[Clinical analysis and follow-up results of 25 children with glycogen storage disease].

To investigate the clinical characteristics, genetic characteristics and follow-up of hepatic glycogen accumulation in order to further improve the prognosis of children with hepatic glycogen accumulation. Clinical data of hospitalized children diagnosed with hepatic glycogen accumulation disease in the Department of gastroenterology, Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2010 to April 2023 were collected and retrospectively analyzed. The results of laboratory examination and gene sequencing were analyzed, and the patients with more than 3 cases (n) were grouped according to the genetic results: Group 1 was type Ⅰ (=8), group 2 was type Ⅲ (=5), and group 3 was type Ⅸ a (=8).

The gut microbial metabolite indole-3-aldehyde alleviates impaired intestinal development by promoting intestinal stem cell expansion in weaned piglets.

Background: Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota dysbiosis. However, it has been challenging to clarify which specific intestinal microbiota and their metabolites play a crucial role in the antidiarrhea process of weaned piglets.

Results: In this study, we first observed that piglets with diarrhea exhibited a lower average daily gain and higher diarrhea score, and elevated levels of lipopolysaccharide (LPS) and D-lactate (D-LA) compared to healthy piglets.

ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts.

Background: Although the exact role of mitophagy in the pathogenesis of diabetic cardiomyopathy (DCM) caused by type 2 diabetes mellitus (T2DM) remains controversial, recent studies revealed inhibition of mitophagy exacerbates cardiac injury in DCM. The zinc transporter ZIP7 has been reported to be upregulated by high glucose in cardiomyocytes and ZIP7 upregulation leads to inhibition of mitophagy in mouse hearts in the setting of ischemia/reperfusion. Nevertheless, little is known about the role of ZIP7 and its relationship with mitophagy in DCM caused by T2DM.

Deciphering the complex organelle genomes of two Rhododendron species and insights into adaptive evolution patterns in high-altitude.

Background: The genomes within organelles are crucial for physiological functions such as respiration and photosynthesis and may also contribute to environmental adaptation. However, the limited availability of genetic resources, particularly mitochondrial genomes, poses significant challenges for in-depth investigations.

Results: Here, we explored various assembly methodologies and successfully reconstructed the complex organelle genomes of two Rhododendron species: Rhododendron nivale subsp.

Reliability of interobserver and intraobserver assessments of the Tile versus Young-Burgess classifications for pelvic ring injuries.

Tile and Young-Burgess classification systems have been widely used to classify pelvic ring injuries in clinical settings; however, these two systems are rarely mentioned in the literature despite their reproducibility and practical application. The purpose of this study was to assess the interobserver and intraobserver reliability of the Tile and Young-Burgess classification of pelvic ring injuries. Eight hundred seven patients with pelvic fractures who presented to two I-level trauma centres between January 2016 and June 2020 were recruited for this study.

Visual Quality Following Femtosecond Laser-Assisted In Situ Keratomileusis With Q-Value-Guided Optimized Monovision in Patients With Myopia and Presbyopia.

Purpose: To evaluate the objective and subjective visual quality 3 months after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) performed with Q-value-guided optimized monovision scheme (Custom-Q) for correction of myopia with or without astigmatism and compensate for age-related accommodation deficiency.

Design: Prospective before-and-after study.

Methods: Patients who had Custom-Q FS-LASIK for myopia with age-related accommodation deficiency were included in this prospective study.

Improved volatile fatty acid production in anaerobic digestion via simultaneous temperature regulation and persulfate activation by biochar: Chemical and biological response mechanisms.

Increasing volatile fatty acid (VFA) production via persulfate activation (i.e., chemical effect) in anaerobic digestion (AD) is an emerging resource utilization method.

Assessment tools of the fear of falling: A scoping review.

Aim: To comprehensively evaluate and synthesize fear of falling assessment tools and their psychometric properties.

Methods: The literature in PubMed, Web of Science Core Collection, Cochrane Library, Embase, Google Scholar, CNKI, Wanfang, VIP, and CBM was systematically searched, and the search period was from the establishment of the database to September 1, 2023, and updated on September 1, 2024.

Results: A total of 104 documents covering 19 assessment tools were included.

The brain topological alterations in the structural connectome and correlations with clinical characteristics in type 1 narcolepsy.

Objective: To explore topological alterations of white matter (WM) structural connectome, and their associations with clinical characteristics in type 1 narcolepsy (NT1).

Methods: 46 NT1 patients and 34 age- and sex-matched healthy controls were recruited for clinical data and diffusion tensor imaging collection. Using graph theory analysis, the topology metrics of structural connectome, rich club organization, and connectivity properties were compared between two groups.

ESMR4FBP: A pLM-based regression prediction model for specific properties of food-derived peptides optimized multiple bionic metaheuristic algorithms.

Due to the growing emphasis on food safety, peptide research is increasingly focusing on food sources. Traditional methods for determining peptide properties are expensive. While artificial intelligence (AI) models can reduce cost, existing peptide models often lack accuracy.

