Regenerable AgNPs-CdSNWs/Nanofilm as SERS substrates for sensitive detection of carbamate pesticides.

The accurate detection of carbamate pesticides popularly employed in agricultural products is critical for reducing the threat of resultant residues to human health. In this work, a regenerable nanofilm used for SERS substrate was constructed by interfacially confined self-assembly incorporating CdS nanowires (CdSNWs) and Ag nanoparticles (AgNPs). The constructed AgNPs-CdSNWs/Nanofilm could significantly enhance the Raman signals of three carbamate pesticides (metolcarb, carbaryl and aldicarb-sulfone).

Dynamic changes in the gastrointestinal microbial communities of Gangba sheep and analysis of their functions in plant biomass degradation at high altitude.

Background: While Gangba sheep being well known for their unique flavour and nutritional value, harsh environmental factors negatively affect their growth and development, leading to poor productivity. The gastrointestinal tract microbiota plays an important role in host nutrient absorption and metabolism. The identification of dynamic changes in the gastrointestinal microbial communities and their functions is an important step towards improving animal production performance and health.

COph100: A comprehensive fundus image registration dataset from infants constituting the "RIDIRP" database.

Retinal image registration is vital for diagnostic therapeutic applications within the field of ophthalmology. Existing public datasets, focusing on adult retinal pathologies with high-quality images, have limited number of image pairs and neglect clinical challenges. To address this gap, we introduce COph100, a novel and challenging dataset known as the Comprehensive Ophthalmology Retinal Image Registration dataset for infants with a wide range of image quality issues constituting the public "RIDIRP" database.

Explainable machine learning framework for cataracts recognition using visual features.

Cataract is the leading ocular disease of blindness and visual impairment globally. Deep neural networks (DNNs) have achieved promising cataracts recognition performance based on anterior segment optical coherence tomography (AS-OCT) images; however, they have poor explanations, limiting their clinical applications. In contrast, visual features extracted from original AS-OCT images and their transform forms (e.

Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation.

Organ transplantation is the last-resort option to treat organ failure. However, less than 10% of patients benefit from this only option due to lack of major histocompatibility complex (MHC)-matched donor organs and 25%-80% of donated organs could not find MHC-matched recipients. T cell allorecognition is the principal mechanism for allogeneic graft rejection.

Chuanxiong Rhizoma regulates ferroptosis and the immune microenvironment in ischemic stroke through the JAK-STAT3 pathway.

Ferroptosis is linked to various pathological conditions; however, the specific targets and mechanisms through which traditional Chinese medicine influences ischemic stroke (IS)-induced ferroptosis remain poorly understood. In this study, data from the Gene Expression Omnibus and disease target databases (OMIM, GeneCards, DisGeNet, TTD, and DrugBank) were integrated with ferroptosis-related gene datasets. To identify key molecular targets of Chuanxiong Rhizoma (CX), drug ingredient databases, including PubChem and TCMBank, were employed to map CX-related targets (CX-DEGs-FRG and CX-IS-FRG).

Quantitative Assessment of Baseline Serum HDL-C to Predict Gout Flares During Urate-Lowering Therapy Initiation: A Prospective Cohort Study.

Purpose: Previous studies have linked high-density lipoprotein cholesterol (HDL-C) to gout, but little is known about the dose-effect relationship between serum HDL-C levels and gout flares. This study aimed to quantify the association between the two during urate-lowering therapy initiation and develop a regression equation to predict gout flares.

Patients And Methods: We conducted a prospective, observational, single-center cohort study of men with gout.

First record of the tetrablemmid armoured spiders (Araneae, Tetrablemmidae) from Xizang, China, with description of a new species.

Background: The spider genus Bourne, 1980 of the family Tetrablemmidae currently contains two species, Bourne, 1980 and Bourne, 1980. Both species are known from West Bengal, India.

New Information: A new species of is described from Xizang, China, sp.

Analysis of lung microbiota in pediatric pneumonia patients using BALF metagenomic next-generation sequencing: A retrospective observational study.

The contribution of the lung microbiota to pneumonia in children of varying severity remains poorly understood. This study utilized metagenomic next-generation sequencing (mNGS) technology to elucidate the characteristics of lung microbiota and their association with disease severity. This retrospective study analyzed bronchoalveolar lavage fluid (BALF) mNGS data of 92 children diagnosed with pneumonia between January 2021 and July 2022.

Genomic analysis of Zhou8425B, a key founder parent, reveals its genetic contributions to elite agronomic traits in wheat breeding.

High-quality genome information is essential for efficiently deciphering and improving crop traits. Here we report a highly contiguous and accurate hexaploid genome assembly for the key wheat breeding parent Zhou8425B, an elite 1BL/1RS translocation line with durable adult plant resistance (APR) against yellow rust (YR) disease. By integrating HiFi and Hi-C sequencing reads, a 14.

