New Antifouling Dual Iron-Based Photo-Fenton Catalytic Membrane Dedicated to Long-Term Treatment of Oils and Dyes.

Combining the photo-Fenton catalytic reaction with membrane separation technology can effectively treat oils and dyes in water. However, single iron-based catalysts suffer from limited photogenerated carrier utilization and slow Fe/Fe redox reactions, leading to membrane contamination. In this study, iron oxyhydroxide and Prussian blue were grown on a PVDF membrane, optimizing electron transfer to improve the catalytic efficiency (the methylene blue degradation efficiency was nearly 50% in 10 min and the reaction rate constant was 0.

On-chip near-infrared multi-gas sensing using chalcogenide anti-resonant hollow-core waveguides.

On-chip infrared spectroscopic gas sensing using a hollow-core anti-resonant reflecting optical waveguide (ARROW) with a large external confinement factor (ECF) was rarely reported due to the complex fabrication process and polarization dependence. Alternatively, we proposed ARROW gas sensors using chalcogenide (ChG) anti-resonant layers which require thermal evaporation and epoxy resin bonding for fabrication instead of the complicated wafer bonding process. Polarization characteristics and ethylene (CH) sensing performance at 1.

Tungsten Adsorption on Goethite: Insights from First-Principles Molecular Dynamics Simulations.

The environmental fate of tungsten (W) has received particular attention due to its increasing utilization and potential health hazards. Adsorption on minerals is considered as a major factor in governing tungsten's mobility and bioavailability. Goethite, a highly stable iron oxide in soils and sediments, is pivotal in determining tungsten's environmental behavior.

An early prediction model for gestational diabetes mellitus created using machine learning algorithms.

Objective: To investigate high-risk factors for gestational diabetes mellitus (GDM) in early pregnancy through an analysis of demographic and clinical data, and to develops a machine-learning-based prediction model to enhance early diagnosis and intervention.

Methods: A retrospective study was performed involving 942 pregnant women. A stacking ensemble (machine learning [ML]) was applied to demographic and clinical variables, creating a predictive model for GDM.

Forsythiaside A Ameliorates Oxidative Damage Caused by Cerebral Ischemia Through the Nrf2/HO-1 Signaling Pathway.

Forsythiaside A (FA) has anti-inflammatory and antioxidant properties. The aim of this study was to explore the antioxidant effects and mechanisms of FA in ischemic stroke (IS). In this work, IS-related genes were obtained through GEO, GeneCards, TTD, CTD, DrugBank, and MalaCards databases.

Diffusion-Weighted Imaging-Based Radiomics Features and Machine Learning Method to Predict the 90-Day Prognosis in Patients With Acute Ischemic Stroke.

Objectives: The evaluation of the prognosis of patients with acute ischemic stroke (AIS) is of great significance in clinical practice. We aim to evaluate the feasibility and effectiveness of diffusion-weighted imaging (DWI) image-based radiomics features and machine learning methods in predicting 90-day prognosis among patients with AIS.

Patients And Methods: We enrolled a total of 171 patients with AIS in this study, including 134 patients with a good prognosis and 37 patients with a poor prognosis, and collected the patients' clinical and DWI image data.

Identification of novel tetrabromobisphenol A byproducts in industrial chemicals and the environment near a manufacturing site: an overlooked source of novel pollutants.

To evaluate the migration, transformation, and fate of tetrabromobisphenol A (TBBPA) in the environment, the transformation/degradation (T/D) products of TBBPA and byproducts of industrial production should be distinguished. Herein, 7 reported T/D products (R1-R7) and 7 novel byproducts (N1-N7) of TBBPA were identified in industrial-grade TBBPA chemicals by using high-performance liquid chromatography coupled ion trap mass spectrometry and high-resolution mass spectrometry with a suspect screening strategy. The possible formation pathways of these byproducts were attributed to the bromination, debromination, methylation, demethylation, hydroxylation, substitution, and radical coupling reactions of bisphenol A (BPA), BPA impurities, and TBBPA.

