Chitosan/polyvinyl alcohol-based magnetic hydrogel microspheres with controlled retention and regulated drug release for intravesical instillation.

As a clinically effective treatment for bladder cancer (BC), intravesical instillation still suffers from the debilitating efficacy triggered by frequent urination. Herein, the magnetic hydrogel microspheres (DOX-mMSs) with the incorporation of magnetic nanoparticles (MNPs) and doxorubicin (DOX) into polyvinyl alcohol (PVA)/chitosan (CS) are developed for intravesical instillation. The magnetic force initiated by the applied magnetic field (AMF) enables the long-term retention of DOX-mMSs in the bladder, and the convenient injection and excretion from the bladder can be accomplished in virtue of the micron size of the DOX-mMSs.

Fluoroquinolone antibiotics trigger selective oxidation in the trace-Cu(II)/peroxydisulfate system: The synergistic effect of dual reactive sites in chemical structure.

Research on transition metal-triggered advanced oxidation processes (TM-AOPs) has primarily focused on the regulation of catalysts and oxidants, but the alternative route that involves utilizing pollutant-derived electrons to enhance TM-AOPs has been largely overlooked. This study presents a case of selective degradation using fluoroquinolone antibiotics, with ofloxacin (OFX) selected as the model pollutant. Under the presence of PDS and trace Cu(II) (10 μM or 0.

Life-history traits trade-off in gecko (Gekko japonicus) under the influence of climate warming and spirotetramat: Different adaptations to stressors in female and male.

Global warming and rising surface temperatures are adversely affecting organisms. As the use of pesticides increases, concerns about their impacts on non-target organisms are growing. However, climate warming and pesticides may interact to produce combined effects on organisms.

Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates.

Idiopathic intracranial hypertension (IIH) is a disease characterized by increased intracranial pressure (ICP) without identifiable secondary causes. While the increased ICP is a critical diagnostic feature, the underlying pathophysiological mechanisms remain unclear. Previous theories have suggested cerebrospinal fluid (CSF) overproduction, impaired reabsorption, or circulatory obstruction as potential causes.

Inflammatory Signaling Induces Mitochondrial Dysfunction and Neuronal Death in Traumatic Brain Injury via Downregulation of OXPHOS Genes.

Traumatic brain injury (TBI) is a major cause of neurological dysfunction and disability. This study aimed to investigate the transcriptomic changes and the functional consequences in TBI, focusing on the interplay between inflammation and mitochondrial impairment. Brain tissue samples from TBI patients and healthy controls were subjected to RNA-sequencing analysis.

Erlotinib-Gold(I) Complex Induces Leukemia Cell DC Differentiation and Remodels the Immunosuppressive Microenvironment.

Inducing differentiation of leukemia cells into dendritic cells (DC) is pivotal to reshaping the immunosuppressive microenvironment. Here, we report the synthesis of , an erlotinib-gold(I) complex, which directly prompts the differentiation of acute myeloid leukemia (AML) cells into DCs. A patient-derived xenograft (PDX) model underscores the potent anti-AML activity of .

Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1.

The Vpx protein encoded by HIV-2/simian immunodeficiency virus (SIV) can antagonize the restriction of the host intrinsic restriction factor, SAMHD1, in nondividing cells by promoting its polyubiquitination and subsequent degradation, thereby facilitating viral replication and immune evasion. However, the role of deubiquitinating enzymes (DUBs) in the dynamics of virus and host remains poorly understood. Here, we demonstrate that DUB USP37 significantly reverses the Vpx-mediated degradation of SAMHD1 in various HIV-2/SIV subtypes by interacting with SAMHD1 and removing its ubiquitin chains.

Nanoporous High Entropy Alloy Al-Pt-Pd-Ru as an Efficient Catalyst for One-Pot Reductive Amination of Nitroarenes.

High entropy alloys (HEAs) are promising heterocatalysts because of their unique physicochemical properties, but research on HEA-catalyzed tandem reactions is lacking. Moreover, limited research on HEAs for molecular transformation has hindered their development. Herein, an unsupported nanoporous HEA Al-Pt-Pd-Ru (HEANPore) prepared using a top-down dealloying method is reported.

Intramolecular Hydrogen Bonds Weaken Interaction Between Solvents and Small Organic Molecules Towards Superior Lithium-Organic Batteries.

The strong interaction between organic electrode materials (OEMs) and electrolyte components induces a high solubility tendency of OEMs, thus hindering the practical application of lithium-organic batteries. Herein, we propose an efficient strategy for intramolecular hydrogen bonds (HBs) to redistribute the charge of OEMs to weaken the interaction with electrolyte components, thereby suppressing their dissolution. For the designed 2,2',2''-(2,4,6-trihydroxybenzene-1,3,5-triyl) tris (1H-naphtho[2,3-d]imidazole-4,9-dione) (TPNQ) molecule, the intramolecular HBs (O-H⋅⋅⋅N and N-H⋅⋅⋅O) reduce the charge density of active sites and alter the charge distribution on the molecular skeleton.

