Computational Pathology-Enabled Residual Tumor Estimation is a Prognostic Factor for Overall Survival in Anal Squamous Cell Carcinoma.

Anal squamous cell carcinoma (SCC) incidence has increased, and treatment has shifted from surgery to chemoradiotherapy (CRT), with salvage abdominoperineal resection (APR) being reserved for persistent/recurrent cases. This study evaluates the utility of different Tumor Regression Scoring Systems (TRSS) in predicting survival in anal SCC patients, using pathologists' observations and digital pathology. Cases managed surgically from 2005 to 2019 were collected.

Atherosclerotic plaque evolution predicts cerebral ischemic events in patients with intracranial atherosclerosis: a multicentre longitudinal study using high-resolution MRI.

Background: Intracranial atherosclerosis (ICAS) is the leading cause of ischemic stroke in Asians and the recurrent rate remains high despite the optimal medical treatment. This study aimed to confirm that follow-up high-resolution magnetic resonance imaging (hrMRI) provided essential values in predicting subsequent cerebral ischemic events in patients with ICAS.

Methods: Patients with moderate to severe stenosis in the middle cerebral artery (MCA) defined by magnetic resonance (MRA) or computed tomography angiography (CTA) were recruited from three centers retrospectively.

Trends and projections of Hepatitis A incidence in eastern China from 2007 to 2021: an age-period-cohort analysis.

Objective: This study aimed to analyze the trends in Hepatitis A incidence associated with age, period, and birth cohorts from 2007 to 2021 in Jiangsu Province, China, and projects the future burden through 2031.

Methods: Data on Hepatitis A cases in Jiangsu Province from 2007 to 2021 were obtained from the National Notifiable Disease Reporting System. Joinpoint regression analysis identified significant changes in incidence trends.

Global esophageal cancer epidemiology in 2022 and predictions for 2050: A comprehensive analysis and projections based on GLOBOCAN data.

Background: The burden of esophageal cancer varies across different regions of the world. The aim of this study is to analyze the current burden of esophageal cancer in 185 countries in 2022 and to project the trends up to the year 2050.

Methods: We extracted data on primary esophageal cancer cases and deaths from the GLOBOCAN 2022 database, which includes data from 185 countries.

Engineering p-Orbital States via Molecular Modules in All-Organic Electrocatalysts toward Direct Water Oxidation.

Oxygen evolution reaction (OER) is an indispensable anode reaction for sustainable hydrogen production from water electrolysis, yet overreliance on metal-based catalysts featured with vibrant d-electrons. It still has notable gap between metal-free and metal-based electrocatalysts, due to lacking accurate and efficient p-band regulation methods on non-metal atoms. Herein, a molecular modularization strategy is proposed for fine-tuning the p-orbital states of series metal-free covalent organic frameworks (COFs) for realizing OER performance beyond benchmark precious metal catalysts.

Is ultrasound-guided radiofrequency ablation a reliable treatment option for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus: a retrospective comparative study based on large-sample data.

Objective: To evaluate whether ultrasound-guided radiofrequency ablation (RFA) is reliable for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus (PTCI).

Methods: 431 patients who underwent ultrasound-guided RFA for unifocal T1aN0M0 papillary thyroid carcinoma (PTC) were divided by location of the lesion into the PTCI group (52 females, 7 males, mean age 43.79 ± 12.

Measuring anisotropy field of patterned soft magnetic films by anisotropic ferromagnetic resonances.

Patterned magnetic films have been applied widely in communication technology for meeting the development of miniaturization and high frequency. However, there has been some debate about the measuring of the anisotropy field, which is significant for deciding the electromagnetic performance. In the paper, we proposed the measurement of the anisotropy field using anisotropic ferromagnetic resonances in patterned permalloy magnetic films.

Application of reverse cumulative distribution curve and scaled logit model in determining optimal immunogenic dose and prediction of protection of EV71 vaccines.

Background: This study proposes the reverse cumulative distribution curve (RCDC) for optimal dose selection and a scaled logit model for estimating protection in EV71 vaccine development.

Research Design And Methods: Data were from a phase 2 trial involving infants and young children randomized to receive either 640 U with or without adjuvant, 320 U with adjuvant, 160 U with adjuvant EV71 vaccines, or placebo. RCDCs were constructed using neutralizing antibody titers 28 days post-vaccination.

Mesothelin expression prediction in pancreatic cancer based on multimodal stochastic configuration networks.

Predicting tumor biomarkers with high precision is essential for improving the diagnostic accuracy and developing more effective treatment strategies. This paper proposes a machine learning model that utilizes CT images and biopsy whole slide images (WSI) to classify mesothelin expression levels in pancreatic cancer. By combining multimodal learning and stochastic configuration networks, a radiopathomics mesothelin-prediction system named RPMSNet is developed.

Vacuum Filtration-Coated Silver Electrodes Coupled with Stacked Conductive Multi-Walled Carbon Nanotubes/Mulberry Paper Sensing Layers for a Highly Sensitive and Wide-Range Flexible Pressure Sensor.

