Multi-wavelength emission nitrogen-doped carbon dots as fluorescent nanosensing platform for the detection of ascorbic acid and their application in bioimaging tracking.

Vitamins are indispensable active components of the human body, and their abnormal levels are often closely related to various diseases. Therefore, searching for ultra-sensitive and accurate vitamin detection strategies is essential and significant for clinical examination and diagnosis. In this paper, multi-wavelength emission fluorescent nitrogen-doped carbon dots (N-doped CDs) were synthesized by a one-step solvothermal method using four-leaf green fluorescent extract, O-phenylenediamine, and β-cyclodextrin as the raw materials, and N, N-dimethylformamide as the solvent.

Hydrogen Bond Network Assisted Ultrafast Ion Transport of Anion Exchange Membrane Grafting with Covalent Organic Frameworks for Hydrogen Conversion.

The development of anion exchange membranes (AEMs) capable of facilitating rapid hydroxide ion transport, while maintaining robust mechanical stability, is considered a key direction for advancing hydrogen energy conversion systems. Herein, we synthesized a series of AEMs by grafting covalent organic frameworks (COFs) onto triphenylpiperidine copolymer and systematically evaluated the performance of AEMs. The tailored COFs, characterized by an extensive hydrogen bond network and high micro-porosity, created interconnected high-speed ion transport channels, significantly reducing the resistance to hydroxide ion conduction.

Developing and Applying the BE-FAIR Equity Framework to a Population Health Predictive Model: A Retrospective Observational Cohort Study.

Background: Population health programs rely on healthcare predictive models to allocate resources, yet models can perpetuate biases that exacerbate health disparities among marginalized communities.

Objective: We developed the Bias-reduction and Equity Framework for Assessing, Implementing, and Redesigning (BE-FAIR) healthcare predictive models, an applied framework tested within a large health system using a population health predictive model, aiming to minimize bias and enhance equity.

Design: Retrospective cohort study conducted at an academic medical center.

Constructing Z-scheme between graphite nitride carbon and supramolecular zinc porphyrin to promote photocatalytic H evolution.

The separation and transport of charge carriers between heterojunction interfaces are key factors that constrain their photocatalytic activity. In current study, a new binary heterojunction (BCN-N-SA) composed of g-CN nanosheet (BCN-N) and self-assembled supramolecular zinc porphyrin (SA-ZnTCPP) was successfully synthesized for photocatalytic hydrogen evolution (PHE) from water splitting. The optimal PHE rate of BCN-N-SA reaches 23.

Metabolomics based analysis reveals the therapeutic effects of Incarvillea arguta (Royle) Royle aqueous extract against alcohol-induced liver injury.

Background: Alcohol-induced liver injury (ALI) poses a significant threat to global human health. The Chinese Yi medicine Liangtoumao (LTM), which originated from the whole plant of Incarvillea arguta Royle (Royle), has been widely used by the Yi ethnic group to prevent and treat ALI and other liver diseases. However, its effectiveness and mechanisms are still under-researched.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma.

Renal cell carcinoma (RCC) is a highly malignant and common urological tumor. In our previous study, we reported the upregulation of PRR11 in RCC, emphasizing its important role in cell cycle regulation and apoptosis. In this follow-up study, we aim to further investigate the carcinogenic mechanism of PRR11.

COVID-19 caused by the Omicron variant in lung transplant recipients: a single center case series.

Background: Although coronavirus disease 2019 (COVID-19) is no longer classified as a Public Health Emergency of International Concern by World Health Organization, its global impact persists. Data on its impact in lung transplant recipients (LTRs) from China remain limited. This study aims to share clinical experiences and provide insights into managing LTRs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

The High Expression of PD-1 Defines A Subpopulation of Tfh Cells Responding to COVID-19 Vaccine in Humans.

