Magnetar emergence in a peculiar gamma-ray burst from a compact star merger.

The central engine that powers gamma-ray bursts (GRBs), the most powerful explosions in the universe, is still not identified. Besides hyper-accreting black holes, rapidly spinning and highly magnetized neutron stars, known as millisecond magnetars, have been suggested to power both long and short GRBs. The presence of a magnetar engine following compact star mergers is of particular interest as it would provide essential constraints on the poorly understood equation of state for neutron stars.

PDPN+ cancer-associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF-κB activation and the CCL2-ACKR1 axis.

Cancer-associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which are significantly enriched in metastatic lesions and secrete chemokine (CC-motif) ligand 2 (CCL2). Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF-κB signaling pathway.

LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36.

Limb expression 1-like protein (LIX1L) is an essential player in liver disorders, but its function in metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC) progression remains obscure. Here, we identify LIX1L as a key integrative regulator linking lipid metabolism and inflammation, adipose tissue and hepatic microenvironment, which promotes MASH progression. LIX1L significantly upregulates in MASH patients, mouse models, and palmitic acid-stimulated hepatocytes.

Turing covalent organic framework membranes via heterogeneous nucleation synthesis for organic solvent nanofiltration.

Although covalent organic frameworks (COFs) demonstrate notable potential for developing advanced separation membranes, contemporary COF membranes still lack controlled stacking and highly efficient sieving. Here, Turing-architecture COF membranes were constructed by engineering a reaction-diffusion assembly process via heterogeneous nucleation synthesis with tannic acid (TA). TA covalently binds with amine monomers to form a composite precursor with increased reactivity and decreased diffusivity.

A Sunlight-Interference-Immune Artificial Optoelectronic Synaptic Device for Visual Perception and Memory.

The artificial photoelectric synaptic devices integrating optical signal response and data processing functions enable the simulation of the human visual system. However, the optical modulation behavior of photoelectronic synaptic devices is susceptible to interference from sunlight background, significantly hindering their applications in optical modulation. To address this issue, a Ni/AlYN/ITO structure for sunlight-interference-free artificial synaptic memristor was designed and fabricated, and the application in photoelectric modulation was demonstrated.

Boosting lithium/magnesium separation performance of selective electrodialysis membranes regulated by enamine reaction.

Monovalent cation exchange membranes (MCEMs) have progressively played an important role in the field of ion separation. However, according to transition state theory (TST), synchronously tuning the enthalpy barrier (△H) and entropy barrier (△S) for cation transport to improve ion separation performance is challenging. Here, the enamine reaction between the -NH- and -CHO groups is applied to regulate the subsequent Schiff-base reaction between the -CHO and -NH groups, which reduces the positive charges of the selective layer but increases the steric hindrance.

Pink1-dependent mitophagy in vascular smooth muscle cells: Implications for arterial constriction.

Hypertension is a major global health issue, contributing to significant cardiovascular morbidity and mortality. Mitochondrial dysfunction, particularly through dysregulated mitophagy, has been implicated in the pathogenesis of hypertension. We wanted to find out the relationship between mitochondrial autophagy and changes in arterial smooth muscle cell tension and the molecular mechanism.

Evaluating the significance of ECSCR in the diagnosis of ulcerative colitis and drug efficacy assessment.

Background: The main challenge in diagnosing and treating ulcerative colitis (UC) has prompted this study to discover useful biomarkers and understand the underlying molecular mechanisms.

Methods: In this study, transcriptomic data from intestinal mucosal biopsies underwent Robust Rank Aggregation (RRA) analysis to identify differential genes. These genes intersected with UC key genes from Weighted Gene Co-expression Network Analysis (WGCNA).

Prognostic significance of LRPPRC and its association with immune infiltration in liver hepatocellular carcinoma.

Background: Leucine rich pentatricopeptide repeat containing (LRPPRC) protein is a multifunctional protein involved in cell cycle progression and tumor development. However, its prognostic significance and association with immune infiltration in Liver hepatocellular carcinoma (LIHC) remain unclear.

Methods: We utilized transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) databases of LIHC patients to investigate the potential pro-cancer role of LRPPRC, including differential expression of LRPPRC in LIHC, prognostic value, clinicopathological features, immune cell infiltration relevance and function enrichment analysis.

The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.

Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, regulates UPS-mediated protein degradation and tumor progression in some cancer types. However, the biological function and mechanism of UBTD1 are far from being well elucidated, and its role in CRC has not been explored yet.

Cooling Condition Effect on Spectral Properties and Smartphone-Based Anticounterfeiting Application of ZnGaGeO/Cr Phosphors.

The influence of cooling history for the ZnGaGeO/Cr phosphors prepared by solid state reaction on the spectral properties was discovered, and an anticounterfeiting scheme based on the identification with smartphone was proposed and experimentally demonstrated using the studied phosphors. A combination of color-tunable visible fluorescence emission and near-infrared (NIR) afterglow emission in ZnGaGeO/ mol % Cr( = 0, 0.05, 1, 2, 3, and 4) phosphors to achieve multimode anticounterfeiting was reported.

