Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice.

Macrophages play a central role in antitumor immunity, making them an attractive target for gene therapy strategies. However, macrophages are difficult to transfect because of nucleic acid sensors that can trigger the degradation of foreign plasmid DNA. Here, we developed a macrophage-specific editing (MAGE) system by which compact plasmid DNA encoding a CasRx editor can be delivered to macrophages by a poly(β-amino ester) (PBAE) carrier to bypass the DNA sensor and enable RNA editing in vitro and in vivo.

Non-traumatic lumbar spondylolysis with contralateral pedicle and lamina fracture: a case report and review of the literature.

Lumbar spondylolysis of a single lumbar vertebra with a fracture of the pedicle on the opposite side, as well as fractures of both pedicles and bilateral spondylolysis, have been extensively reported in the literature. These cases are commonly linked to factors such as trauma, sports activities, and spinal surgeries. We report a unique case of a unilateral lumbar spondylolysis with a fracture on the opposite side including the pedicle and lamina.

Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity.

Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset.

PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner.

Small extracellular vesicles (sEVs), carrying PD-L1, have been implicated in immune evasion and tumor progression. However, understanding how PD-L1 sEVs are secreted still needs to be improved. We found that the secretion dynamics of PD-L1 sEVs is similar to that of other sEVs.

Global burden of stroke attributable to dietary risk factors in the GBD 2021 study.

Objective: We sought to assess the impact of dietary risk on the worldwide burden of stroke, focusing specifically on ischemic stroke.

Methods: Utilizing information from the Global Burden of Disease Study 2021 (GBD2021), we evaluated the age-standardized death rate (ASDR), the age-standardized disability-adjusted life years (DALYs) rate, and the age, sex, and regional distribution of the estimated annual percentage change (EAPC) of the stroke burden linked to dietary risk from 1990 to 2021.

Results: The global overall ASDR and the age-standardized DALY rate per 100,000 population for stroke linked to dietary risk from 1990 to 2021 exhibited a declining trend [EAPC = -1.

Adequacy of EUS-guided fine-needle aspiration and fine-needle biopsy for next-generation sequencing in pancreatic malignancies: A systematic review and meta-analysis.

Background And Objectives: A majority of pancreatic malignancies are unresectable at the time of presentation and require EUS-guided fine-needle aspiration or fine-needle biopsy (EUS-FNA/FNB) for diagnosis. With the advent of precision therapy, there is an increasing need to use EUS-FNA/FNB sample for genetic analysis. Next-generation sequencing (NGS) is a preferred technology to detect genetic mutations with high sensitivity in small specimens.

Mesoporous Co-MoS with sulfur vacancies: A bifunctional electrocatalyst for enhanced water-splitting reactions in alkaline media.

As a graphene-like layered material, molybdenum disulfide (MoS), has attracted increasing attentions for its promising application in electrocatalysis. Whereas MoS still suffers from the sluggish reaction kinetics in oxygen evolution reaction (OER) due to the low density of active sites in most exposed planes. In this work, high density of active sites on MoS basal planes has been obtained by synthesizing mesoporous MoS with Co doping and sulfur vacancies (V).

A cross-scale transfer learning framework: prediction of SOD activity from leaf microstructure to macroscopic hyperspectral imaging.

Superoxide dismutase (SOD) plays an important role to respond in the defence against damage when tomato leaves are under different types of adversity stresses. This work employed microhyperspectral imaging (MHSI) and visible near-infrared (Vis-NIR) hyperspectral imaging (HSI) technologies to predict tomato leaf SOD activity. The macroscopic model of SOD activity in tomato leaves was constructed using the convolutional neural network in conjunction with the long and short-term temporal memory (CNN-LSTM) technique.

The associations between the energy and timing of sugar-sweetened beverage intake and phenotypic age acceleration in U.S. adults: a cross-sectional survey of NHANES 2007-2010.

Objectives: The relationship between sugar-sweetened beverage (SSB) intake and phenotypic age acceleration (PhenoAgeAccel) is unclear. The aim of this study was to explore the associations between the energy and timing of SSB intake and PhenoAgeAccel in adults.

Methods: A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010, which involved U.

Cardiovascular mortality risk among small bowel adenocarcinoma patients: a population-based study.

Background: The objective of this research is to statistically assess the risk of cardiovascular mortality (CVM) between patients with small bowel adenocarcinoma (SBA) and the general population. Additionally, it aims to identify CVM-associated risk factors among individuals with SBA.

Methods: Data obtained between 2000 and 2017 on SBA patients from the Surveillance, Epidemiology, and End Results (SEER) database were examined.

