Genetic and phenotypic analysis of 225 Chinese children with developmental delay and/or intellectual disability using whole-exome sequencing.

Developmental delay (DD), or intellectual disability (ID) is a very large group of early onset disorders that affects 1-2% of children worldwide, which have diverse genetic causes that should be identified. Genetic studies can elucidate the pathogenesis underlying DD/ID. In this study, whole-exome sequencing (WES) was performed on 225 Chinese DD/ID children (208 cases were sequenced as proband-parent trio) who were classified into seven phenotype subgroups.

A structured sentiment analysis dataset based on public comments from various domains.

A structured sentiment analysis dataset, derived from social media comments, is introduced in this paper. The dataset spans 22 diverse domains and comprises over 200,000 reviews, providing a rich resource for sentiment analysis tasks in the Chinese language context. Each comment within the dataset has been manually annotated with a sentiment label, either positive, negative, or neutral, and grouped by topic.

A Joint Extraction Model for Entity Relationships Based on Span and Cascaded Dual Decoding.

The entity-relationship joint extraction model plays a significant role in entity relationship extraction. The existing entity-relationship joint extraction model cannot effectively identify entity-relationship triples in overlapping relationships. This paper proposes a new joint entity-relationship extraction model based on the span and a cascaded dual decoding.

Nested Named Entity Recognition Based on Dual Stream Feature Complementation.

Named entity recognition is a basic task in natural language processing, and there is a large number of nested structures in named entities. Nested named entities become the basis for solving many tasks in NLP. A nested named entity recognition model based on dual-flow features complementary is proposed for obtaining efficient feature information after text coding.

Real-world 10-year retrospective study of the guidelines for diagnosis and treatment of primary liver cancer in China.

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide. Many regions across the world have issued various HCC diagnosis and treatment protocols to improve the diagnosis and targeted treatment of patients with HCC. However, real-world studies analysing the practice, application value, and existing problems of the China Liver Cancer (CNLC) staging system are scarce.

Building Fake Review Detection Model Based on Sentiment Intensity and PU Learning.

Fake review detection has the characteristics of huge stream data processing scale, unlimited data increment, dynamic change, and so on. However, the existing fake review detection methods mainly target limited and static review data. In addition, deceptive fake reviews have always been a difficult point in fake review detection due to their hidden and diverse characteristics.

Assessing health-related quality of life and health utilities in patients with chronic hepatitis B-related diseases in China: a cross-sectional study.

Objectives: The health-related quality of life (HRQoL) and utilities of patients with chronic hepatitis B (CHB) virus infection, including compensated cirrhosis (CC), decompensated cirrhosis (DC) and different stages of hepatocellular carcinoma (HCC), have not been well described in China. This study aimed to evaluate HRQoL and utilities and provide parameters for the economic evaluation of CHB-related diseases.

Methods: We conducted a multicentre cross-sectional and study to measure the HRQoL of patients with CHB, CC, DC and HCC using the Chinese short form (SF) 36 health survey V.

Incidence of novel coronavirus (2019-nCoV) infection among people under home quarantine in Shenzhen, China.

Background: Since the outbreak of 2019-nCoV in December, Chinese government has implemented various measures including travel bans, centralized treatments, and home quarantines to slowing the transmission across the country. In this study, we aimed to estimate the incidence of 2019-nCoV infection among people under home quarantine in Shenzhen, China.

Methods: We used a stratified multistage random sampling method to recruit participants and collected demographic information and laboratory results of people under home quarantine.

Distributed Reliable and Efficient Transmission Task Assignment for WSNs.

Task assignment is a crucial problem in wireless sensor networks (WSNs) that may affect the completion quality of sensing tasks. From the perspective of global optimization, a transmission-oriented reliable and energy-efficient task allocation (TRETA) is proposed, which is based on a comprehensive multi-level view of the network and an evaluation model for transmission in WSNs. To deliver better fault tolerance, TRETA dynamically adjusts in event-driven mode.

[Effect of afforestation modes on soil microbial community and nitrogen functional genes in Hippophae rhamnoides plantation].

The study aimed to assess the effect of different afforestation modes on microbial composition and nitrogen functional genes in soil. Soil samples from a pure Hippophae rhamnoides stand (SS) and three mixed stands, namely, H. rhamnoides and Pinus tabuliformis (SY), H.

Effect of monospecific and mixed sea-buckthorn (Hippophae rhamnoides) plantations on the structure and activity of soil microbial communities.

This study aims to evaluate the effect of different afforestation models on soil microbial composition in the Loess Plateau in China. In particular, we determined soil physicochemical properties, enzyme activities, and microbial community structures in the top 0 cm to 10 cm soil underneath a pure Hippophae rhamnoides (SS) stand and three mixed stands, namely, H. rhamnoides and Robinia pseucdoacacia (SC), H.

[The analyses of HIV-1 quasispecies in HIV-infected subjects by the application of single genome amplification assay].

Objective: To establish the single genome amplification (SGA) method and analyze the quasispecies in HIV-infected patients.