Infrared In-Sensor Computing Based on Flexible Photothermoelectric Tellurium Nanomesh Arrays.

The inherent limitations of traditional von Neumann architectures hinder the rapid development of internet of things technologies. Beyond conventional, complementary metal-oxide-semiconductor technologies, imaging sensors integrated with near- or in-sensor computing architectures emerge as a promising solution. In this study, the multi-scale van der Waals (vdWs) interactions in 1D tellurium (Te) atomic chains are explored, leading to the deposition of a photothermoelectric (PTE) Te nanomesh on a polymeric polyimide substrate.

From reticulated platelets to immature platelet fraction: structure, function, and clinical applications.

In comparison to mature platelets, reticulated platelets (RPs) are newly released from the bone marrow and exhibit a larger size, higher reactivity, and a greater quantity of RNA, and can be an agile indicator of platelet turnover. The transcriptome associated with platelet function is significantly upregulated in RPs, which is a possible explanation for RPs intrinsic hyper-reactivity. We presented a comprehensive overview of the detection techniques for RPs.

Application of large language models in healthcare: A bibliometric analysis.

Objective: The objective is to provide an overview of the application of large language models (LLMs) in healthcare by employing a bibliometric analysis methodology.

Method: We performed a comprehensive search for peer-reviewed English-language articles using PubMed and Web of Science. The selected articles were subsequently clustered and analyzed textually, with a focus on lexical co-occurrences, country-level and inter-author collaborations, and other relevant factors.

Relationship between estimated pulse wave velocity and the risk of future sarcopenia in middle-aged and older Chinese adults: evidence from the China Health and Retirement Longitudinal Study.

Objective: Sarcopenia, common among older adults, is associated with adverse health outcomes. This study explores the relationship between estimated pulse wave velocity (ePWV), a marker of arterial stiffness, and sarcopenia to support the early diagnosis and prevention strategies.

Methods: Using data from two waves (2011 and 2015) of the China Health and Retirement Longitudinal Study (CHARLS), we conducted a nationally representative cohort study.

Total talectomy and reconstruction using unrestricted 3D printed prosthesis for pediatric talus hemangioendothelioma.

Background: Epithelioid hemangioendothelioma (EHE) is an ultra-rare vascular sarcoma with an extremely low incidence and prevalence, particularly in children. We report the case of a 9-year-old girl diagnosed with EHE. There are limited reconstruction methods available following total talus resection for vascular endothelioma of the talus, and the use of a 3D-printed talus prosthesis in pediatric cases has not been previously documented.

Preclinical study of inetetamab combined with atezolizumab to synergistically inhibit HER2 and PD-L1 in the treatment of ovarian cancer.

Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy. Precision treatments are crucial for improving patient survival. This research explored the potential anti-tumor effects of combining inetetamab and atezolizumab for HER2 EOC patients.

Increased pathogenicity and transmissibility in hamsters of all age groups reveal an underestimated perniciousness of severe acute respiratory syndrome coronavirus 2 EG.1 variant.

The evolution and mutation of SARS-CoV-2 is elusive. However, the diverse pathogenicity and transmissibility of different SARS-CoV-2 Omicron/XBB variants are not well understood. We compared virological attributes of two XBB variants, XBB.

Complement is primarily activated in the lung in a mouse model of severe COVID-19.

studies and observational human disease data suggest the complement system contributes to SARS-CoV-2 pathogenesis, although how complement dysregulation develops in severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y) and a mouse model of COVID-19, we identify significant serologic and pulmonary complement activation post-infection. We observed C3 activation in airway and alveolar epithelia, and pulmonary vascular endothelia.

"Monitor-and-treat" that integrates bacterio-therapeutics and bio-optics for infected wound management.

Wound infections are one of the major threats to human health, accounting for millions of deaths annually. Real-time monitoring, accurate diagnosis, and on-demand therapy are crucial to minimizing complications and saving lives. Herein, we propose a "monitor-and-treat" strategy for infected wound management by integrating the emerging development of bacterio-therapeutics and bio-optics.

