Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque ().

The northern pig-tailed macaques (NPMs) lack TRIM5α, an antiviral restriction factor, and instead have TRIM5-CypA. In our previous study, we demonstrated that HIV-1 successfully infected NPMs and formed a long-term viral reservoir . However, the HIV-1-infected NPMs showed relatively high viremia in the first 6 weeks of infection, which declined thereafter suggesting that HIV-1 infection in these animals was only partly permissive.

Stable isotope labelling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Edwardsiella tarda ATCC 15947 under prolonged cold stress.

Edwardsiella tarda poses a threat to human health and has resulted in enormous economic losses in aquaculture. Low temperatures are usually applied to contain the growth of this microorganism. In this study, stable isotope labelling by amino acids in cell culture (SILAC) was used to conduct comparative proteomic quantitation of E.

Feasibility Evaluation of Preparing Asphalt Mixture with Low-Grade Aggregate, Rubber Asphalt and Desulphurization Gypsum Residues.

Road construction consumes great amounts of high-grade natural resources. Using low-grade natural rocks or some solid wastes as substitute materials is a hot topic. Considering this, the feasibility of using low-grade granite aggregate, solid waste-based filler (desulphurization gypsum residues, DGR) and binder (waste tire rubber modified asphalt, RMA) simultaneously in asphalt mixtures has been fully investigated in this research.

A Dedicated 36-Channel Receive Array for Fetal MRI at 3T.

Due to a lack of fetal imaging coils, the standard commercial abdominal coil is often used for fetal imaging, the performance of which is limited by its insufficient coverage, element number, and Signal-to-noise ratio (SNR). In this paper, a dedicated 36-channel coil array, of which size can best fit the body sizes of pregnancy gestation from 20 to 37+ weeks, was designed for fetal imaging at 3T. SNR with full phase encoding and G-factor denoted as noise amplification for parallel imaging were quantitatively evaluated by phantom studies.

CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS.

Chronic immune activation and systemic inflammation are underlying causes of acquired immunodeficiency syndrome (AIDS). Products of virus replication and microbial translocation, co-infection or opportunistic pathogens, and danger-associated molecular patterns have been reported to contribute to chronic immune activation and inflammation in human immunodeficiency virus type-1/simian immunodeficiency virus (HIV-1/SIV) infection or other disease. To develop new strategies and therapies for HIV-1/AIDS, we tested if the CD24 and Fc fusion protein (CD24Fc), which interacts with danger-associated molecular patterns and sialic acid binding Ig-like lectin to attenuate inflammation, can protect Chinese rhesus macaques (ChRMs) with SIV infection.

Electromagnetic Field and Radio Frequency Circuit Co-Simulation for Magnetic Resonance Imaging Dual-Tuned Radio Frequency Coils.

Electromagnetic (EM) field simulation plays a key role in the design of magnetic resonance imaging radio frequency (RF) coils. However, the values of the components in tuning and matching circuits often need to be iterated repeatedly in the conventional simulation method in order to achieve optimal scattering parameters. This leads to a time-consuming optimization to tune and match RF coils, particularly dual-tuned coils that are comprised of multiple lumped elements.

In-situ Cutting of Graphene into Short Nanoribbons with Applications to Ni-Zn Batteries.

Rechargeable Ni-Zn batteries, with high safety, low cost and nontoxicity, can be expected to compete with lithium-ion batteries for market share. However, the issue of dissolution of zinc electrode largely limit the battery cycle life and remains unsolved. We designed a kind of graphene-ZnO hybrid electrode in which in-situ cutting of graphene into short nanoribbons can effectively anchor plenty of zinc atoms onto the surface of graphene.

Ag/MnO₂ Nanorod as Electrode Material for High-Performance Electrochemical Supercapacitors.

A one-dimensional hierarchical Ag nanoparticle (AgNP)/MnO2 nanorod (MND) nanocomposite was synthesized by combining a simple solvothermal method and a facile reduction approach in situ. Owing to its high electrical conductivity, the resulting AgNP/MND nanocomposite displayed a high specific capacitance of 314 F g-1 at a current density of 2 A g-1, which was much higher than that of pure MNDs (178 F g-1). Resistances of the electrolyte (Rs) and charge transportation (Rct) of the nanocomposite were much lower than that of pure MNDs.

Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats.

This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress.

Mitophagy regulates macrophage phenotype in diabetic nephropathy rats.

Imbalance of M1/M2 macrophages phenotype activation is a key point in diabetic nephropathy (DN). Macrophages mainly exhibit M1 phenotype, which contributes to the inflammation and fibrosis in DN. Studies indicate that autophage plays an important role in M1/M2 activation.

HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo.

Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-1 will contribute to develop effective strategies for eradicating infections. Here, we inoculated 4 northern pig-tailed macaques (NPM) with the HIV-1 strain HIV-1 and monitored the infection for approximately 3years (150weeks).

Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α-ROS-p38MAPK pathway.

Macrophage infiltration has been linked to the pathogenesis of diabetic nephropathy (DN). However, how infiltrating macrophages affect the progression of DN is unknown. Although infiltrating macrophages produce pro-inflammatory mediators and induce apoptosis in a variety of target cells, there are no studies in podocytes.