The Flavonoid Glycoside from Hance Alleviates Alcoholic Liver Injury by Inhibiting Ferroptosis in an AMPK-Dependent Manner.

Hance is a vegetative food and can be used as a folk beverage or soup to clear liver toxins and prevent liver damage. However, the components and effects of Hance in alcohol-induced liver injury were unknown. This study aimed to obtain abundant phytochemicals from Hance and identify the potency of the isolates in preventing alcohol-induced liver injury.

A simulation study of transcranial magnetoacoustic stimulation of the basal ganglia thalamic neural network to improve pathological beta oscillations in Parkinson's disease.

Background: Parkinson's disease (PD) is a common neurodegenerative disease. Transcranial magnetoacoustic stimulation (TMAS) is a new therapy that combines a transcranial focused acoustic pressure field with a magnetic field to excite or inhibit neurons in targeted area, which suppresses the abnormally elevated beta band amplitude in PD states, with high spatial resolution and non-invasively.

Objective: To study the effective stimulation parameters of TMAS mononuclear and multinuclear stimulation for the treatment of PD with reduced beta band energy, improved abnormal synchronization, and no thermal damage.

Lefamulin Overcomes Acquired Drug Resistance via Regulating Mitochondrial Homeostasis by Targeting ILF3 in Hepatocellular Carcinoma.

Acquired resistance represents a critical clinical challenge to molecular targeted therapies such as tyrosine kinase inhibitors (TKIs) treatment in hepatocellular carcinoma (HCC). Therefore, it is urgent to explore new mechanisms and therapeutics that can overcome or delay resistance. Here, a US Food and Drug Administration (FDA)-approved pleuromutilin antibiotic is identified that overcomes sorafenib resistance in HCC cell lines, cell line-derived xenograft (CDX) and hydrodynamic injection mouse models.

Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats.

Ginsenoside compound K (GCK) possesses a glucocorticoid (GC)-like structure and functions as an agonist of the glucocorticoid receptor (GR), thereby exerting anti-inflammatory effects through GR activation. However, it remains unclear whether GCK leads to hyperglycemia, which is a known adverse reaction associated with classical GCs. In this study, we have successfully demonstrated that GCK exerts its anti-inflammatory effects in a rat model of adjuvant arthritis without impacting gluconeogenesis and pentose phosphate pathways, thus avoiding any glucose metabolism disorders.

Research progress in the treatment of inflammatory bowel disease with natural polysaccharides and related structure-activity relationships.

Inflammatory bowel disease (IBD) comprises a group of highly prevalent and chronic inflammatory intestinal tract diseases caused by multiple factors. Despite extensive research into the causes of the disease, IBD's pathogenic mechanisms remain unclear. Moreover, side effects of current IBD therapies restrict their long-term clinical use.

Green R & D investment, ESG reporting, and corporate green innovation performance.

Given the contradictory empirical evidence on the relationship between green R&D expenditure and corporate Green Innovation performance (GIP), The present research study is a distinctive investigation into the moderating impacts of ESG reporting on this relationship. We utilized a data collection of 3,846, firm-year observations of A-share listed firms in China from 2016 to 2022 from CSMAR and Bloomberg databases. The firm's Corporate GIP is assessed and measured by looking at the total quantity of green patents.

Luminescence properties and Judd-Ofelt analysis of Tb doped SrYTaO double perovskite phosphors for white LED applications.

A series of Tb-doped SrYTaO double perovskite phosphors (SYT:Tb) were synthesized using a conventional solid-state reaction method. A strong green emission was observed in the SYT:Tb phosphors, and the optimal doping concentration of Tb was confirmed to be 5 mol%. The electric dipole-dipole interaction was ascribed to be the main mechanism for the luminescence concentration quenching.

Identification of glycosyltransferase-related genes signature and integrative analyses in patients with ovarian cancer.

Background: Glycosyltransferases (GT) play a crucial role in glycosylation reactions, and aberrant expression of glycosyltransferase-related genes (GTs) leads to abnormal glycosylation, which is associated with tumor progression. However, the prognostic value of aberrant expression of GTs in ovarian cancer (OC) and the correlation between GTs and tumor microenvironment (TME) remain unknown.

Methods: TCGA and GSE53963 databases were used to obtain data on OC patient samples.

Genome-wide identification, expression and function analysis of the gene family in tulip ().

Currently, soil heavy metal contamination is a severe issue, particularly with Cd pollution. The metal tolerance protein (MTP) proteins, as plant divalent cation transporters, play a crucial role in the transport and tolerance of heavy metals in plants. This study conducted comprehensive identification and characterization of the gene family in the tulip.