Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder.

Post traumatic stress disorder (PTSD) is a serious and persistent mental diseases. Nowadays, Treatment of PTSD patients in clinical practice is mainly based on drug therapy accompanied by psychological therapy. However, the therapeutic effect is unsatisfactory.

Bacterial biofilm-based bioleaching: Sustainable mitigation and potential management of e-waste pollution.

Significant advances in the electrical and electronic industries have increased the use of electrical and electronic equipment and its environmental emissions. The e-waste landfill disposal has deleterious consequences on human health and environmental sustainability, either directly or indirectly. E-waste containing ferrous and non-ferrous materials can harm the surrounding aquatic and terrestrial environments.

Generation of the broadband indistinguishable two-photon state in the telecom band.

The indistinguishable photon-pair sources are valuable in many quantum information applications, such as quantum microscopy, quantum synchronization, and quantum metrology. Based on cascaded sum-frequency generation (SFG) and spontaneous parametric downconversion (SPDC) processes, we propose and demonstrate a scheme for the generation of spatially separated broadband indistinguishable photon pairs in the telecom band by using only one piece of a fiber-pigtailed periodically poled lithium niobate waveguide in a modified Sagnac loop. The measured joint spectral intensity of the generated entangled photon pairs is 7.

Evaluation of the Accuracy of Digital Impression Techniques Based on an Integrated ADA Model.

Objective: The purpose of this in vitro study was to assess and compare the accuracy of three digital impression techniques based on an innovative integrated model.

Materials And Methods: The integrated model was created by incorporating crown, inlay, and long-distance specimens from the American Dental Association (ADA) Standard No. 132.

Synthesis of epitaxial LuN films.

Epitaxy of rare-earth nitride films are crucial for studying their physical properties and offer significant potential for applications in spintronics and optoelectronics. However, synthesizing single-crystalline LuN presents significant challenges, leading to a limited understanding of its properties. In this study, we successfully achieved the epitaxial growth of (001)-oriented LuN films on YAlO (110) substrates by reactive magnetron sputtering epitaxy.

Outcomes and Risk Factors in Patients with Hematologic Malignancies Following Late-Stage SARS-CoV-2 Infection.

Purpose: To investigate the outcomes and risk factors for patients with hematologic malignancies (HM) following late-stage SARS-CoV-2 infection.

Background: Patients with HM such as lymphoproliferative malignancies (including acute lymphoblastic leukemia and multiple myeloma) and myeloproliferative malignancies (including acute myeloid leukemia, myeloproliferative neoplasm, and myelodysplastic syndrome) are at increased risk of severe illness and high mortality from COVID-19. This study examines the impact of SARS-CoV-2 infection severity on HM prognosis during the late phase of COVID-19, using data from 203 patients at Shanxi Bethune Hospital.

The Role of NDRG1 Expression in Vasculogenic Mimicry of High-grade Gliomas.

Glioma is one of the most common primary malignant tumors of the central nervous system, and the prognosis is getting worse with the improvement of tumor grade. In recent years, with the in-depth study of the disease, researchers have found that microvascular mimicry seems to be the key factor of poor prognosis, but its specific mechanism has not been thoroughly studied, and the expression of microvascular mimicry in high-grade gliomas is closely related to the expression of NDRG1 gene. This research project is expected to control the occurrence and development of HGG by exploring the factors that affect the expression of NDRG1 gene.

Mapping the AIDS Week Health Campaign on Social Media in China: A Mixed-Method Study.

This study aimed to explore the dissemination of HIV/AIDS-related information and risk factors on social media during AIDS Weeks, helping policymakers and public health organizations understand how the public utilizes social media to formulate strategies for AIDS health campaigns better. This study used Latent Dirichlet Allocation (LDA) topic modeling and sentiment analysis to investigate the distribution of themes and people's reactions during AIDS Weeks. Additionally, Critical Discourse Analysis (CDA) was employed to further examine the social structures, cultural contexts, and power dynamics underlying the discourse.

Highly Dispersed AuCu Nanoparticles Confined in Zr-MOFs for Efficient Methanol Synthesis from CO Hydrogenation.