[Effect of microRNA-155 on inflammatory response and lipid uptake of macrophages and its mechanism].

Objective To investigate the effect of microRNA-155 on inflammatory response and lipid uptake of macrophages after the cells are stimulated by ox-LDL and its potential mechanism. Methods Macrophage RAW264.7 cells were treated with 0, 25, 50 and 100 μg/mL ox-LDL for 24 hours or with 50 μg/mL ox-LDL for 0, 6, 12, 24 hours.

Proteomic Analysis of Vibrio parahaemolyticus Under Cold Stress.

Vibrio parahaemolyticus is a kind of food-borne pathogenic bacterium, which can seriously infect food, especially seafood causing gastroenteritis and other disease. We studied the global proteome responses of V. parahaemolyticus under cold stress by nano-liquid chromatography-tandem mass spectrometry to improve the present understanding of V.

Thermal stability and thermal conductivity of phosphorene in phosphorene/graphene van der Waals heterostructures.

Phosphorene, a new two-dimensional (2D) semiconducting material, has attracted tremendous attention recently. However, its structural instability under ambient conditions poses a great challenge to its practical applications. A possible solution for this problem is to encapsulate phosphorene with more stable 2D materials, such as graphene, forming van der Waals heterostructures.

Design of catheter radio frequency coils using coaxial transmission line resonators for interventional neurovascular MR imaging.

Background: It is technically challenging to design compact yet sensitive miniature catheter radio frequency (RF) coils for endovascular interventional MR imaging.

Methods: In this work, a new design method for catheter RF coils is proposed based on the coaxial transmission line resonator (TLR) technique. Due to its distributed circuit, the TLR catheter coil does not need any lumped capacitors to support its resonance, which simplifies the practical design and construction and provides a straightforward technique for designing miniature catheter-mounted imaging coils that are appropriate for interventional neurovascular procedures.

Sensitivity enhancement of traveling wave MRI using free local resonators: an experimental demonstration.

Background: Traveling wave MR uses the far fields in signal excitation and reception, therefore its acquisition efficiency is low in contrast to the conventional near field magnetic resonance (MR). Here we show a simple and efficient method based on the local resonator to improving sensitivity of traveling wave MR technique. The proposed method utilizes a standalone or free local resonator to amplify the radio frequency magnetic fields in the interested target.

Anomalous gray matter structural networks in recent onset post-traumatic stress disorder.

Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25).

Design of a Fatigue Detection System for High-Speed Trains Based on Driver Vigilance Using a Wireless Wearable EEG.

The vigilance of the driver is important for railway safety, despite not being included in the safety management system (SMS) for high-speed train safety. In this paper, a novel fatigue detection system for high-speed train safety based on monitoring train driver vigilance using a wireless wearable electroencephalograph (EEG) is presented. This system is designed to detect whether the driver is drowsiness.

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.

The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection.

Improved traveling-wave efficiency in 7T human MRI using passive local loop and dipole arrays.

Traveling-wave MRI, which uses relatively small and simple RF antennae, has robust matching performance and capability for large field-of-view (FOV) imaging. However, the power efficiency of traveling-wave MRI is much lower than conventional methods, which limits its application. One simple approach to improve the power efficiency is to place passive resonators around the subject being imaged.

Nonmonotonic Diameter Dependence of Thermal Conductivity of Extremely Thin Si Nanowires: Competition between Hydrodynamic Phonon Flow and Boundary Scattering.

By carefully and systematically performing Green-Kubo equilibrium molecular dynamics simulations, we report that the thermal conductivity (κ) of Si nanowires (NWs) does not diverge but converges and increases steeply when NW diameter (D) becomes extremely small (dκ/dD < 0), a long debate of one-dimensional heat conduction in history. The κ of the thinnest possible Si NWs reaches a superhigh level that is as large as more than 1 order of magnitude higher than its bulk counterpart. The abnormality is explained in terms of the dominant normal (N) process (energy and momentum conservation) of low frequency acoustic phonons that induces hydrodynamic phonon flow in the Si NWs without being scattered.

First-principles study of thermal transport in nitrogenated holey graphene.

Nitrogenated holey graphene (NHG), a new two-dimensional graphene variant with a large fundamental direct band gap, has recently been successfully synthesized via a simple wet-chemical reaction. Motivated by its unique geometry and novel properties, we investigated the phonon transport properties of the material by combining first-principle calculations and the phonon Boltzmann transport equation. The lattice thermal conductivity of NHG at room temperature is predicted to be about 82.

A 32-channel coil system for MR vessel wall imaging of intracranial and extracranial arteries at 3T.

Purpose: To develop a RF coil system for joint imaging of intracranial and extracranial arterial vessel wall at 3T.

Materials And Method: The coil system consists of a 24-channel head coil combined with an 8-channel carotid coil. It is compared with a standard coil configuration (12-channel head coil+4-channel neck coil+8-channel carotid coil) for SNR and g-factors in phantoms and healthy volunteers.