Nucleolar protein PEXF controls ribosomal RNA synthesis and pluripotency exit.

Maintenance and exit from pluripotency of embryonic stem cells (ESCs) are controlled by highly coordinated processes of protein synthesis and ribosome biogenesis (RiBi). ESCs are characterized by low rates of global protein synthesis and high levels of RiBi. Transient reduction of RiBi is a characteristic molecular event during the exit from pluripotency, of which the regulatory mechanism is unclear.

Clinical Features and Transition of Acute Hepatitis B Virus Infection.

Acute hepatitis B (AHB) is generally a self-limiting illness in adults and most patients achieve hepatitis B surface antigen (HBsAg) clearance within 6 months. We aimed to investigate the proportion and influencing factors of chronic outcome in adult AHB patients. A total of 126 consecutive AHB patients were included between January 2013 and October 2018.

Secular trends in motor abilities of Xinjiang children and adolescents aged 7-18 years from 1985 to 2019.

Objective: To assessment the secular trend in physical fitness of children and adolescents aged 7-18 years in Xinjiang from 1985 to 2019.

Method: The data are derived from test scores of Xinjiang Chinese children and adolescents aged 7-18 years by the China National Student Health Monitoring Centre National Student Physical Fitness Monitoring in 1985, 1991, 1995, 2000, 2005, 2010, 2014, and 2019. The physical fitness indicators included speed, cardiorespiratory fitness, muscular strength, power, and flexibility.

[A comorbidity survey of growth retardation and obesity in Chinese children aged 7-12 years and analysis of influencing factors].

Objectives: To investigate the changing trends and influencing factors for growth retardation-related obesity in Chinese children aged 7-12 years in 2010-2020, providing a basis for formulating physical health interventions for children.

Methods: The data of body height and body mass index were collected from 16 289 children aged 7-12 years in the China Family Panel Studies (CFPS) in 2010-2020, and the trends of growth retardation, obesity, and growth retardation-related obesity in 2010-2020 were analyzed and compared between different sexes and between urban and rural areas.

Results: From 2010 to 2020, the overall rates of growth retardation and growth retardation-related obesity among children aged 7-12 years in China showed a declining trend (<0.

A triple protein-based ELISA for differential detection of ASFV antibodies.

African swine fever (ASF) caused by the ASF virus (ASFV) is a severe and highly contagious viral disease that poses a significant threat to the global pig industry. As no vaccines or effective drugs are available to aid prevention and control, early detection is crucial. The emergence of the low-virulence ASFV strain not expressing CD2v/MGFs (ASFVΔCD2v/ΔMGFs) has been identified domestically and internationally and has even become an epidemic in China, resulting in a complex epidemic.

Risk of bleeding in pulmonary embolism patients concomitant with COVID-19 undergoing extended anticoagulation: A multicenter cohort study.

Introduction: The impact of Coronavirus disease 2019 (COVID-19) on clinical outcomes in pulmonary embolism (PE) patients receiving extended anticoagulation therapy is not fully understood. The study aimed to investigate the impact of the Omicron outbreak on patients with PE receiving extended anticoagulation therapy.

Materials And Methods: This prospective multicenter cohort study was conducted during the Omicron pandemic.

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI.

Purpose: To investigate the follicle microenvironments of women with premature ovarian insufficiency (POI), with normal ovarian reserve function, and who are older (age >40 years) and to identify potential therapeutic targets.

Patients And Methods: In total, 9 women who underwent in vitro fertilization(IVF) or intracytoplasmic sperm injection(ICSI) were included in this study. The first punctured follicle of each patient was used.

Thermal Transfer Printed Flexible and Wearable Bionic Skin with Bilayer Nanofiber for Comfortable Multimodal Health Management.

The advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real-time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications.

Chlorine Axial Coordination Activated Lanthanum Single Atoms for Efficient Oxygen Electroreduction with Maximum Utilization.

Currently, there are still obstacles to rationally designing the ligand fields to activate rare-earth (RE) elements with satisfactory intrinsic electrocatalytic reactivity. Herein, axial coordination strategies and nanostructure design are applied for the construction of La single atoms (La-Cl SAs/NHPC) with satisfactory oxygen reduction reaction (ORR) activity. The nontrivial LaNCl motifs configuration and the hierarchical porous carbon substrate that facilitates maximized metal atom utilization ensure high half-wave potential (0.

Clinical Outcome of Extended Curettage with Postoperative Denosumab Administration for the Treatment of Campanacci Grade III Giant Cell Tumors of the Extremities.

Purpose: To investigate the local recurrence rate, joint preservation status, and functional outcomes after extended curettage and postoperative denosumab treatment for Campanacci Grade III giant cell tumors of the extremities.

Methods: We retrospectively reviewed 23 patients with Campanacci Grade III GCTB of the extremities in our hospital between January 2017 and June 2023 who underwent extended curettage and postoperative denosumab administration alone, without preoperative denosumab treatment. Patients were followed-up for adverse events of denosumab, surgical outcomes, limb function of lesions, and local recurrence following extended curettage with postoperative denosumab.

Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C).

Long QT syndrome type 2 (LQT2), caused by mutations in the KCNH2 gene, is an inherited ion channel disorder associated with sudden death in adolescents. In this study, we generated a patient-specific induced pluripotent stem cell (iPSC) line XXMUFAi001-A using non-integrative Sendai reprogramming technology from an individual carrying a heterozygous point mutation (c.2690 A>C) in KCNH2.

