mycorrhizal diversity and morphological plasticity determine the adaptability of host plants to habitat changes. To understand the effects of mixture between coniferous and broadleaf trees on the morphological characteri-stics of ectomyzorrhizal (EcM) associations, we examined the influences of environmental factors on changes in morphological characteristics based on a systematic investigation of the EcM morphological traits in Carr. and Koidz.

Differential responses of soil phosphorus fractions to varied nitrogen compound additions in a meadow steppe.

Nitrogen (N) addition can greatly influence soil inorganic phosphorus (Pi) and organic phosphorus (Po) transformations. However, whether and how the N compound forms may differentially affect the soil P fractions remain unclear. Here, we investigated the responses of soil Pi (labile Pi, moderately-occluded Pi, and recalcitrant Pi) and Po fractions (labile Po and stable Po) to varying addition rates of three N compounds ((NH)SO, NHNO, and urea) in a meadow steppe in northern China.

Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression.

Loss of phosphatase and tensin homolog (PTEN) has been linked to an immunosuppressive tumor microenvironment, but its underlying mechanisms remain largely enigmatic. Here, we report that PTEN can be secreted by the transmembrane emp24 domain-containing protein 10 (TMED10)-channeled protein secretion pathway. Inhibiting PTEN secretion from tumor cells contributes to immunosuppression and impairs the tumor-suppressive role of PTEN, while intratumoral injection of PTEN protein promotes antitumor immunity and suppresses tumor growth in mice.

Assessing the formation and stability of paddy soil aggregate driven by organic carbon and Fe/Al oxides in rice straw cyclic utilization strategies: Insight from a six-year field trial.

Soil organic carbon (SOC) and iron/aluminum (Fe/Al) oxides are key cementing agents in driving soil aggregate formation, yet their direct effects and interactions on aggregate under long-term rice straw cyclic utilization (LSCU) in cold regions are still unclear. We compared chemical fertilizer (CF) with LSCU strategy: rice-straw (RS), biochar (RB), and biochar-based fertilizer (BF). We showed that the increase of macroaggregate (2-0.

Microbial Sulfur and Arsenic Oxidation Facilitate the Establishment of Biocrusts during Reclamation of Degraded Mine Tailings.

Degraded tailings generated by the mining of metal ores are major environmental threats to the surrounding ecosystems. Tailing reclamation, however, is often impeded due to adverse environmental conditions, with depleted key nutrients (i.e.

Global pattern of organic carbon pools in forest soils.

Understanding the mechanisms of soil organic carbon (SOC) sequestration in forests is vital to ecosystem carbon budgeting and helps gain insight in the functioning and sustainable management of world forests. An explicit knowledge of the mechanisms driving global SOC sequestration in forests is still lacking because of the complex interplays between climate, soil, and forest type in influencing SOC pool size and stability. Based on a synthesis of 1179 observations from 292 studies across global forests, we quantified the relative importance of climate, soil property, and forest type on total SOC content and the specific contents of physical (particulate vs.

Salvianolic acid B enhances tissue repair and regeneration by regulating immune cell migration and Caveolin-1-mediated blastema formation in zebrafish.

Introduction: Non-healing wounds resulting from trauma, surgery, and chronic diseases annually affect millions of individuals globally, with limited therapeutic strategies available due to the incomplete understanding of the molecular processes governing tissue repair and regeneration. Salvianolic acid B (Sal B) has shown promising bioactivities in promoting angiogenesis and inhibiting inflammation. However, its regulatory mechanisms in tissue regeneration remain unclear.

Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator.

Bacterial infections, as the second leading cause of global death, are commonly treated with antibiotics. However, the improper use of antibiotics contributes to the development of bacterial resistance. Therefore, the accurate differentiation between bacterial and non-bacterial inflammations is of utmost importance in the judicious administration of clinical antibiotics and the prevention of bacterial resistance.

Long term co-application of biochar and fertilizer could increase soybean yield under continuous cropping: insights from photosynthetic physiology.

Background: Photosynthesis is the key to crop yield. The effect of biochar on photosynthetic physiology and soybean yield under continuous cropping is unclear. We conducted a long-term field experiment to investigate the effects of co-application of biochar and fertilizer (BCAF) on these parameters.

Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration.

Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic injury, which has the potential to advance towards cirrhosis and hepatocellular carcinoma. Dietary naringin consumption contributes to protection against LF in animal studies, while the exact protective mechanism of naringin remains unclear. This study aimed to investigate the molecular mechanisms behind the potential protective effect of naringin against TAA-induced LF in zebrafish.

Exposure to irregular microplastic shed from baby bottles activates the ROS/NLRP3/Caspase-1 signaling pathway, causing intestinal inflammation.

Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study presents an initial analysis of the thermal-oxidative aging process of plastic shedding from feeding bottles, and investigates the inflammatory response induced by these atypical MPs in human intestinal cells (Caco-2). The PP-IFBs' surface displayed non-uniform white patches and increased roughness, revealing substantial structural alteration and shedding, especially during actions such as shaking, boiling water disinfection, and microwave heating.

Effects of oyster shells on maturity and calcium activation in organic solid waste compost.

With the rapid development of aquaculture, the production of oyster shells has surged, posing a potential threat to the environment. While oyster shell powder is widely recognized for its inherent alkalinity and rich calcium carbonate content, making it a superior soil conditioner, its role in organic solid waste composting remains underexplored. To investigate the effects of varying concentrations of oyster shell powder on compost maturation and calcium activation, this study employed thermophilic co-composting with acidic sugar residue and bean pulp, incorporating 0% (control), 10% (T1), 20% (T2), 30% (T3), and 40% (T4) oyster shell powder.

Erchen decoction alleviates the progression of NAFLD by inhibiting lipid accumulation and iron overload through Caveolin-1 signaling.

Ethnopharmacological Relevance: A combination of 6 different Chinese herbs known as Erchen decoction (ECD) has been traditionally used to treat digestive tract diseases and found to have a protective effect against nonalcoholic fatty liver disease (NAFLD). Despite its efficacy in treating NAFLD, the precise molecular mechanism by which Erchen Decoction regulated iron ion metabolism to prevent disease progression remained poorly understood.

Aim Of Study: Our study attempted to confirm the specific mechanism of ECD in reducing lipid and iron in NAFLD from the perspective of regulating the expression of Caveolin-1 (Cav-1).

Could continuous rice cropping increase soil fertility and rice productivity by rice straw carbonized utilization in cold areas? - A 6-year field-located trial.

Biochar amendment can benefit rice growth, but the long-term effects of rice straw carbonized utilization (RSCU, biochar, and biochar-based fertilizer) on rice production in cold areas are still unclear. Herein, we conducted a field experiment over 6 years with four treatments: F (conventional fertilization) as the control, RB1 (biochar, 3 t·ha), RB2 (biochar, 6 t·ha), and RBF (biochar-based fertilizer, 0.75 t·ha).

Preparation of γ-phase pigment Red 170 through hydrothermal treatment and kaolin coating modification.

Research on the dynamics of crystal transformation can guide production practices and improve the coloration performance of pigment Red 170. As one of the most important azo dyes, the low hiding power, inferior weather resistance, thermal instability, and low flowability of pigment Red 170 limit its applications. To enhance these properties, it is essential to modify the surface of the pigment.