Live Attenuated aTJ Vaccine Effectively Protects Pigeons Against Homologous PPMV-1 Challenge.

Pigeon paramyxovirus type 1 (PPMV-1) is a significant pathogen affecting pigeon populations globally. The commonly used La Sota vaccine provides limited protection due to antigenic divergence from circulating PPMV-1 strains. An antigenically matched vaccine is needed to address this challenge.

The Emerging Role of Schwann Cells in the Tumor Immune Microenvironment and Its Potential Clinical Application.

As the primary glial cells in the peripheral nervous system (PNS), Schwann cells (SCs) have been proven to influence the behavior of cancer cells profoundly and are involved in cancer progression through extensive interactions with cancer cells and other stromal cells. Indeed, the tumor microenvironment (TME) is a critical factor that can significantly limit the efficacy of immunotherapeutic approaches. The TME promotes tumor progression in part by reshaping an immunosuppressive state.

Radar-Terahertz-Infrared Compatible Stealth Coaxial Silver Nanowire@Carbon Nano-cable Aerogel.

Achieving multi-spectrum compatible stealth in radar-terahertz-infrared bands with robust performance has great prospects for both military and civilian applications. However, the progress of materials encounters substantial challenges due to the significant variability in frequency coupling properties across different electromagnetic wave bands. Here, this work presents the design of a multi-scale structure and fabricates a lightweight aerogel (silver nanowire@carbon, AgNW@C) consisting of a regular coaxial nano-cable, with silver nanowire as the core and amorphous-graphitized hybrid carbon as the outer-layer.

Genome-scale metabolic modelling reveals interactions and key roles of symbiont clades in a sponge holobiont.

Sponges harbour complex microbiomes and as ancient metazoans and important ecosystem players are emerging as powerful models to understand the evolution and ecology of symbiotic interactions. Metagenomic studies have previously described the functional features of sponge symbionts, however, little is known about the metabolic interactions and processes that occur under different environmental conditions. To address this issue, we construct here constraint-based, genome-scale metabolic networks for the microbiome of the sponge Stylissa sp.

UV-B induced flavonoid accumulation and related gene expression in blue- grained wheat at different periods of time.

Introduction: UV-B can be used as an additional technique for nutrient accumulation in blue-grained wheat, which has special nutritional properties due to its blue starch layer. The concentration of flavonoids in blue-grained wheat under UV-B irradiation is extremely important for further investigation and exploitation of the nutritional properties of blue-grained wheat.

Methods: This investigation focuses on the expression of flavonoids and associated genes in blue-grained wheat using transcriptomic and metabolomic analyzes.

Extraction, purification, structural characterization, and bioactivities of Radix Aconiti Lateralis Preparata (Fuzi) polysaccharides: A review.

Radix Aconiti Lateralis Preparata (Fuzi) polysaccharide (FZP) is a key bioactive macromolecule derived from the root of Aconitum carmichaeli Debx. FZP has a variety of biological activities, including immunomodulatory, anti-tumor, anti-depressant, organ-protective, hypoglycemic, anti-inflammatory, and other activities. The biological activities of polysaccharides are closely related to their structures, and different extraction and purification methods will yield different polysaccharide structures.

Prevalence and risk factors of pre-frailty and frailty in hemodialysis patients in central China.

The current study was to explore the prevalence and risk factors elements of pre-frailty and frailty among patients undergoing hemodialysis (HD) in central China. A cross-sectional, multi-institutional investigation was conducted. From March to May 2024, using the convenience sampling method, a total of 408 HD patients from four hospitals in Xiangyang, China, were recruited for this study.

Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer.

In pancreatic cancer, significant alterations occur in the local nervous system, including axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic cancer can impact the central nervous system (CNS) through cancer cell-intrinsic factors or systemic factors, particularly in the context of cancer cachexia. These peripheral and central neuropathic changes exert substantial influence on cancer initiation and progression.

Reconfigurations of dynamic functional network connectivity after 1HZ repetitive transcranial magnetic stimulation in insomnia disorder.

Aims: The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks.

FeCu-N6-C Diatomic Sites Catalyst for the Boosted Oxygen Reduction Reactions in Zinc-air Batteries.