Microscopic Identification, Phytochemical Analysis, and Study of Antioxidant Properties of Branches, Leaves, and Fruits of Kazakh Medicine .

, a deciduous shrub from the Adoxaceae family, is a traditional Kazakh medicine used in Xinjiang, China. Its branches, leaves, and fruits are used to treat fractures, rheumatoid arthritis, and nephritis. To advance research on , we conducted studies on its microscopic identification, chemical composition, and biological activity.

A new spider species of the species group (Araneae, Pholcidae) from Hebei Province, northern China.

Background: The species group currently contains 47 species. It is mainly distributed in central and southern China, as well as northern Thailand.

New Information: Yao, sp.

Severe pneumonia caused by combined with infection: a case report.

is an obligate aerobic, Gram-negative bacillus belonging to the family of Weeksellacease. In recent years, there has been a gradual increase in related infections, especially in chronically hospitalized, immunocompromised populations that often develop severe pneumonia. Severe pneumonia is one of the common critical illnesses.

Two new species of Sarothrogammarus (Crustacea, Amphipoda) from Swat Valley, Pakistan.

Two new species of the genus Sarothrogammarus Martynov, 1935 are described and illustrated from Pakistan. Sarothrogammarus miandamensis sp. nov.

Accelerated pace of frailty in patients with schizophrenia.

Background: Schizophrenia is associated with an increased risk of mortality and physical comorbidities, indicating a potentially accelerated frailty process in affected individuals. This study aimed to test association between schizophrenia and frailty using the frailty index based on laboratory markers (FI-Lab).

Methods: A total of 600 patients with schizophrenia and 518 healthy controls, aged between 20 and 69 years were included in the present study.

Retinal structure guidance-and-adaption network for early Parkinson's disease recognition based on OCT images.

Parkinson's disease (PD) is a leading neurodegenerative disease globally. Precise and objective PD diagnosis is significant for early intervention and treatment. Recent studies have shown significant correlations between retinal structure information and PD based on optical coherence tomography (OCT) images, providing another potential means for early PD recognition.

Biomaterials' enhancement of immunotherapy for breast cancer by targeting functional cells in the tumor micro-environment.

Immunotherapy for breast cancer is now being considered clinically, and more recently, the number of investigations aimed specifically at nano-biomaterials-assisted immunotherapy for breast cancer treatment is growing. Alterations of the breast cancer micro-environment can play a critical role in anti-tumor immunity and cancer development, progression and metastasis. The improvement and rearrangement of tumor micro-environment (TME) may enhance the permeability of anti-tumor drugs.

H1N1 swine influenza viruses upregulate NEU1 expression through histone H3 acetylation regulated by HDAC2.

Mammalian membrane sialic acid is the key receptor for influenza virus. Sialidases, the main type of enzyme that can hydrolyze membrane sialic acids in mammalian cells, have the potential to affect the invasion process of influenza viruses, including H1N1. For the first time, this study focused on the regulation mechanism of sialidase NEU1 expression, and revealed that swine-origin influenza (H1N1) virus infection can promote NEU1 expression through histone H3 acetylation, which is regulated by HDAC2 in host cells.

Research progress of natural products targeting tumor-associated macrophages in antitumor immunity: A review.

As an important innate immune cell in the body, macrophages have a strong ability to phagocytic tumor cells and maintain the innate immune response. Tumor-associated macrophages play a more prominent role in regulating tumor immunity and are currently an important target of antitumor immunity. As a new type of antitumor therapy, tumor immunotherapy has great potential, combined chemotherapy, targeting and other therapeutic means can significantly enhance the antitumor therapy effect.

The Efficacy Research of Prophylactic PEG-rhG-CSF in Preventing Neutropenia in Early-Stage Breast Cancer Patients Treated With Docetaxel-Based Chemotherapy: A Retrospective Analysis.

Purpose: Docetaxel-based chemotherapy regimens (DBRs) are commonly used in the treatment of early-stage breast cancer (EBC). The prophylactic use of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) has been shown to reduce the incidence of neutropenia induced by DBRs. However, the clinical usage of PEG-rhG-CSF in EBC patients undergoing DBRs in China remains unclear.

Preparation of ortho-hydroxyl/carboxyl dual-functionalized hypercrosslinked polymers for highly efficient enrichment of nitrosamines with broad polarity prior to gas chromatography-mass spectrometry analysis.

N-nitrosamines (NAs) are highly carcinogenic substances commonly detected in food. They demonstrate a broad spectrum of polarity, posing a challenge in finding a suitable adsorbent capable of simultaneously adsorbing and enriching both polar and nonpolar NAs with high extraction recoveries. The present study involves the synthesis of a series of carboxyl functionalized hypercrosslinked polymers, followed by a comparative evaluation of their adsorption performance towards NAs.