Epidemiological and genomic analysis revealed the significant role of flies in dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in China.

While the role of flies as potential vectors for bacterial transmission is well recognized, the epidemiological features and genomic characteristics of associated antimicrobial-resistant strains remain underexplored. This study conducted a nationwide surveillance including 3689 flies and 838 isolates from sixteen human communities (HCs) and eight animal farms (AFs) across 21 provinces in China. Our findings revealed high carriage rates of carbapenem-resistant Enterobacteriaceae (CRE) in flies, with 27.

Oxygen Vacancies and Lattice Distortion Synergistically Enhanced Piezocatalysis of CaZn(BO) for Nonantibiotic Pharmaceutical Degradation.

Piezocatalysis, an emerging green and advanced oxidation technology, has recently been widely researched in environmental treatment. However, the limited polarization efficiency of the piezocatalyst is a serious bottleneck for its practical application. The search for an excellent piezocatalyst with a high piezoelectric coefficient and abundant reactive sites remains an urgent task that needs to be developed.

Narrative competence disparities between Children's hospital and General hospital in China: A comparative survey.

Background: Narrative medicine was introduced in China in 2011 and has been applied as a tool for humane medical practice. The prominent problem in the narrative medicine is the lack of adequate attention and devotion. This study aimed to investigate Chinese medical staffs' narrative competence and the influencing factors, confirming whether the level of narrative competence is different in different hospital settings.

Ultrasound-Responsive Lipid Nanoplatform with Nitric Oxide and Carbon Monoxide Release for Cancer Sono-Gaso-Therapy.

Local gas therapy is emerging as a potential cancer treatment approach due to its specificity as gas-containing molecules can be packed into a nanodelivery system to release the corresponding gaseous molecules around the tumor site upon a suitable stimulus. Single-gas therapy has been reported, while synergistic dual-gas therapy has rarely been reported. Herein, we report a dual-gas-containing nanoplatform for synergistic cancer gasotherapy upon ultrasound irradiation.

Antibiotic-resistant genes derived from commercial organic fertilizers are transported to balconies of residential buildings by express delivery.

The rise in antibiotic-resistant genes (ARGs) has recently become a pressing issue, with livestock manure identified as a significant source of these genes. Yet, the distribution of fertilizers derived from livestock manure sold online, potentially containing high levels of ARGs and antibiotic-resistant bacteria (ARB), is often not considered. Our study involved a random survey of commercial organic fertilizers available on online marketplaces, focusing on 13 common ARGs and 2 integrons (intI1, intI2).

Identification of the Biomarkers for Chronic Gastritis with TCM Damp Phlegm Pattern by Using Tongue Coating Metabolomics.

Objective: This study aimed to establish a model for identifying chronic gastritis with the traditional Chinese medicine damp phlegm pattern by examining metabolite changes in the tongue coating of patients. It also explored the role of metabolic pathways in the pathogenesis of this condition.

Methods: This cross-sectional study involved 300 patients diagnosed with chronic gastritis.

Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia: a multicenter, randomized trial.

Realgar-Indigo Naturalis Formula (RIF) is an oral form of arsenic that is effective against acute promyelocytic leukemia (APL). This multicenter, randomized, controlled trial compared the efficacy of all-trans retinoic acid (ATRA) plus RIF with ATRA plus arsenic trioxide (ATO) in a simplified regimen for non-high-risk APL. Following induction therapy with ATRA and ATO, participants were randomly assigned to receive either ATRA plus ATO or ATRA plus RIF both in a 2-week on 2-week off schedule for consolidation therapy.

IGF2BP3/CTCF Axis-Dependent NT5DC2 Promotes M2 Macrophage Polarization to Enhance the Malignant Progression of Lung Squamous Cell Carcinomas.

Background: Lung squamous cell carcinoma (LUSC) is a type of lung cancer that develops in the squamous cells. It is known to be promoted by the activation of various signaling pathways and the dysregulation of key regulatory molecules. One such molecule, 5'-nucleotidase domain containing 2 (NT5DC2), has been identified as a critical regulator in various cancers including lung cancer.

Clinical Characteristics and Prognostic Factors for Adult HIV-Negative Burkitt Lymphoma: a Single-Center Retrospective Study.

Background: We performed a retrospective cohort study to examine the clinical characteristics, prognosis factors, and survival outcomes of HIV-negative adult Burkitt's lymphoma.

Methods: The retrospective study was conducted on adult patients, who were diagnosed with HIV-negative Burkitt lymphoma at our center between 2014 and 2022. Univariate and multivariate Cox regression analyses were conducted to identify potential risk factors for mortality.

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling.

The Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β) signalling. However, recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors including G protein-coupled receptors (GPCR). The versatility of Smad transcription factors originated from the two regions that can be differently activated by the TGF-β receptor superfamily or through the recruitment of intracellular kinases stimulated by other receptors classes such as GPCRs.