Enhancing Outcome Prediction in Intracerebral Hemorrhage Through Deep Learning: A Retrospective Multicenter Study.

Rationale And Objectives: This study aimed to employ deep learning techniques to analyze and validate an automatic prognostic biomarker for predicting outcomes following intracerebral hemorrhage (ICH).

Materials And Methods: This study included patients with ICH whose onset-to-imaging time (OIT) was less than 6 h. Patients were randomly divided into training and test sets at a 7:3 ratio.

Gray matter morphometric biomarkers for distinguishing manganese-exposed welders from healthy adults revealed by source-based morphometry.

Background: Chronic overexposure to manganese (Mn) may result in neurotoxicity, which is characterized by motor and cognitive dysfunctions. This study aimed to utilize multivariate source-based morphometry (SBM) to explore the biomarkers for distinguishing Mn-exposed welders from healthy controls (HCs).

Methods: High-quality 3D T1-weighted MRI scans were obtained from 45 Mn-exposed full-time welders and 33 age-matched HCs in this study.

Perihematomal edema-based CT-radiomics model to predict functional outcome in patients with intracerebral hemorrhage.

Purpose: The purpose of this study was to identify possible association between noncontrast computed tomography (NCCT)-based radiomics features of perihematomal edema (PHE) and poor functional outcome at 90 days after intracerebral hemorrhage (ICH) and to develop a NCCT-based radiomics-clinical nomogram to predict 90-day functional outcomes in patients with ICH.

Materials And Methods: In this multicenter retrospective study, 107 radiomics features were extracted from 1098 NCCT examinations obtained in 1098 patients with ICH. There were 652 men and 446 women with a mean age of 60 ± 12 (SD) years (range: 23-95 years).

Insulated Interlaced Surface Electrodes for Bacterial Inactivation and Detachment.

Effective and stable antibiofouling surfaces and interfaces have long been of research interest. In this study, we designed, fabricated, and evaluated a surface coated with insulated interlaced electrodes for bacterial fouling reduction. The electrodes were printed Ag filaments of 100 μm width and 400 μm spacing over an area of 2 × 2 cm.

Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.

Ethnopharmacological Relevance: Yi-Shen-Xie-Zhuo formula (YSXZF) is a traditional Chinese medicine prescription developed from the classic prescription Mulizexie powder documented in the book of Golden Chamber Synopsis and the Buyanghuanwu Decoction recorded in the book of Correction of Errors in Medical Classics. According to our years of clinical experience, YSXZF can effectively improve qi deficiency and blood stasis in kidney disease. However, its mechanisms need further clarification.

Yishen Xiezhuo formula ameliorates the development of cisplatin-induced acute kidney injury by attenuating renal tubular epithelial cell senescence.

Background: Although cisplatin (DDP) is an important clinical anti-tumor drug, its use is limited by its nephrotoxicity. How to avoid the renal injury incurred by platinum drugs and improve the clinical efficiency of platinum drugs use has become an urgent clinical problem. Previous studies have verified that Chinese medicine has definite effects on acute kidney injury (AKI).

Radiomics for prediction of intracerebral hemorrhage outcomes: A retrospective multicenter study.

Background: Accurate risk stratification of patients with intracerebral hemorrhage (ICH) could help refine adjuvant therapy selection and better understand the clinical course. We aimed to evaluate the value of radiomics features from hematomal and perihematomal edema areas for prognosis prediction and to develop a model combining clinical and radiomic features for accurate outcome prediction of patients with ICH.

Methods: This multicenter study enrolled patients with ICH from January 2016 to November 2021.

Altered functional connectivity in emotional subregions of the anterior cingulate cortex in young and middle-aged patients with major depressive disorder: A resting-state fMRI study.

Background: It has been demonstrated that the anterior cingulate cortex (ACC) has three subregions, involved in behavior, cognition, and emotion. However, the intrinsic connectivity of the ACC subregions in patients with major depressive disorder (MDD) is still unclear. In this study, functional magnetic resonance imaging (fMRI) data was used to detect the functional connectivity (FC) of ACC subregions and the correlation with the disease severity in young and middle-aged patients with MDD.

Gray matter microstructural alterations in manganese-exposed welders: a preliminary neuroimaging study.

Objectives: Chronic occupational manganese (Mn) exposure is characterized by motor and cognitive dysfunction. This study aimed to investigate structural abnormalities in Mn-exposed welders compared to healthy controls (HCs).

Methods: Thirty-five HCs and forty Mn-exposed welders underwent magnetic resonance imaging (MRI) scans in this study.

Development and Validation of a Clinical-Based Signature to Predict the 90-Day Functional Outcome for Spontaneous Intracerebral Hemorrhage.

We aimed to develop and validate an objective and easy-to-use model for identifying patients with spontaneous intracerebral hemorrhage (ICH) who have a poor 90-day prognosis. This three-center retrospective study included a large cohort of 1,122 patients with ICH who presented within 6 h of symptom onset [training cohort, = 835; internal validation cohort, = 201; external validation cohort (center 2 and 3), = 86]. We collected the patients' baseline clinical, radiological, and laboratory data as well as the 90-day functional outcomes.

Cystic teratoma of the parotid gland: A case report.

Background: Teratoma is a common tumor, but rarely occurs in the parotid region. Only nine cases have been reported in the current literature. Although it is generally detected in infancy or childhood, it is commonly asymptomatic.