Inactivated coronavirus disease 2019 (COVID-19) vaccines and receptor binding domain subunit (RBD-subunit) booster vaccination can induce effective humoral immune response. CD4+ T helper cells are essential in helping B cells and antibody response. However, the response of CD4+ T cells to booster vaccination, especially the virus-induced T follicular helper (Tfh) cells, needs to be better characterized.

Potential biological roles of exosomal non-coding RNAs in breast cancer.

Breast cancer (BC) is one of the most common malignant tumors among women, accounting for 24.5% of all cancer cases and leading to 15.5% of cancer-related mortality.

Developing Eco-Friendly, High-Performance Soy Protein Plywood Adhesive via Core-Shell Hybridization and Borate Chemistry.

Developing eco-friendly, high-performance adhesives is crucial for sustainable industrial applications but remains a significant challenge. Herein, a synergistic strategy combining core-shell hybridization and borate chemistry was employed to fabricate a multifunctional soy protein (SPI) adhesive with excellent adhesion. Specifically, a reactive core-shell hybrid (POSS-U) was synthesized via free-radical polymerization using octavinyl-POSS as the core and urushiol (U) as the shell.

Experimental Study on Hydrogen-Induced Crack Propagation of X80 Steel Under Alternating Pressure Fluctuations.

When hydrogen is transported in a pipeline, the fatigue loading in the pipeline will enhance hydrogen accumulation and diffusion, thus increasing the risk of hydrogen-induced fracture. In this study, specimens are subjected to cyclic loading within an autoclave, where hydrogen gas pressure is varied to examine its impact on fatigue crack growth. The influence of hydrogen pressure and stress variations on the fatigue crack growth rate is investigated.

Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway.

The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) regulates glucolipid metabolic disorder remains unclear. In this study, we first assessed the effect of VDMY on various physiological parameters in mice, followed by RNA sequencing (RNA-seq) to identify key signaling pathways affected by VDMY in liver tissues.

Aspirin Eugenol Ester Alleviates Energy Metabolism Disorders by Reducing Oxidative Damage and Inflammation in the Livers of Broilers Under High-Stocking-Density Stress.

This study aimed to evaluate the effects of aspirin eugenol ester (AEE) on growth performance, oxidative liver damage, inflammation, and liver metabolomics in broilers under high-stocking-density (HSD) stress. A total of 360 broilers were divided into four groups: normal density (ND, 14/m), high density (HD, 22/m), ND-AEE (ND + 0.01% AEE), and HD-AEE (HD + 0.

Isothermal Equation of State of Polyether Ether Ketone (PEEK) by Optical Imaging Method in Diamond Anvil Cell.

Polymers serve as important functional materials in various environments, including high-pressure conditions. However, the behavior of polymers under high pressure is currently less understood. In this study, the isothermal equation of state of polyether ether ketone (PEEK), an important polymer, was measured using the diamond anvil cell technique at up to 8 GPa.

Body Temperature Detection of Group-Housed Pigs Based on the Pairing of Left and Right Ear Roots in Thermal Images.

Body temperature is a critical indicator of pig health. This study proposes a non-contact method for detecting body temperature in group-housed pigs by extracting temperature data from thermal images of ear roots. Thermal images in the drinking trough area were captured using a thermal camera, with real-time data transmitted to a monitoring room via optical fibers.

Programmable 2H-MoTe FGFET-Based CMOS Array.

A programmable 2H-MoTe floating-gate field-effect transistor (FGFET)-based complementary metal oxide semiconductor (CMOS) array has been fabricated on the grown substrate. Coplanar grown metallic 1T'-MoTe serves as the source and drain electrodes. The conductive type of the 2H-MoTe channel is manipulated by a top-gate engineering method.

Synergistic regulation of colon microflora and metabolic environment by resistant starch and sodium lactate in hyperlipidemic rats.

Type 3 resistant starch (RS3) regulates diet-related metabolic diseases by promoting intestinal short-chain fatty acids (SCFAs) and lactate production, and facilitating microbial lactate-to-butyrate fermentation. However, its precise in vivo mechanism remains unclear. Therefore, we studied the effects of type 3 lotus seed resistant starch (LRS3) and sodium lactate (SL) on colonic microbiota composition, metabolism, and lipid parameters.

