Nature-Inspired Approach: A Novel Rat Optimization Algorithm for Global Optimization.

This work presents a rat optimization algorithm (ROA), which simulates the social behavior of rats and is a new nature-inspired optimization technique. The ROA consists of three operators that simulate rats searching for prey, chasing and fighting prey, and jumping and hunting prey to deal with optimization issues. The Levy flight strategy is introduced into the ROA to keep the algorithm from running into issues with slow convergence and local optimums.

CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway.

Background: Acute pancreatitis (AP) is a prevalent and serious condition within the digestive system, with approximately 20 % to 30 % of cases advancing to severe acute pancreatitis (SAP). During the initial phases of SAP, macrophages are activated in response to the substantial amounts of acinar cell contents and damage-associated molecular patterns (DAMPs) resulting from acinar cell destruction. Subsequently, activated macrophages release a significant array of pro-inflammatory factors that exacerbate the progression of SAP.

Risk factors for pleural effusion in children with plastic bronchitis caused by pneumonia.

Objective: We aimed to investigate the clinical features of children with plastic bronchitis caused by pneumonia, and assess the risk factors for pleural effusion (PE) in plastic bronchitis.

Methods: A retrospective study was conducted on children with plastic bronchitis and hospitalized in Xiamen Children's Hospital from January 2017 to April 2023. Participants were categorized based on the presence of PE.

ECSIT: Biological function and involvement in diseases.

Evolutionary conserved signaling intermediate in Toll pathways (ECSIT), a multi-functional protein, was first identified as a cytosolic adaptor protein in Toll-like receptors (TLRs) signaling-mediated innate immune responses. In the past two decades, studies have expanded the understanding of ECSIT. Nevertheless, there are still large knowledge gaps due to the inadequate number of studies regarding ECSIT, especially an overall review of ECSIT is lacking.

Time-Synchronized Convergence Control for n-DOF Robotic Manipulators with System Uncertainties.

A time-synchronized (TS) convergence control method for robotic manipulators is proposed. Adversely to finite-time control, a notion of time-synchronization convergence is introduced based on the ratio persistence property, which can ensure that all system components converge simultaneously in a finite time. Firstly, a robust disturbance observer is constructed to be compatible with the time-synchronized control framework and precisely estimate system uncertainties.

Engineered moiré photonic and phononic superlattices.

Recent discoveries of Mott insulating and unconventional superconducting states in twisted bilayer graphene with moiré superlattices have not only reshaped the landscape of 'twistronics' but also sparked the rapidly growing fields of moiré photonic and phononic structures. These innovative moiré structures have opened new routes of exploration for classical wave physics, leading to intriguing phenomena and robust control of electromagnetic and mechanical waves. Drawing inspiration from the success of twisted bilayer graphene, this Perspective describes an overarching framework of the emerging moiré photonic and phononic structures that promise novel classical wave devices.

CGJO: a novel complex-valued encoding golden jackal optimization.

Golden jackal optimization (GJO) is inspired by mundane characteristics and collaborative hunting behaviour, which mimics foraging, trespassing and encompassing, and capturing prey to refresh a jackal's position. However, the GJO has several limitations, such as a slow convergence rate, low computational accuracy, premature convergence, poor solution efficiency, and weak exploration and exploitation. To enhance the global detection ability and solution accuracy, this paper proposes a novel complex-valued encoding golden jackal optimization (CGJO) to achieve function optimization and engineering design.

Variations in soil microbial communities in different saline soils under typical Populus spp. vegetation in alpine region of the Qaidam Basin, NW China.

Salinization is a severe threat to agriculture and the environment in many areas, and the same in Qaidam Basin, Qinghai Province, Northwestern China. Microorganisms have an important influence on regulating the biochemical cycles of ecosystems; however, systematic research exploring microbial diversity and interactions with saline-soil ecosystems' environmental variables remains scarce. Thus, 16 S rRNA high-throughput sequencing was performed in this paper to characterize microbial diversity under different levels of salinized soils: non-salinized (NS, 2.

Monolithically Structured van der Waals Materials for Volume-Polariton Refraction and Focusing.