Work Reward Moderates the Association Between Work Effect and Workplace Violence Among Medical Staff in China.

Purpose: Workplace violence (WPV) against healthcare workers is a significant public health issue in China and globally. Although the effort-reward imbalance theory claimed that work rewards may moderate the relationship between work effort and WPV, the quantitative evidence is limited. This study aimed to examine if work reward could moderate the associations between work effort and WPV against medical staff based on the effort-reward imbalance theory.

The impact of flywheel resistance squat training on lower limb strength in female college basketball players.

Objective: This study compared the effects of Flywheel Resistance Squat Training (FRST) vs. Traditional Resistance Squat Training (TRST) on lower body strength in female collegiate basketball players.

Methods: Nineteen participants were randomly assigned to either the FRST group (n = 9) or the TRST group (n = 10) through a random number draw.

Shedding light on negative cultures in osteoarticular infections: leveraging mNGS to unravel risk factors and microbial profiles.

Background: The objective of this study is to utilize metagenomic next-generation sequencing (mNGS) to analyze the risk factors causing negative microbial cultures, comprehensively delineate the microbial profiles neglected by traditional cultures, and optimize the pathogenetic diagnostic procedure accordingly.

Research Design And Methods: We enrolled 341 patients diagnosed with OI at our center between 2016 and 2022, and gathered data including age, gender, clinical diagnosis, duration of antibiotic use prior to sampling, microbial culture results, and mNGS results for these patients. According to microbial detection results, risk factors for negative microbial culture and mNGS results were investigated through univariate and multivariate analyses, and the microbial profile in cases with negative microbial cultures was summarized in conjunction with mNGS results.

Enhanced irradiation-resistance in NbMoTaW refractory high-entropy alloy via rhenium addition.

The He irradiation-induced mechanical and microstructural evolutions were studied in NbMoTaW (at.%) and NbMoTaWRe (at.%) refractory high-entropy alloys (RHEAs) films, respectively.

Cerebral vascular malformations: pathogenesis and therapy.

Cerebral vascular malformations (CVMs), particularly cerebral cavernous malformations and cerebral arteriovenous malformations, pose significant neurological challenges due to their complex etiologies and clinical implications. Traditionally viewed as congenital conditions with structural abnormalities, CVMs have been treated primarily through resection, embolization, and stereotactic radiosurgery. While these approaches offer some efficacy, they often pose risks to neurological integrity due to their invasive nature.

Overview of evidence-based research on acupuncture for stroke treatment using magnetic resonance imaging technology.

Background: Stroke is a neurological condition characterized by high rates of disability and mortality. Magnetic resonance imaging (MRI) is widely used to examine the mechanisms of acupuncture in stroke treatment.

Purpose: This review provides neuroimaging evidence for the efficacy of acupuncture in treating stroke using MRI.

A Mitochondria-Targeting and Peroxynitrite-Activatable Ratiometric Fluorescent Probe for Precise Tracking of Oxidative Stress-Induced Mitophagy.

Mitochondria are the energy factory of cells and can be easily damaged by reactive oxygen species (ROS) because of the frequent occurrence of oxidative stress. Abnormality in mitophagy is often associated with many diseases including inflammation, cancer, and aging. While previously developed fluorescent probes mainly focus on detecting just ROS or mitophagy, quite rare studies have endeavored to comprehensively capture the entire mitophagic process, encompassing both the production of ROS and the induction of mitophagy.

Prevalence of hypertension and its associated factors among healthcare workers in the Gaza Strip, Palestine: a cross-sectional study.

Background And Objectives: Hypertension (HTN) is one of the leading risk factors of cardiovascular diseases and accounts for substantial morbidity and mortality worldwide. We aimed to estimate the prevalence of HTN and its associated factors among healthcare workers (HCWs) at the Gaza Strip's governmental hospitals and primary healthcare centres (PHCs).

Design: Cross-sectional study.

[Pulmonary nodular lymphoid hyperplasia: a case report].

Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare pulmonary lymphoproliferative disease characterized by the absence of specific clinical and imaging features. Consequently, diagnosis relies heavily on postoperative pathological examination, which often leads to preoperative misdiagnosis. Here, we report an atypical case of PNLH in a 57-year-old female patient who was admitted to hospital after a pulmonary nodule was discovered during a routine physical examination two days earlier.

Targeting hyperactive mitochondria in activated HSCs and inhibition of liver fibrogenesis in mice using sorafenib complex micelles.

Liver fibrosis is a pathological condition marked by the excessive buildup of extracellular matrix primarily resulting from the transformation of quiescent hepatic stellate cells (HSCs) to myofibroblastic (MF) phenotype and their resultant over-expansion. Activated HSCs completely rely on their hyperactive mitochondria to supply the energy and biomass for their rapid proliferation and collagen secretion, so an intervention targeting their mitochondria can effectively restrict their pathological amplification and contribution to liver fibrosis. Here we tried sorafenib, a drug that plays anticancer roles by inducing the disruption and loss of mitochondrial functions, to reach an antifibrotic goal.