Surgical outcomes of aortic valve replacement in children with ross and ozaki procedure.

Objectives: To evaluate the midterm outcomes of the Ross and Ozaki procedures as alternatives to mechanical valve replacement in children with aortic valve disease.

Methods: All patients undergoing the Ross or Ozaki procedure between January 2017 and December 2023 were included. Primary outcomes were moderate or greater aortic valve stenosis (AS) or aortic regurgitation (AR) after surgery.

Metabolic regulation of amino acids provides an important basis for individualized nutritional therapy for patients with gastric cancer during the perioperative period.

Background: Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cancer cell metabolism, are implicated in the progression and response to treatment.

Methods: This study aimed to investigate the dynamics of plasma AA levels in gastric cancer patients preoperatively, postoperatively, and following nutritional intervention, comparing them to healthy controls.

Transcriptome Analysis Reveals the Molecular Mechanism of with Different Adhesion Abilities on Decay.

This study aimed to investigate the molecular mechanism of with varying adhesion capabilities to 's intestinal mucus influence the spoilage potential of . Sodium chloride(NaCl) was used as an environmental factor to regulate ' adhesion ability. After being exposed to 3.

Efficacy and safety of triplet regimen capecitabine, oxaliplatin, and irinotecan (XELOXIRI) as first-line chemotherapy for advanced pancreatic cancer.

Background: The 5-fuorouracil, oxaliplatin and irinotecan (FOLFOXIRI) regimen is the standard first-line treatment for advanced pancreatic cancer (APC). Capecitabine, an oral prodrug of 5-fluorouracil, offers a more convenient and potentially safer alternative. We evaluated the efficacy and safety of the XELOXIRI regimen (capecitabine, oxaliplatin, irinotecan) in Chinese patients with APC.

Investigating Causal Links Between Gut Microbiota and Neurological Disorders via Genome-Wide Association Studies.

Many reports have highlighted the involvement of the gut microbiome in the occurrence, progression, and outcomes of neurological disorders. However, current reports are somewhat chaotic, especially concerning whether the gut microbiota has a causal effect on various neurological diseases. Furthermore, whether there is a common mechanism involving gut microbial communities in these neurological disorders has not to be revealed.

Mechanisms and roles of hydroxychloroquine in pregnancy in rheumatic diseases.

Introduction: Hydroxychloroquine (HCQ), originally an antimalarial drug, is currently used to treat multiple disorders, especially rheumatic diseases. Given its good efficacy and safety, HCQ is widely administered in pregnant patients. However, the safety profile of HCQ during pregnancy remains controversial due to limited research.

Differential transcriptome profiling of spp. influenced by the species divergence factors.

To reveal the differences in transcript levels of spp. from different species and hosts and their impacts on phylogenetic relationships, we focus on 27 strains from four species (, , and ) and three hosts (, and ) to conduct the transcriptome sequencing using Illumina high-throughput sequencing technology. Gene expression differences between strains from different species and hosts are analyzed, and the results of phylogenetic analysis at the transcriptome and genome levels are compared.

In silico λ-dynamics predicts protein binding specificities to modified RNAs.

RNA modifications shape gene expression through a variety of chemical changes to canonical RNA bases. Although numbering in the hundreds, only a few RNA modifications are well characterized, in part due to the absence of methods to identify modification sites. Antibodies remain a common tool to identify modified RNA and infer modification sites through straightforward applications.

Computational evaluation of the biomechanical effects of position changes in the femoral neck system on Pauwels type III femoral neck fractures: an in silico study.

Introduction: Despite the biomechanical advantages of the Femoral Neck System (FNS), improvements in postoperative complication rates have not been significant. This study evaluated the effects of different FNS positions on the biomechanical stability of Pauwels type III femoral neck fractures (FNFs) using finite element analysis (FEA).

Methods: Pauwels type III FNF models fixed with different FNS positions were constructed using various bolt lengths, bolt positions, and axis-bolt angles.

Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration.

Nucleus pulposus (NP) tissue engineering brings new hope in the repair of intervertebral disc degeneration (IVDD). IVDD is often accompanied by multiscale changes in the mechanical microenvironment, including the changes of mechanical property of collagen fibril, NP tissue, and mechanical instability of spine. In this study, a multiscale mechanically-adapted strategy is proposed to promote NP repair.