Flexible pressure sensors based on paper have attracted considerable attention owing to their good performance, low cost, and environmental friendliness. However, effectively expanding the detection range of paper-based sensors with high sensitivities is still a challenge. Herein, we present a paper-based resistive pressure sensor with a sandwich structure consisting of two electrodes and three sensing layers.

PyWRKY40 negatively regulates anthocyanin synthesis in pear fruit.

The deposition of anthocyanin plays a crucial role in fruit pigmentation and serves as the primary determinant of pear quality. Various factors influence the synthesis of anthocyanins, with salicylic acid playing a significant role among them. However, the mechanism by which salicylic acid affects anthocyanin synthesis remains unclear.

Advanced BiVO-deoxygenated lignocellulosic photocatalyst for effective degradation of organic and heavy metal pollutants in aqueous system.

Bismuth vanadate (BiVO) is a common photocatalyst for water remediation, yet its powder form renders difficult to disperse, recycle, and regenerate, limiting photodegradation efficiency. In this study, a lignocellulosic-templated BiVO photocatalyst was fabricated from BiVO precursor and lignocellulose using a simple vacuum impregnation (w/o heat treatment on wood template). Results showed that the modified template retained original hierarchical structure with an increased specific surface area and reduced hemicellulose content, leading to a promising template for uniform distribution of BiVO.

Lateral intercalation-assisted ionic transport towards high-performance organic electrochemical transistor.

Efficiently mixed conduction between ionic and electronic charges stands to revolutionize the studies in organic electrochemical transistors (OECTs). However, inefficient ion transport due to the long-range injection and migration process in the bulk film presents challenges for enhancing the steady and transient performance of OECTs. In this work, we proposed a lateral intercalation-assisted ion transport strategy to assist volumetric ion charging, by introducing a striped microstructure in the conductive channel.

Investigating the molecular mechanisms of oocyte maturation and ovulation in Nile tilapia: A focus on the steroidogenic enzyme Cyp17a2.

Previous research has highlighted the significant role of progestins and glucocorticoids in fish oocyte maturation and ovulation. To clarify the molecular mechanisms underlying these processes, comprehensive investigations were conducted using a mutant Nile tilapia ( ) model. Analysis revealed pronounced Cyp17a2 expression in ovarian somatic cells of the tilapia.

Insights into the genetic architecture of the reciprocal interspecific hybrids derived from and .

Unlabelled: Chrysanthemums are versatile ornamental plants, and improving leaf and flower traits is an important breeding objective. Distant hybridization is a powerful method for plant breeding and genetic improvement, whereas the genetic basis in interspecific F progeny of chrysanthemums needs to be better understood for breeding purposes. In this study, the leaf and floral traits of the 273 reciprocal interspecific F hybrids of diploid (YSJ) and (JHN) were analyzed along with their SNP-derived genetic structure to elucidate the influence of differences in genetic background between the parents on the hybrid performance.

Chiral Nematic Graphene Films with a mesoporous Structure.

Ordering a crucial material like pure-graphene into the chiral nematic structure can potentially revolutionize the fields of photonics, chiral separation, and energy storage. However, the controlled fabrication of highly ordered graphene films with a long-range chiral nematic mesoporous structure is very challenging and as such, has not been achieved. Here, a chiral-template-directed chemical vapor deposition growth strategy is presented for the precise fabrication of mesoporous chiral nematic graphene films by using nanocrystalline cellulose as templates.

Honeycomb-like Microthermal Traps on a Photothermal Surface for Highly Efficient Solar Evaporation.

Solar evaporation is an ecofriendly and practical method for seawater desalination. The photothermal layer, which absorbs solar energy and converts it to thermal energy, plays a crucial role in enhancing the efficiency of the evaporator. However, structural design methods for photothermal layers are often complex and energy-intensive.

Magnetic-field-controlled positioning of magnetic domain wall in tie-shaped asymmetric nanowire and its application for magnetic field detection.

With topological spin texture, magnetic domain walls have soliton-like dynamic behaviors in magnetic nanowires, which can be used in information transmission and storage technology. Therefore, precisely controlling the dynamic behavior of the magnetic domain wall and its pinning behavior is one of the important technical challenges in realizing domain-wall-based spintronic devices. In this work, a geometrically defect-free scheme for domain wall pinning/depinning is proposed using micromagnetic simulations based on a tie-shaped asymmetric nanowire, which can precisely control the position of the magnetic domain wall in an external magnetic field.

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule-Binding Domain and Enhances Liquid-Liquid Phase Separation of Tau.

Liquid-liquid phase separation (LLPS) of tau protein can initiate its aggregation which is associated with Alzheimer's disease. The pathogenic mutation ΔK280 can enhance the aggregation of K18, a truncated tau variant comprising the microtubule-binding domain. However, the impact of ΔK280 on K18 LLPS and underlying mechanisms are largely unexplored.

Analysis of clinical application effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.

Objective: To evaluate the clinical effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.

Methods: This was a retrospective study. One hundred and fifty primiparae with spontaneous labor were selected at SSL Central Hospital of Dongguan City from July 10, 2021 to May 10, 2022 as the research objects and randomly divided into two groups (each n=75).