Learning the Difference of Few-Shot Food Data Using Multivariate Knowledge-Guided Variational Autoencoder.

Recent advancements in food image recognition have underscored its importance in dietary monitoring, which promotes a healthy lifestyle and aids in the prevention of diseases such as diabetes and obesity. While mainstream food recognition methods excel in scenarios with large-scale annotated datasets, they falter in few-shot regimes where data is limited. This paper addresses this challenge by introducing a variational generative method, the Multivariate Knowledge-guided Variational AutoEncoder (MK-VAE), for few-shot food recognition.

Artificial intelligence-based automated surgical workflow recognition in esophageal endoscopic submucosal dissection: an international multicenter study (with video).

Background: Endoscopic submucosal dissection (ESD) is a crucial yet challenging multi-phase procedure for treating early gastrointestinal cancers. This study developed an artificial intelligence (AI)-based automated surgical workflow recognition model for esophageal ESD and proposed an innovative training program based on esophageal ESD videos with or without AI labels to evaluate its effectiveness for trainees.

Methods: We retrospectively analyzed complete ESD videos collected from seven hospitals worldwide between 2016 and 2024.

Facile preparation of fluorescent carbon dots from water caltrop shells and their application in amikacin sensing.

Amikacin (AMK) effectively treats infections from Gram-negative bacilli and penicillin-resistant . However, prolonged administration of AMK may result in adverse effects such as nausea, headache, ototoxicity, and hearing loss, necessitating a reliable detection method. Carbon dots (CDs), known for their excellent optical properties, are a promising fluorescent probe.

Epstein-Barr Virus and Human Papillomavirus Infection in Papillary Thyroid Carcinoma: A Correlation Study.

Introduction: This study explores the presence and clinical significance of Epstein- Barr Virus (EBV) and Human Papillomavirus (HPV) in papillary thyroid carcinoma (PTC). EBV and HPV are known to contribute to various cancers, but their roles in thyroid cancer development are debated.

Method: Paraffin-embedded tissue blocks from PTC patients (n=255) who underwent thyroid surgery between 2020 and 2021 were analyzed for EBV and HPV DNA using PCR-based methods.

Hierarchical and distinct biological motion processing in macaque visual cortical areas MT and MST.

It is widely accepted that biological motion (BM) perception involves the posterior superior temporal sulcus (pSTS). Yet, how individual neurons and neural circuits in pSTS encode BM remains unclear. Here we combined electrophysiological recordings with neural network modeling to elucidate BM computations in two subregions of pSTS.

Gold nanocubes etching enhanced light scattering immunoassay for highly sensitive detection of Staphylococcus aureus enterotoxin A.

An innovative light scattering immunoassay was developed using an AuNPs etching strategy. Three types of anisotropic gold nanoparticles, including gold nanocubes, nanorods, and nanoflowers with distinct morphologies, were utilized to investigate how these morphological differences affect the sensitivity of light scattering signal transduction. Based on theoretical insights into light scattering and electromagnetic fields, gold nanocubes were identified as the optimal probes for enhancing light scattering signal transduction and were employed to construct an immunoassay for detecting staphylococcal enterotoxin A (SEA).

Treatment of femoropopliteal arterial lesions with excimer laser atherectomy and drug-coated balloon.

ObjectivesProximal to mid-term effects of contrast excimer laser atherectomy (ELA) + drug-coated balloon (DCB) versus PTA + drug-coated balloon (DCB) in the treatment of new lesions in the femoral popliteal segment of patients with lower extremity arteriosclerosis and occlusion.MethodsThe clinical data of 105 patients with CT-confirmed femoropopliteal segment lesions (Rutherford grades 3-6) were retrospectively analyzed. According to the computerized randomization method, 58 patients (44 males, mean 72.