Acupuncture alleviates neuro-inflammatory injury in rats with cognitive impairment induced by Parkinson's disease based on cGAS-STING signaling pathway.

Objectives: To observe the effect of acupuncture on neuro-inflammation in rats with cognitive impairment induced by Parkinson's disease (PD) based on the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway.

Methods: SD rats were randomly grouped into sham operation, model, acupuncture, acupuncture+empty and acupuncture+cGAS over-expression groups, with 12 rats in each group. The PD model was established by injecting 6-hydroxydopamine (6-OHDA, 8 μg/rat) into the substantia nigra pars compacta of the left midbrain (AP:-5.

ITGA8 deficiency in hepatic stellate cells attenuates CCl-Induced liver fibrosis via suppression of COL11A1.

Background And Objective: Liver fibrosis is a pathological process driven by chronic liver injury, characterized by excessive extracellular matrix (ECM) deposition due to hepatic stellate cell (HSC) activation. Integrins are critical regulators of ECM remodeling and HSC activation, yet the role of integrin α8(ITGA8) in liver fibrosis remains unclear. This study aims to investigate the function and underlying mechanisms of HSC-derived ITGA8 in liver fibrosis and evaluate the therapeutic potential of ITGA8-targeted intervention.

Construction of Self-healing Active Centers over Amorphous NiFe(OH) Nanosheets for Enhanced Oxygen Evolution Performance.

Developing efficient nickel-iron-based electrocatalysts for the oxygen evolution reaction (OER) still remains a challenge for long-term application in water electrolysis. Herein, amorphous NiFe hydroxide nanosheets with self-healing active centers supported on stainless steel mesh (-NiFe(OH)/SSM) are fabricated using a simple electrochemical deposition strategy. Raman evidence shows that the amorphous structure of -NiFe(OH)/SSM exhibits strong self-healing ability, efficiently promoting the rapid interconversion between the γ-NiOOH intermediate and Ni-based hydroxides during electrocatalysis.

Four new species of (Pichiales, Pichiaceae) isolated from China.

The genus belonging to the family Pichiaceae is widely distributed worldwide and has garnered significant attention due to its importance in various industries and its potential role in human infections. During our investigation of yeast diversity in China, several strains representing undescribed taxa were isolated from forests in Hainan province, Hubei province, Beijing city and a mudflat in Guangdong province. Based on phylogenetic analyses of the internal transcribed spacer (ITS) region and the D1/D2 domain of the large subunit (LSU) rRNA, these strains were identified as four new species: (holotype strain CGMCC 2.

Differences in Fibroinflammatory Activity Shown on Ga-FAPI-04 and F-FDG PET/CT in the Two Subtypes of IgG4-Related Disease.

IgG4-related disease (IgG4-RD) is a highly heterogeneous autoimmune disease. Recently, 2 subtypes of IgG4-RD, proliferative and fibrotic, were defined according to patients' clinicopathologic characteristics. The purpose of this study was to determine the difference in fibroinflammatory activity shown on Ga-FAPI-04 and F-FDG PET/CT in the proliferative and fibrotic IgG4-RD subtypes.

Study on the Differentiation of Infiltrating Breast Cancer Molecular Subtypes Based on Ultrasound Radiomics.

Objective: To establish and validate a 2-dimensional ultrasound (US) radiomics model for the noninvasive preoperative differentiation of various molecular subtypes of infiltrating breast cancer (IBC).

Methods: A retrospective analysis of 210 female patients diagnosed with IBC through surgical operation or needle biopsy pathology at our hospital between May 2019 and February 2024 was conducted. Relevant data were collected to establish predictive models for different molecular subtypes of IBC.

Distributions and partitioning of airborne Per- and Polyfluoroalkyl Substances (PFAS) in urban atmosphere of Northern New Jersey.

This study collected gas-phase and particulate samples, wet deposition, and total deposition from the urban atmosphere in Northern New Jersey to determine the atmospheric characteristics of airborne ionic Per- and Polyfluoroalkyl Substances (PFAS). The results showed higher PFAS concentrations in the gas phase (197.7 ± 47.