Methods: All 6 sample RNA acquired in 2010 in Shenzhen and genetic sequenced as overlap peaks were extracted and diluted to a single copy, nest-PCR after one step RT-PCR was employed to amplify HIV-1 genome, and then PCR products was purified and sequenced. Mega 4.

Rural villagers and urban residents exposure to poultry in China.

Patterns of poultry exposure in rural and urban areas in China have not been systematically evaluated and compared. The objective of our study is to investigate patterns in human exposure to poultry in rural and urban China. We conducted a two-stage household-based clustered survey on population exposure to live/sick/dead poultry in Xiuning and Shenzhen.

[Field epidemiological study on news reports that related to public health emergencies].

Objective: All news reports (NR) that were related to public health emergency (PHE) were collected from the Southern Metropolis Daily (SMD) to explore the characteristics of epidemiology in the fields.

Methods: Based on the theory of communication that including both case and text analysis, qualitative analysis on all the NR regarding PHE published in SMD from the years of 2008 to 2012, was carried out and input to database using the EpiData. Numbers of articles as indicators were compared to show the yearly change of different types of events.

[Field epidemiological study on a varicella outbreak among schoolchildren in Shenzhen].

Objective: Both epidemiologic characteristics and transmission mode of a varicella outbreak among schoolchildren in Shenzhen city were studied and related control measures were discussed.

Methods: Case definition was established. Case-finding and face-to-face investigation were conducted, followed by analysis on distributions of time, place and persons of the outbreak.

[A nitrite poisoning event associated with intentional chemical releases].

Objective: To compare the field epidemiological investigation and the criminal investigation on a nitrite poisoning event caused by deliberate contamination.

Methods: Cases were searched according to the definition of the disease. Information on the histories of onset and diet of all the cases and normal population on site, were investigated face to face.

[Decision tree and cost-benefit analysis on strategies related to preventing maternal-infantile transmission of hepatitis B virus infection].

Objective: To synthesize relevant data and to analyze the benefit-cost ratio on strategies related to preventing the maternal-infantile transmission of hepatitis B virus infection and to explore the optimal strategy.

Methods: A decision tree model was constructed according to the strategies of hepatitis B immunization and a Markov model was conducted to simulate the complex disease progress after HBV infection. Parameters in the models were drawn from meta-analysis and information was collected from field study and review of literature.

Direct economic burden of hepatitis B virus related diseases: evidence from Shandong, China.

Background: Although the expenses of liver cirrhosis are covered by a critical illness fund under the current health insurance program in China, the economic burden associated with hepatitis B virus (HBV) related diseases is not well addressed. In order to provide evidence to address the economic disease burden of HBV, we conducted a survey to investigate the direct economic burden of acute and chronic hepatitis B, cirrhosis and liver cancer caused by HBV-related disease.

Methods: From April 2010 to November 2010, we conducted a survey of inpatients with HBV-related diseases and who were hospitalized for seven or more days in one of the seven tertiary and six secondary hospitals in Shandong, China.

Epidemiological dynamics and phylogeography of influenza virus in southern China.

Background: Understanding the epidemiological dynamics of influenza virus is central to surveillance and vaccine strain selection. It has been suggested that tropical and subtropical regions represent the global source of influenza epidemics. However, our understanding of the epidemiological dynamics of influenza virus in these regions is limited by a relative lack of long-term data.

[Estimation on the intangible cost and influencing factors for patients with hepatitis B-related diseases].

Objective: To estimate the intangible cost and associated factors on patients with hepatitis B-related diseases, so as to explore the differences of the three elicitation techniques on the 'willingness to pay approach' (WTP).

Methods: Face-to-Face interviews were conducted to collect health economics-related information by trained investigators, using a structured questionnaire. WTP was employed to estimate the intangible cost while an open-ended question format, together with iterative bidding game and payment card were respectively used to elicit WTP for the hypothetical cure of hepatitis B-related diseases.

[Financial burden of hepatitis B-related diseases and factors influencing the costs in Shenzhen, China].

Objective: To investigate the direct, indirect and intangible costs due to hepatitis B-related diseases and to explore main factors associated with the costs in Shenzhen.

Methods: Cluster sampling for cases collected consecutively during the study period was administrated. Subjects were selected from eligible hepatitis B-related patients.

Knowledge, attitudes and practices (KAP) relating to avian influenza in urban and rural areas of China.

Background: Studies have revealed that visiting poultry markets and direct contact with sick or dead poultry are significant risk factors for H5N1 infection, the practices of which could possibly be influenced by people's knowledge, attitudes and practices (KAPs) associated with avian influenza (AI). To determine the KAPs associated with AI among the Chinese general population, a cross-sectional survey was conducted in China.

Methods: We used standardized, structured questionnaires distributed in both an urban area (Shenzhen, Guangdong Province; n = 1,826) and a rural area (Xiuning, Anhui Province; n = 2,572) using the probability proportional to size (PPS) sampling technique.