Due to the high catalytic activity and stability for oxygen reduction reaction, N-coordinated Fe-Cu dual-metal doped carbon material (FeCu-N-C) is considered to be one of the promising electrode materials for metal-air battery and fuel cells. Herein, FeCu-N-C dual-metal catalysts was synthesized by an adsorption-calcination strategy. The prepared FeCu-N-C exhibited high activity and stability both in alkaline and acidic media.

Telitacicept for refractory cystitis associated with severe systemic lupus erythematosus: A case report.

Background: Lupus cystitis, a severe complication of systemic lupus erythematosus (SLE), presents considerable treatment challenges.

Purpose: This case report describes the use of telitacicept in treating severe SLE with lupus cystitis.

Research Design: A single patient with lupus cystitis.

Exploring the interplay of academic stress, motivation, emotional intelligence, and mindfulness in higher education: a longitudinal cross-lagged panel model approach.

Students in higher education often encounter significant academic pressure, which can have profound implications for their mental health and academic performance. The current study employs a two-wave longitudinal design to investigate the dynamic interrelationships among academic stress, academic motivation, emotional intelligence, and mindfulness. The study employed a cross-lagged panel model to investigate the temporal interactions among these four constructs and their influence on the academic experiences of doctoral students.

Bisulfite-Free and Quantitative Detection of DNA Methylation at Single-Base Resolution by eROS1-seq.

5-Methylcytosine (5mC) is the most significant DNA modification present in mammalian genomes. Understanding the roles of 5mC in diverse biological processes requires quantitative detection at single-base resolution. In this study, we engineered the repressor of the silencing 1 (ROS1) protein derived from to enhance its 5mC glycosylase/lyase activity, resulting in the creation of the engineered ROS1 (eROS1) protein.

An Fe-doped Ni-based oxalate framework with a favorable electronic structure for electrocatalytic water and urea oxidation.

An Fe-doped Ni-based oxalate framework, synthesized a facile co-precipitation method, is applied as an excellent bi-functional electrocatalyst for water and urea oxidation reactions. The obtained framework achieved a large current density of 100 mA cm at 1.497 V and 1.

Scutellarin: pharmacological effects and therapeutic mechanisms in chronic diseases.

Scutellarin (SCU), a flavonoid glucuronide derived from and , exhibits broad pharmacological effects with promising therapeutic potential in treating various chronic diseases. It has demonstrated efficacy in modulating multiple biological pathways, including antioxidant, anti-inflammatory, anti-apoptotic, and vasodilatory mechanisms. These protective roles make SCU a valuable compound in treating chronic diseases such as cerebrovascular diseases, cardiovascular diseases, neurodegenerative disorders, and metabolic diseases.

New insights into the role of lipids in aroma formation during black tea processing revealed by integrated lipidomics and volatolomics.

Lipids are important tea aroma precursors. Due to the complexity of black tea processing involving both enzymatic and thermal reactions, the role of lipids in black tea aroma formation remained unclear. Herein, the dynamic changes of lipids and volatiles during black tea processing were simultaneously analyzed by lipidomics and volatolomics using ultra-high-performance liquid chromatography coupled to Q-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive) and gas chromatography-tandem mass spectrometry (GC-MS/MS).

AIGen: an artificial intelligence software for complex genetic data analysis.

The recent development of artificial intelligence (AI) technology, especially the advance of deep neural network (DNN) technology, has revolutionized many fields. While DNN plays a central role in modern AI technology, it has rarely been used in genetic data analysis due to analytical and computational challenges brought by high-dimensional genetic data and an increasing number of samples. To facilitate the use of AI in genetic data analysis, we developed a C++ package, AIGen, based on two newly developed neural networks (i.

Oxide-Metal Hybrid Glass Nanomembranes with Exceptional Thermal Stability.

Contrary to oxide or polymeric glasses, metallic glasses are infamously known for their relatively limited thermal stability, which is often characterized by their narrow supercooled liquid regions. Nonetheless, we successfully fabricated metallic-glass based nanomembranes with an ultrahigh thermal ability by a polymer surface buckling enabled exfoliation technique. These nanomembranes exhibit a distinctive nanostructure with nanosized metallic-glasses encapsulated within an interconnected nanoamorphous-oxide network.