Validation of a Deep Learning-Based Method for Accelerating Susceptibility-Weighted Imaging in Clinical Settings.

Susceptibility-weighted imaging (SWI) has been widely used in clinical contexts, in which the speed of acquisition is frequently a critical issue. In this study, we aim to test the feasibility of a deep learning (DL)-based reconstruction method for accelerating SWI acquisition in clinical settings. A total of 61 subjects were consecutively enrolled.

Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion.

Background: Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early and accurate diagnosis is crucial for effective treatment and prognosis. Traditional invasive procedures such as image-guided prostate biopsy often cause discomfort and complications, deterring some patients from undergoing these necessary tests.

Effects of Increasing the Nitrogen-Phosphorus Ratio on the Structure and Function of the Soil Microbial Community in the Yellow River Delta.

Nitrogen (N) deposition from human activities leads to an imbalance in the N and phosphorus (P) ratios of natural ecosystems, which has a series of negative impacts on ecosystems. In this study, we used 16s rRNA sequencing technology to investigate the effect of the N-P supply ratio on the bulk soil (BS) and rhizosphere soil (RS) bacterial community of halophytes in coastal wetlands through manipulated field experiments. The response of soil bacterial communities to changing N and P ratios was influenced by plants.

Engineered Strategies for Lipid Droplets-Targeted AIEgens Based on Tetraphenylethene.

Lipid droplets (LDs), once regarded as inert fat particles, have been ignored by scientific researchers for a long time. Now, studies have shown that LDs are dynamic organelles used to store neutral lipids in cells and maintain cell stability. The abnormality of intracellular LDs usually causes metabolic disorders in the body, such as obesity, atherosclerosis, diabetes, and cancer, so the LDs have attracted wide attention.

Subtle Structural Modifications Spanning from EP4 Antagonism to EP2/EP4 Dual Antagonism: A Novel Class of Thienocyclic-Based Derivatives.

The development of dual prostaglandin E receptors 2/4 (EP2/EP4) antagonists represents an attractive strategy for cancer immunotherapy. Herein, a series of 4,7-dihydro-5-thieno[2,3-]pyran derivatives with potent EP2/EP4 dual antagonism were discovered by fine-tuned structural modifications. The biphenyl side chain was found to be the key pharmacophore for the transition from EP4 antagonism to EP2/EP4 dual antagonism.

Comparative analysis of the performance, egg quality and ovarian immune function of fast and slow feather strains in tianfu green shell laying hens at various stages of egg production.

This objective of this experiment was to compare and evaluate the performance, egg quality, and immune function of Tianfu green shell laying hens with varying feather growth rates, in order to provide a reference for their rational utilization. A total of 120 one-day-old healthy Tianfu green shell laying hens were classified into the early-feathering (EF) and late-feathering (LF) groups through phenotypic identification of feather length and qPCR molecular identification. Each group was subdivided into four replicates, with 30 chickens in each replicate.

APOM Modulates the Glycolysis Process in Liver Cancer Cells by Controlling the Expression and Activity of HK2 via the Notch Pathway.

The metabolic pathway of aerobic glycolysis in tumor cells has garnered significant attention in tumor research because of its high activation in cancer cells. Previous research conducted by our team has demonstrated that Apolipoprotein M (APOM) exhibits potential as a factor against liver cancer. However, further investigations are needed to elucidate the precise approach and mechanism that are involved in this process.

The transcription factor NnNAC100 positively regulates amylopectin biosynthesis by activating NnSBEII in the rhizome of Nelumbo nucifera Gaertn.

NnNAC100-NnSBEII modules enhance starch content of the rhizome in Nelumbo nucifera Gaertn. Nelumbo nucifera Gaertn. is a popular aquatic vegetable and traditional Chinese medicine whose quality and taste are mainly determined by the starch.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Effect of 2-Way Social Support and Social Networks on the General Well-Being of Older Adults: A Latent Profile Analysis.

Aims: To examine the profiles of general well-being in older adults and their related sociodemographic characteristics and to explore the association of these profiles with 2-way social support and social networks.

Design: This was a cross-sectional study.

Methods: In total, 411 older adults were recruited through convenience sampling from Zhejiang Province, southeast China.

Corrigendum: Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.

[This corrects the article DOI: 10.3389/fphar.2023.

Cross sectional associations of physical activity and sleep with mental health among Chinese university students.

Objective: This study aimed to examine the levels of physical activity (PA), sleep, and mental health (MH), specifically depression, anxiety, and stress, among Chinese university students. It also aimed to analyze the influencing factors of MH, providing a theoretical foundation for developing intervention programs to improve college students' mental health.

Methods: A stratified, clustered, and phased sampling method was employed.