Making use of novel materials to develop efficient catalysts is one of the research hotspots for CO hydrogenation to methanol. Herein, UiO-66, a typical Zr-MOF, was modified by ethylene diamine tetraacetic acid (EDTA) to serve as a substrate for the synthesis of AuCu bimetallic catalysts. The resultant AuCu@UiO-66-EDTA catalyst exhibited a superior methanol production rate, which delivered a high space-time yield of methanol (3.

Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications.

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating the treatment of skin infections caused by pathogens such as bacteria, fungi, and viruses through topical methods. In this research, a microneedle patch was developed, which consists of gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at the tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served as the primary substrate for the microneedle shaft (PDA@Cu-SG/PEGDA).

An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates.

Duplication of methyl-CpG-binding protein 2 (MECP2) gene causes MECP2 duplication syndrome (MDS). To normalize the duplicated MECP2 in MDS, we developed a high-fidelity Cas13Y (hfCas13Y) system capable of targeting the MECP2 (hfCas13Y-gMECP2) messenger RNA for degradation and reducing protein levels in the brain of humanized MECP2 transgenic mice. Moreover, the intracerebroventricular adeno-associated virus (AAV) delivery of hfCas13Y-gMECP2 in newborn or adult MDS mice restored dysregulated gene expression and improved behavior deficits.

[Analytical performance evaluation of Flash10 point-of-care testing in severe acute respiratory syndrome coronavirus 2 nucleic acid detection].

To evaluate the analytical performance of Flash10 point-of-care testing (POCT) in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid. The analytical performance evaluation of the Flash10 POCT system and its matching kits was carried out based on the non-infectious phage virus-like particles (VLPs) samples and inactivated viral culture samples. The limit of detection (LoD) was evaluated by testing gradient-diluted non-variant and Omicron variants (BA.

Alstoscholarisine L, a novel caged monoterpenoid indole alkaloid with antifungal activity from Alstonia scholaris.

Alstoscholarisine L is an architecturally complex monoterpenoid indole alkaloid with a unique ring fusion pattern, isolated from the leaves of Alstonia scholaris. The 6/5/5/6/6/6-membered rings contain two lactonic rings and one aminal carbon and possess seven contiguous aligned stereocenters, three of which are quaternary. Its structure was elucidated by extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction.

Long-Term Outcomes of Stenting for Pulsatile Tinnitus Caused by Cerebral Venous Sinus Stenosis.

Objective: To investigate the long-term outcomes of stenting for isolated pulsatile tinnitus (PT) caused by cerebral venous sinus stenosis.

Study Design: Retrospective study.

Setting: The First Medical Center, Chinese PLA General Hospital.

TOR balances plant growth and cold tolerance by orchestrating amino acid-derived metabolism in tomato.

The target of rapamycin (TOR) kinase is a central signaling hub that plays a crucial role in precisely orchestrating plant growth, development, and stress responses. This suggests that TOR is intricately involved in maintaining the balance between plant growth and stress responses. Nevertheless, despite the observed effects, the specific mechanisms through which TOR operates in these processes remain obscure.

Unveiling the role of TGF-β signaling pathway in breast cancer prognosis and immunotherapy.

Introduction: The TGF-β signaling pathway (TSP) is pivotal in tumor progression. Nonetheless, the connection between genes associated with the TSP and the clinical outcomes of breast cancer, as well as their impact on the tumor microenvironment and immunotherapeutic responses, remains elusive.

Methods: Breast cancer transcriptomic and single-cell sequencing data were obtained from the The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases.

Full-length transcriptome-referenced analysis reveals developmental and olfactory regulatory genes in Dermestes frischii.

Dermestes frischii Kugelann, 1792 is a storage pest worldwide, and is important for estimating the postmortem interval in forensic entomology. However, because of the lack of transcriptome and genome resources, population genetics and biological control studies on D. frischii have been hindered.

Investigation of Sn Promoter on Ni/CeO Catalysts for Enhanced Acetylene Semihydrogenation to Ethylene.

Ethylene, as an important chemical raw material, could be produced through the coal-based acetylene hydrogenation route. Nickel-based catalysts demonstrate significant activity in the semihydrogenation reaction of acetylene, but they encounter challenges related to catalyst deactivation and overhydrogenation. Herein, the effect of Sn promoter on Ni/CeO catalysts has been comprehensively explored for acetylene semihydrogenation.