Polaritons, hybrid light and matter waves, offer a platform for subwavelength on-chip light manipulation. Recent works on planar refraction and focusing of polaritons all rely on heterogeneous components with different refractive indices. A fundamental question, thus, arises whether it is possible to configure two-dimensional monolithic polariton lenses based on a single medium.

Hydrogenation of Covalent Organic Framework Induces Conjugated π Bonds and Electronic Topological Transition to Enhance Hydrogen Evolution Catalysis.

Recently, many topological materials have been discovered as promising electrocatalysts in chemical conversion processes and energy storage. However, it remains unclear how the topological electronic states specifically modulate the catalytic reaction. Here, the two-dimensional metal phthalocyanine-based covalent organic framework (MPc-COF) is studied by ab initio thermodynamic calculations to clearly reveal the promotional effect on the electrochemical hydrogen evolution reaction (HER) induced by topological gapless bands (TGBs).

Impact of Obesity on Hepatic Drug Clearance: What are the Influential Variables?

Drug clearance in obese subjects varies widely among different drugs and across subjects with different severity of obesity. This study investigates correlations between plasma clearance (CLp) and drug- and patient-related characteristics in obese subjects, and evaluates the systematic accuracy of common weight-based dosing methods. A physiologically-based pharmacokinetic (PBPK) modeling approach that uses recent information on obesity-related changes in physiology was used to simulate CLp for a normal-weight subject (body mass index [BMI] = 20) and subjects with various severities of obesity (BMI 25-60) for hypothetical hepatically cleared drugs with a wide range of properties.

Targeted inhibition of STAT3 (Tyr705) by xanthatin alleviates osteoarthritis progression through the NF-κB signaling pathway.

The transcription factor, signal transducer, and stimulator of transcription 3 (STAT3) is a potential target in osteoarthritis (OA) treatment. Although xanthatin (XA), a biologically active substance derived from Xanthium strumarium L, specifically inhibits STAT3 phosphorylation at Tyr705, the mechanism underlying its inhibitory effect on OA progression remains unclear. In this study, our objective was to explore the therapeutic effects exerted by XA on OA and the underlying molecular mechanisms.

Ultrafast magnetization enhancement via the dynamic spin-filter effect of type-II Weyl nodes in a kagome ferromagnet.

The magnetic type-II Weyl semimetal (MWSM) CoSnS has recently been found to host a variety of remarkable phenomena including surface Fermi-arcs, giant anomalous Hall effect, and negative flat band magnetism. However, the dynamic magnetic properties remain relatively unexplored. Here, we investigate the ultrafast spin dynamics of CoSnS crystal using time-resolved magneto-optical Kerr effect and reflectivity spectroscopies.

Study of the mutual coupling characteristics of the oxidation thermal effect and microstructural evolution of gas-containing coal.

Besides be affected by coal confining pressure, coal seams are also be affected by the surrounding pressure during mining. To understand the heat release characteristics and microstructural evolution of oxidization within coal under different gas pressures is of great significance. For this reason, a combination of theoretical research and test analysis was adopted, which includes differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and mercury intrusion method (MIP).

Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.

Metastasis causes most cancer-related deaths, and the role and mechanism of periostin (POSTN) in the metastasis of hepatocellular carcinoma (HCC) remain undiscovered. In this study, DEN and HTVi HCC models were performed in hepatic-specific Postn ablation and Postn knock-in mouse to reveal the role of POSTN in HCC metastasis. Furthermore, POSTN was positively correlated with circulating EPCs level and promoted EPC mobilization and tumour infiltration.

3,4-Dichlorophenylacetic acid acts as an auxin analog and induces beneficial effects in various crops.

Auxins and their analogs are widely used to promote root growth, flower and fruit development, and yield in crops. The action characteristics and application scope of various auxins are different. To overcome the limitations of existing auxins, expand the scope of applications, and reduce side effects, it is necessary to screen new auxin analogs.

Strain-Induced Topological Phase Transitions Covering the Indicator in Orthorhombic LiAuBi.

The symmetry indicator is widely used to classify topological materials hosting inversion symmetry. We find orthorhombic LiAuBi in space group is a topological insulator with under no strain via first-principles calculations. Due to small band gaps in the = 0 plane, the band inversions can be selectively induced by moderate external strains to realize phases covering all values of = 1, 2, 3, and 0.