[Biodegradation of Algae-derived Organic Matter (I-DOM) from Lake Taihu].

A large amount of intracellular dissolved organic matter (I-DOM) is released during the senescent phase of phytoplankton cultures. This research investigated the bio-incubation of I-DOM of cyanobacteria in Lake Taihu under various temperatures (20, 25, and 30℃) and I-DOM initial concentrations (5, 10, and 20 mg·L) with the aid of ultraviolet-visible spectroscopy (UV-Vis) and three-dimensional fluorescence matrix-parallel factor (EEM-PARAFAC). I-DOM was effectively degraded during the incubation.

Clinical Analysis of 25 COVID-19 Infections in Children.

Background: To describe the characteristics of clinical manifestations of children with 2019 novel coronavirus (2019-nCoV) infection in Chongqing.

Methods: All 25 children with laboratory-confirmed 2019-nCoV infection by real-time reverse transcription-PCR (RNA-PCR) were admitted from the 4 designated treatment hospitals of 2019-nCoV in Chongqing from January 19 to March 12, 2020. Clinical data and epidemiologic history of these patients were retrospectively collected and analyzed.

Plain Computed Tomography With Spectral Imaging Findings of Early Cerebral Ischemia.

Purpose: To investigate the findings of plain spectral computed tomography (CT) with multiparameter of early cerebral ischemia.

Patients And Methods: Thirty-three patients with suspected early cerebral ischemia who received a one-stop CT examination (plain scan with spectral CT imaging mode, CTP and CTA) of the brain were enrolled in this study. No clear lesion was observed in any patient on the plain CT.

Clinical value of spectral CT imaging combined with AFP in identifying liver cancer and hepatic focal nodular hyperplasia.

Purpose: To investigate the clinical value of spectral computed tomography (CT) imaging combined with alpha-fetoprotein (AFP) in identifying liver cancer and hepatic focal nodular hyperplasia (FNH).

Methods: A total of 132 patients with local liver space-occupying lesions, including 68 patients with liver cancer, were randomly enrolled. All the patients underwent spectral CT imaging and AFP examinations.

Composition of dissolved organic matter controls interactions with La and Al ions: Implications for phosphorus immobilization in eutrophic lakes.

Applications of aluminium (Al) salt or lanthanum (La) modified bentonite (LMB) have become popular methodologies for immobilizing phosphorus (P) in eutrophic lakes. The presence of humic substances, has been shown to inhibit this form of treatment due to the complexation with La/Al. However, the effects of other dissolved organic matter (DOM), especially that derived from phytoplankton (the dominant source in eutrophic lakes) are unknown.

Protective Effects of Epifriedelinol in a Rat Model of Traumatic Brain Injury Assessed with Histological and Hematological Markers.

Background: This study evaluated the protective effects of epifriedelinol (EFD) in a rat model of traumatic brain injury (TBI).

Methodology: TBI was induced by dropping a weight from a specific height. The animals were separated into control, TBI, and EFD 100 and 200 mg/kg groups.

Interlaced CNT Electrodes for Bacterial Fouling Reduction of Microfiltration Membranes.

Interlaced carbon nanotube electrodes (ICE) were prepared by vacuum filtering a well-dispersed carbon nanotube-Nafion solution through a laser-cut acrylic stencil onto a commercial polyvinylidene fluoride (PVDF) microfiltration (MF) membrane. Dead-end filtration was carried out using 10 and 10 CFU mL Pseudomonas fluorescens to study the effects of the electrochemically active ICE on bacterial density and morphology, as well as to evaluate the bacterial fouling trend and backwash (BW) efficacy, respectively. Finally, a simplified COMSOL model of the ICE electric field was used to help elucidate the antifouling mechanism in solution.

Tuning electric field aligned CNT architectures via chemistry, morphology, and sonication from micro to macroscopic scale.

Electric-field alignment of carbon nanotubes (CNT) is widely used to produce composite materials with anisotropic mechanical, electrical, and optical properties. Nevertheless, consistent results are difficult to achieve, and even under identical electric field conditions the resulting aligned morphologies can vary over μm to cm length scales. In order to improve reproducibility, this study addresses (1) how solution processing steps (oxidation, sonication) affect CNT properties, and (2) how CNT chemistry, morphology, and dispersion influence alignment.

A Single-Use Paper-Shaped Microbial Fuel Cell for Rapid Aqueous Biosensing.

The traditional chamber-based microbial fuel cell (MFC) often has the disadvantages of high ohmic resistance, large volume requirements, and delayed start-up. In this study, paper-shaped MFCs utilizing a porous carbon anode, a solid Ag2 O-coated carbon cathode, and a micrometer-thin porous polyvinylidene fluoride (PVDF) separator are investigated to address the classical MFC issues. The Ag2 O-coated cathode has a low overpotential of 0.

Semiquantitative Performance and Mechanism Evaluation of Carbon Nanomaterials as Cathode Coatings for Microbial Fouling Reduction.

In this study, we examine bacterial attachment and survival on a titanium (Ti) cathode coated with various carbon nanomaterials (CNM): pristine carbon nanotubes (CNT), oxidized carbon nanotubes (O-CNT), oxidized-annealed carbon nanotubes (OA-CNT), carbon black (CB), and reduced graphene oxide (rGO). The carbon nanomaterials were dispersed in an isopropyl alcohol-Nafion solution and were then used to dip-coat a Ti substrate. Pseudomonas fluorescens was selected as the representative bacterium for environmental biofouling.