Boosted Oxygen Evolution Reactivity via Atomic Iron Doping in Cobalt Carbonate Hydroxide Hydrate.

Cobalt carbonate hydroxide hydrate (CCHH) has long been functioning merely as a precursor to prepare compound catalysts; however, its intrinsic potential for the oxygen evolution reaction (OER) is quite limited due to its poor catalytic activity. Herein, a concept has been proposed to solve this issue by doping Fe into CCHH nanowires grown on nickel foam (denoted as Fe-CCHH/NF) for achieving efficient OER catalysis by electrochemical transformation. The obtained Fe-CCHH/NF-30 exhibits OER catalytic performance with an overpotential of only 200 mV versus the reversible hydrogen electrode (vs.

The Correlation of Family Resilience with Sleep Quality and Depression of Parents of Children with Epilepsy.

Purpose: The present study aims to investigate the correlation between family resilience, sleep quality, and depression in parents of children with epilepsy.

Design And Methods: The parents of 157 children with epilepsy were assessed using the shortened Chinese version of the Family Resilience Assessment Scale (FRAS-SC) to measure the resilience level of families of children with epilepsy. The Pittsburgh Sleep Quality Index (PSQI) was used to determine the sleep quality of the subjects.

[Research Advance on the Immune Escape of Acute Myeloid Leukemia--Review].

Acute myeloid leukemia (AML) is a kind of malignant hematological disease with high mortality. Patients 5-year survival rate is less than 25% and that of elderly patients is lower than 10%. Although the standardized chemotherapy or hematopoetic stem cell transplantation can significantly improve the therapeutic efficacy for AML, but disease recurrence is still a difficult problem in most patients.

Predictive and prognostic value of EPIC1 in patients with breast cancer receiving neoadjuvant chemotherapy.

Background: EPIC1 is an oncogenic long non-coding ribonucleic acid (RNA) that promotes cell growth and cell-cycle progression and inhibits apoptosis in several cancer cell lines. However, clinical studies on EPIC1 in breast cancer, specifically in the neoadjuvant setting, are relatively few.

Methods: Patients treated with weekly paclitaxel-cisplatin-based neoadjuvant chemotherapy after core-needle biopsy were included in the study.

Erythropoietin prevents necrotizing enterocolitis in very preterm infants: a randomized controlled trial.

Background: Necrotizing enterocolitis (NEC) is one of the most severe complications in very preterm infants, but there are currently no accepted methods to prevent NEC. Studies have shown that erythropoietin (EPO) has the potential to prevent NEC or improve outcomes of preterm NEC. This study aimed to determine whether recombinant human EPO (rhEPO) could protect against NEC in very preterm infants.

The prevalence of pathogens causing bovine mastitis and their associated risk factors in 15 large dairy farms in China: An observational study.

The primary objective of this study was to determine the distribution of major pathogens causing mastitis and analyze the association of the main pathogens with the type of milk {milk samples collected from cows with mastitis of different severities, which consisted of subclinical mastitis (Lanzhou Mastitis Test weak positive, positive, and strong positive) and clinical mastitis}, region, season, bedding material, parity and lactation stage on large dairy farms. Fifteen large dairy farms in twelve major milk-producing provinces of China were enrolled in the study for approximately one year; 1,153 mastitis milk samples were collected and processed. The most frequently isolated pathogens were Staphylococcus spp.

Birth Asphyxia Is Associated With Increased Risk of Cerebral Palsy: A Meta-Analysis.

To assess the association between birth asphyxia-as defined by the pH of umbilical cord blood-and cerebral palsy in asphyxiated neonates ≥35 weeks' gestation. Two reviewers independently selected English-language studies that included data on the incidence of cerebral palsy in asphyxiated neonates ≥35 weeks' gestation. Studies were searched from the Embase, Google Scholar, PubMed, and Cochrane Library databases up to 31 December 2019, and the references in the retrieved articles were screened.

Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S.

Many saponins are characterized as exhibiting a wide spectrum of antitumor activities at low concentrations. Most of the previous studies that aimed to understand the mechanisms underlying anticancer saponins have focused on numerous classical signaling pathways. However, at the oncogene level, little is known about the action of saponins, especially asterosaponin.

Identification of a Hyperparasitic Strain Affecting the Infection Dynamics of f. sp. on Wheat.

Wheat stripe rust, caused by f. sp. (), is one of the most serious threats to wheat production worldwide.

Ethyl pyruvate inhibits glioblastoma cells migration and invasion through modulation of NF-κB and ERK-mediated EMT.

Background: Glioblastoma is a grade IV glioma with the highest degree of malignancy and extremely high incidence. Because of the poor therapeutic effect of surgery and radiochemotherapy, glioblastoma has a high recurrence rate and lethality, and is one of the most challenging tumors in the field of oncology. Ethyl pyruvate (EP), a stable lipophilic pyruvic acid derivative, has anti-inflammatory, antioxidant, immunomodulatory and other cellular protective effects.

Long noncoding RNA MIAT promotes non-small cell lung cancer progression by sponging miR-149-5p and regulating FOXM1 expression.