Phototheranostics: An advanced approach for precise diagnosis and treatment of gynecological inflammation and tumors.

Gynecological inflammations have a significant impact on the daily lives of women. Meanwhile, cancers such as ovarian, cervical, and endometrial cancers pose severe threats to their physical and mental well-being. While current options such as conventional pharmacotherapy, surgical interventions, and recent advancements in immunotherapy and targeted therapy provide viable solutions, they possess limitations in effectively addressing the intricacies associated with gynecological diseases.

Research Progress on the Mechanism and Application of the Type I CRISPR-Cas System.

The CRISPR-Cas system functions as an adaptive immune mechanism in archaea and bacteria, providing defense against the invasion of foreign nucleic acids. Most CRISPR-Cas systems are classified into class 1 or class 2, with further subdivision into several subtypes. The primary distinction between class 1 and class 2 systems lies in the assembly of their effector modules.

Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank.

Objectives: This study aimed to assess the impact of modifiable lifestyle behaviors on the association between sleep patterns and chronic kidney disease (CKD) risk.

Methods: This study included 294,215 UK Biobank participants initially without CKD, followed until 13 October 2023. Sleep patterns were derived from five sleep factors, including sleep duration, chronotype, insomnia, snoring, and daytime dozing.

High AIPH-Loaded Infinite coordination Polymers nanoparticles for long-term thermodynamic-chemo cascade tumor synergistic therapy.

To enhance the tumor thermodynamic-chemo synergistic therapy efficacy, high loading of AIPH-Cu(II)-AQ4N Infinite Coordination Polymer nanoparticles (ICP NPs) were developed, which have high AIPH loading of 44.5 %, thermal stability, pH responsive release all therapeutic agents in the tumor tissue and lower toxicity. A long-term thermodynamic-chemo cascade tumor synergistic therapy strategy was developed with these nanoparticles.

Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder: A Randomized Clinical Trial.

Importance: Evidence from randomized clinical trials of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia disorder is lacking.

Objective: To evaluate the efficacy and safety of taVNS for chronic insomnia compared with the sham taVNS.

Design, Setting, And Participants: This randomized clinical trial was conducted from October 2021 to December 2022 at a single center in Beijing, China.

Stereochemical Activity and Luminescence Mechanism in (CHN)SnCl Doped with ns Metal Ions.

Metal halide luminescent materials, particularly those doped with ns ions, exhibit exceptional optical properties. However, the luminescent mechanisms associated with the stereochemical activity of lone-pair electrons remain insufficiently explored. In this study, zero-dimensional (0D) tin-based halide (CHN)SnCl is utilized as a model system to investigate the effects of lattice distortion and lone-pair electron expression on fluorescence emission characteristics by doping with 6s and 5s ions.

Dual-tower model with semantic perception and timespan-coupled hypergraph for next-basket recommendation.

Next basket recommendation (NBR) is an essential task within the realm of recommendation systems and is dedicated to the anticipation of user preferences in the next moment based on the analysis of users' historical sequences of engaged baskets. Current NBR models utilise unique identity (ID) information to represent distinct users and items and focus on capturing the dynamic preferences of users through sequential encoding techniques such as recurrent neural networks and hierarchical time decay modelling, which have dominated the NBR field more than a decade. However, these models exhibit two significant limitations, resulting in suboptimal representations for both users and items.

Preparation and Investigation of Temperature-Responsive SiO-PSBMA Janus Nanosheet with Salt-Tolerant Properties for Enhanced Recovery of Heavy Oil.

Enhancing heavy oil recovery is crucial to ensuring stable crude oil production. The development of stimulus-responsive Janus Pickering emulsifiers tailored for a reservoir environment has garnered significant attention in the field of reservoir production, emerging as a promising alternative to traditional surfactants. In this study, silica-based Janus nanosheets with temperature-responsive properties (OH-SiO-PSBMA JNs) are synthesized using sol-gel process and atom transfer radical polymerization (ATRP) method.

MAM-STAT3-Driven Mitochondrial Ca Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients.

Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia-(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown. Herein, it is shown that MAD patients achieved inflammaging with different pro-inflammatory cytokines compared to progeria-(HGPS) patient.

The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.

Long non-coding RNA (lncRNA)-encoded small proteins play a major role in colorectal cancer. To identify more functional encoded small proteins, ribosome profiling data from colorectal cancer (CRC) cells were screened for ribosome-associated lncRNAs. The search identified LINC01547 that was shown to encode a small protein of 76 amino acids, termed LINC01547-ORF.

Synthesis of novel deuterated EGFR/ALK dual-target inhibitors and their activity against non-small cell lung cancer.

EGFR and ALK are common driver genes in NSCLC, and more patients with these mutations are being identified due to medical advances. Thus, developing dual-target EGFR/ALK inhibitors is crucial. In this study, 10 novel small molecules were designed and synthesized.

Withdrawn: Long non-coding RNA SNHG1 promotes cell proliferation and invasion of hepatocellular carcinoma by acting as a molecular sponge to modulate miR-195.

[This retracts the article DOI: 10.5114/aoms.2019.

Evaluating CNN Architectures for the Automated Detection and Grading of Modic Changes in MRI: A Comparative Study.

Objective: Modic changes (MCs) classification system is the most widely used method in magnetic resonance imaging (MRI) for characterizing subchondral vertebral marrow changes. However, it shows a high degree of sensitivity to variations in MRI because of its semiquantitative nature. In 2021, the authors of this classification system further proposed a quantitative and reliable MC grading method.