Exploration and verification of circulating diagnostic biomarkers in osteoarthritis based on machine learning.

Background: Osteoarthritis (OA) is a prevalent chronic joint condition. This study sought to explore potential diagnostic biomarkers for OA and assess their relevance in clinical samples.

Methods: We searched the GEO database for peripheral blood leukocytes expression profiles of OA patients as a training set to conduct differentially expressed gene (DEG) analysis.

Case report: A novel intronic likely pathogenic variant (c.941+75G > T) associated with congenital eyelid coloboma in one of the identical twin sisters.

Background: Congenital eyelid coloboma (CEC) is a rare genetic disease, manifesting as a congenital partial or total defect of the eyelid. In this study, we report a pedigree with CEC caused by a novel pathogenic variant in .

Case Report: The proband was a 3-year-old girl who presented with a congenital coloboma of the left upper eyelid, accompanied by hypoplasia of the ipsilateral eyebrow.

A dataset of three vine water status indicators, weather records and soil available water capacity components collected from a rain-fed Mediterranean vineyard.

This dataset contains three key indicators of vine water status: vine shoot growth index (iG-Apex), predawn leaf water potential (Ψpd), and carbon isotope ratio (δ13C). Additionally, it includes weather data and soil measurements. Spatial data files of studied fields, plots, and some vines' locations are also provided.

HighRPD: A high-altitude drone dataset of road pavement distress.

This dataset presents pavement distress data collected using high-altitude Unmanned Aerial Vehicles (UAVs) over road networks in Shanxi, China. The data collection involved capturing aerial images of road pavements with UAVs flying at high altitudes to efficiently cover large areas. A total of 11,696 high-resolution road pavement images were acquired and annotated with detailed distress information: 12,365 line annotations indicating linear cracks, 8239 block annotations marking block cracks, and 1412 pit annotations identifying potholes.

The protective role of muscone in the development of COPD.

Background: Muscone, a key component of musk, exhibits anti-inflammatory properties. However, its therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), remains largely unexplored. This study aimed to investigate whether Muscone could exert a protective effect in a mouse model of COPD .

Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats.

Introduction: Needle-free injection system (NFIS) is easy to operate and can decrease needle phobia. Besides, NFIS can increase the interaction of antigens in a more dispersed manner with immune cell at local injection site, which may improve the immune responses of mRNA vaccines. Although SARS-CoV-2 mRNA vaccines have great success, universal vaccines are urgently needed.

Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production.

Introduction: is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying -induced sepsis and its pathogenesis remain unclear. Acute respiratory failure is a leading cause of mortality in systemic infections, highlighting the need to better understand the host immune response and bacterial clearance mechanisms.

Efficacy and safety of trastuzumab deruxtecan in Chinese patients with HER2-positive and HER2-low advanced breast cancer: a multicenter, observational, real-world study.

Objective: Limited real-world efficacy and safety data exist regarding the use of trastuzumab deruxtecan (T-DXd) in the Chinese population with human epidermal growth factor receptor (HER2)-positive and HER2-low advanced breast cancer (BC). This multicenter, observational, real-world study aimed to evaluate the efficacy and safety of T-DXd for the treatment of Chinese patients with HER2-positive and HER2-low advanced BC.

Methods: The medical records of 61 patients were collected from The Second Hospital of Dalian Medical University, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing Jingxin Hospital, and Cancer Hospital of the Chinese Academy of Medical Sciences.

circDENND4C serves as a sponge for miR-200b to drive non-small cell lung cancer advancement by regulating MMP-9 expression.

Introduction: Lung cancer has a higher incidence and mortality rate than other cancers, especially non-small cell lung cancer (NSCLC), accounting for 85% of the cases. The role of the circDENND4C/miR-200b/matrix metalloproteinase-9 (MMP-9) regulatory axis in NSCLC remains largely unknown.

Methods: NSCLC cell lines were used to examine the expression of circDENND4C, miR-200b, and MMP-9 via qRT-PCR or Western blot.