Background: Long non-coding RNAs (lncRNAs) are a class of endogenous non-coding RNAs of longer than 200 bp that play crucial roles in cancer biology. Here, we assessed the tumorigenic properties of a long noncoding RNA, MIAT, in non-small cell lung cancer (NSCLC).

Methods: Survival and clinicopathological analyses were done in a cohort of 80 patients with NSCLC.

An investigation into the allosteric mechanism of GPCR A adenosine receptor with trajectory-based information theory and complex network model.

G protein-coupled receptors (GPCRs), a large superfamily of transmembrane (TM) proteins, allosterically transduce the signal of ligand binding in the extracellular (EC) domain to couple to effector proteins in the intracellular (IC) domain, therefore forming the largest class of drug targets. The A adenosine receptor (AAR), a class-A GPCR, has been extensively studied as it offers numerous possibilities for therapeutic applications. However, the mechanism of allosteric communication between EC and IC domains is not completely clear.

Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene.

Public health interventions to control the recent emergence of plasmid-mediated tigecycline resistance genes rely on a comprehensive understanding of its epidemiology and distribution over a wide range of geographical scales. Here we analysed an Escherichia coli collection isolated from pigs and chickens in China in 2018, and ascertained that the tet(X4) gene was not present at high prevalence across China, but was highly endemic in northwestern China. Genomic analysis of tet(X4)-positive E.

Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism.

Bacteria sense and respond to environmental changes via several broad categories of sensory signal transduction systems. Recently, we described the key features of a previously unrecognized, but widely conserved class of prokaryotic sensory system that we refer to as the LytTR Regulatory System (LRS). Our previous studies suggest that most, if not all, prokaryotic LRS membrane proteins serve as inhibitors of their cognate transcription regulators, but the inhibitory mechanisms employed have thus far remained a mystery.

Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma.

Regorafenib is a second-line therapy drug used for advanced hepatocellular carcinoma (HCC). Unfortunately, the survival benefit of the patients receiving this treatment is modest, which may be attributed to drug resistance. In the present study, sphingosine kinase 2 (SphK2) was targeted to reverse regorafenib resistance in HCC.

Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment.

Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body-integrated sensors, including skin-mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human-biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications.

Experimental immunization of mice with a recombinant bovine enterovirus vaccine expressing BVDV E0 protein elicits a long-lasting serologic response.

Background: Bovine viral diarrhea virus (BVDV) is a cause of substantial economic loss to the cattle industry worldwide, and there are currently no effective treatment or preventive measures. Bovine enterovirus (BEV) has a broad host range with low virulence and is a good candidate as a viral vaccine vector. In this study, we explored new insertion sites for the expression of exogenous genes in BEV, and developed a recombinant infectious cDNA clone for BEV BJ101 strain expressing BVDV E0 protein.

Incidence and risk factors of type 2 diabetes mellitus in individuals with different fasting plasma glucose levels.

Objective: Our aim was to examine the incidence and risk factors of type 2 diabetes mellitus (T2DM) among individuals with different fasting plasma glucose (FPG) levels.

Methods: According to the first FPG value recorded between January 2006 and December 2017, individuals without T2DM (FPG <7 mmol/L) were divided into three groups: normal fasting glucose (NFG, FPG < 5.6 mmol/L), slightly impaired fasting glucose (IFG, 5.

Correction to 'Cytotoxicity studies of FeO nanoparticles in chicken macrophage cells'.

[This corrects the article DOI: 10.1098/rsos.191561.

Three-Dimensional Molybdenum Diselenide Helical Nanorod Arrays for High-Performance Aluminum-Ion Batteries.

The rechargeable aluminum-ion battery (AIB) is a promising candidate for next-generation high-performance batteries, but its cathode materials require more development to improve their capacity and cycling life. We have demonstrated the growth of MoSe three-dimensional helical nanorod arrays on a polyimide substrate by the deposition of Mo helical nanorod arrays followed by a low-temperature plasma-assisted selenization process to form novel cathodes for AIBs. The binder-free 3D MoSe-based AIB shows a high specific capacity of 753 mAh g at a current density of 0.

The Effector GpPDI1 Is a Functional Thioredoxin and Triggers Defense-Related Cell Death Independent of Its Enzymatic Activity.

The plant-parasitic nematode is an obligate biotroph that only reproduces on select species in the family. The establishment of the feeding site, the syncytium, involves secretion of effectors into the plant cell to combat the plant defense response and facilitate transformation of root cells into the syncytium. Despite the important predicted roles of effectors in the plant-pathogen interactions, the functionality of effectors is largely unknown.

Cytotoxicity studies of FeO nanoparticles in chicken macrophage cells.

Magnetic FeO nanoparticles (FeO-NPs) have been widely investigated for their biomedical applications. The main purpose of this study was to evaluate the cytotoxic effects of different sizes of FeO-NPs in chicken macrophage cells (HD11). Experimental groups based on three sizes of FeO-NPs (60, 120 and 250 nm) were created, and the FeO-NPs were added to the cells at different doses according to the experimental group.