The use of gamified interventions to enhance social interaction and communication among people with autism spectrum disorder: A systematic review and meta-analysis.

Background: Traditional gamified interventions and serious games have been widely employed by therapists and researchers working with people with autism spectrum disorder. Recent studies have also indicated a trend towards technology-based gamification for training behavioral and social skills in autistic people. Nevertheless, the effectiveness of these gamified interventions in enhancing social interaction and communication outcomes among autistic people remains unclear.

Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis.

Background: Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear.

Aim: This study aimed to evaluate the association between individual adipose parameter and mortality in patients with cirrhosis using the meta-analysis method.

Enhanced Blood Vessel Visualization and Accelerated Image Acquisition Using Spiral MRA in Moyamoya Disease: A Comparative Study with Cartesian MRA.

Objectives: To compare the blood vessel visualization with spiral MRA (MRAspiral) and compressed SENSE accelerated Cartesian MRA (MRACS) in moyamoya disease (MMD) patients, with digital subtraction angiography (DSA) as the reference standard.

Methods: We prospectively collected MRAspiral with different acquisition windows (τ = 4, 6, 10 ms), MRACS and DSA in MMD patients. Contrast-to-noise ratio (CNR) was measured in the M1, M2, M3, and M4 segments of the middle cerebral artery (MCA) for each MRA sequence.

Microenvironment-Regulated Hydrogels Prepared with a Brand-New Small Molecule Cross-Linker for Stepwise Treatment of Myocardial Infarction.

Despite the development of many injectable hydrogels intended for the repair of myocardial infarction (MI), their effectiveness is often compromised because they target merely one or two phases of MI's pathological progression. Here, a multifunctional hydrogel delivery platform is prepared with a brand-new small molecule cross-linker for stepwise treatment of MI. The synthesis and reporting of a novel small-molecule phenylboronic acid cross-linker ((N(BA))) with a precise molecular structure is conducted for the first time, and it is successfully utilized with polyvinyl alcohol (PVA) dopamine to prepare a hydrogel with infarct microenvironmental responsiveness and anti-oxidant.

Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency.

The development of stable and efficient drug delivery systems is essential for advancing therapeutic applications. Here, we present an innovative approach using a mirror-image RNA (l-RNA) nanostructure to enhance the biostability and drug delivery efficiency. We engineered an l-RNA three-way junction structure conjugated with both small interfering RNA (siRNA) targeting MCL1 and the chemotherapeutic agent doxorubicin for targeted and synergistic drug delivery.

sp. nov., a novel ascomycetous yeast species from Xinghuacun Fenjiu old workshop, Shanxi province of China.

Four yeast strains belonging to the ascomycetous yeast genus were isolated from the mixture of remnants of steamed sorghum, Daqu powder and the fermented grain that fell off during transportation on the ground in the workshop which were collected in Xinghuacun Fenjiu old workshop, Shanxi province, PR China. We propose the name sp. nov.

Crystal- and Pore-Size Dependent Iodine Adsorption Properties in MOFs.

Metal-organic frameworks (MOFs) with unique pore architectures and electron-rich sites exhibit an unprecedented iodine capture property. In this contribution, the crystal-size and pore-size-dependent iodine adsorption behavior in MOFs ranging in crystal size from nanometers to micrometers with mesoporous and microporous structures is reported. Nano-sized MOFs have much higher iodine adsorption capacities and rates than Micro-sized MOFs.

Computed tomography-based delta-radiomics analysis for preoperative prediction of ISUP pathological nuclear grading in clear cell renal cell carcinoma.

Background: Nuclear grading of clear cell renal cell carcinoma (ccRCC) plays a crucial role in diagnosing and managing the disease.

Objective: To develop and validate a CT-based Delta-Radiomics model for preoperative assessment of nuclear grading in renal clear cell carcinoma.

Materials And Methods: This retrospective analysis included surgical cases of 146 ccRCC patients from two medical centers from December 2018 to December 2023, with 117 patients from Hospital and 29 from the *Hospital Affiliated to University of **.