MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway.

The involvement of B lymphocytes in the pathogenesis of rheumatoid arthritis (RA) is well-established, with their early and aberrant activation being a crucial factor. However, the mechanisms underlying this abnormal activation in RA remain incompletely understood. In this study, we identified a significant reduction in MAPK4 expression in both RA patients and collagen-induced arthritis (CIA) mouse models, which correlates with disrupted B cell activation.

Tick-borne encephalitis vaccine uptake, effectiveness, and impact in Sweden from 2018 to 2022.

Tick-borne encephalitis (TBE) is an increasing health threat in Sweden and elsewhere in Europe. TBE vaccination is commonly recommended in Sweden, but limited data are available on uptake, effectiveness, and impact of TBE vaccination. General population surveys conducted in 2019-2022 were used to estimated TBE vaccine uptake.

A nucleocapsid monoclonal antibody based sandwich ELISA for the general detection of both PRRSV-2 and PRRSV-1.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failure in sows and respiratory disease in growing pigs, leading to significant economic losses worldwide. Due to the constant mutation and recombination, PRRSV exhibits significant genetic diversity, the general detection of all PRRSV-2 and PRRSV-1 strains is thus needed. In our study, four monoclonal antibodies (mAbs) against PRRSV nucleocapsid (N) protein were generated and the precise and novel B cell epitopes (KPHF and HHTVR) were identified.

Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone-A real-world study.

Background: Allergic rhinitis (AR) multimorbidity may need to be considered a specific disease because of distinct clinical and immunological differences from AR alone. Allergic multimorbidity often involves polysensitization, where allergen-specific immunoglobulin E (IgE) plays a significant role.

Objective: This study aims to explore differences in allergen IgE sensitization patterns between AR alone and AR multimorbidity.

Fe, N-CQDs triggered the fabrication of alginate encapsulated g-CN hydrogel for efficient photocatalytic activation of PMS and antibiotic degradation.

Carbon dots (CDs) mediated g-CN (CN) is a promising visible-light-driven semiconductor in catalyzing peroxymonosulfate (PMS) for aqueous contaminants remediation. However, the poor dispersibility of powered catalyst and its challenging recyclability impede their broader application. Herein, we embedded FeN bridge within the g-CN framework and immobilized g-CN gel beads (CA/FNCCN) through a 3D cross-linking process with sodium alginate.

Pathway analysis of the impact of dysphagia on the prognosis of patients with stroke: Based on structural equation modeling.

Background And Aims: Dysphagia is significantly correlated with prognostic outcomes in patients with stroke; however, the intrinsic mechanism of action between the two remains unclear. This study aimed to model the intrinsic mechanism of action between dysphagia and prognostic outcomes in patients with stroke based on structural equation modeling.

Methods: A retrospective analysis of 900 inpatients with stroke from three large hospitals was performed.

Cross-sectional and prospective associations between children's eating behavior and visceral fat area and trunk fat mass.

Background: Understanding children's eating behaviors is crucial for elucidating the etiology of childhood obesity. However, the relationship between these behaviors and abdominal fat accumulation remains poorly understood. This study aims to investigate this association in primary school children.

Advanced Biologic Therapies in the Management of Asthma in Children and Adolescents: A Comprehensive Network Meta-Analysis.

Introduction: Emerging evidence has underscored the positive impact of biologics on asthmatic patients. However, there is a pressing need to verify their therapeutic efficacy in children and adolescents with asthma. To address this, we conducted a network meta-analysis (NMA) to evaluate the efficacy and safety of biologics in the asthma management of this demographic.

Self-amplifying mRNA vaccines protect elderly BALB/c mice against a lethal respiratory syncytial virus infection.

Respiratory syncytial virus (RSV) represents a significant threat, being a primary cause of critical lower respiratory tract infections and fatalities among infants and the elderly worldwide, and poses a challenge to global public health. This urgent public health challenge necessitates the swift development of safe and effective vaccines capable of eliciting robust immune responses at low doses. Addressing this need, our study investigated five self-amplifying mRNA (sa-mRNA) candidate vaccines that encode the various pre-fusion conformations of the RSV fusion protein.

Neural and gaze pattern responses to happy faces in autism: Predictors of adaptive difficulties and re-evaluation of the social motivation hypothesis.

Background: The "Social Motivation" hypothesis posits that social deficits in autism spectrum disorder (ASD) arise from altered reward perception. However, few studies have examined neural and behavioral responses to social reward-related cues in low functioning ASD children with limited cognitive or language abilities.

Objective: This study investigated if young children with ASD show atypical gaze towards happy faces and its association with altered brain reward responses.

Clinical features and genetic analysis of 471 cases of fetal congenital heart disease.

Background: Congenital heart disease (CHD) is a heterogeneous collection of structural abnormalities of the heart or great vessels that are present at birth. These birth defects are one of the leading causes of infant mortality and morbidity worldwide. The etiology and pathogenesis of CHD are unclear and largely considered to be multifactorial in nature.

Diabetic Peripheral Neuropathy and Glycemia Risk Index in Type 2 Diabetes: A Cross-Sectional Study.

Purpose: Diabetic peripheral neuropathy (DPN) is a prevalent chronic complication of diabetes which is linked to chronic hyperglycemia and glycemic variability. This study aimed to investigate the association between the glycemia risk index (GRI) and DPN in patients with type 2 diabetes mellitus (T2DM) using continuous glucose monitoring (CGM) data.

Patients And Methods: From 2019 to 2023, 862 adults diagnosed with T2DM were enrolled at a tertiary care diabetes center in Ningbo, China.

Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus.

Background: Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to investigate SLE-pathogenic gut microbes and their potential mechanisms.

Methods: There were 134 healthy controls (HCs) and 114 SLE cases for 16 S ribosomal RNA (rRNA) sequencing and 97 HCs and 124 SLE cases for shotgun metagenomics.

[Clinical Crrelation and Prognostic Analysis of ALBI Score in Secondary Hemophagocytic Syndrome in Children].

Objective: To explore the clinical correlation and prognostic value of the Albumin-Bilirubin (ALBI) score in children with secondary hemophagocytic syndrome(sHLH).

Methods: A retrospective analysis was conducted on the data of children's sHLH cases clearly diagnosed in the Affiliated Hospital of Zunyi Medical University from January 2012 to March 2023. Survival analysis was conducted according to the ALBI classification.

[The Effects of on the Proliferation and Apoptosis of Acute Myeloid Leukemia THP-1 Cells].

Objective: To discover the relationship between the gene and acute myeloid leukemia (AML), and explore the effect of on the proliferation and apoptosis of THP-1 cells.

Methods: Analyze the expression of gene in AML and its relationship with prognosis through the GEPIA database. Collecting 30 AML patients and non-tumor hematological patients who went to the Affiliated Hospital of Zunyi Medical University from January 2017 to January 2022.

Clinical characteristics and prognostic analysis of pediatric hemophagocytic lymphohistiocytosis using lasso-logistic regression.

This study aims to evaluate and predict mortality risks among pediatric patients with hemophagocytic lymphohistiocytosis (HLH). We conducted a retrospective analysis of pediatric patients with HLH diagnosed at the Affiliated Hospital of Zunyi Medical University between January 2012 and April 2023. Patients were divided into a death group and a survival group based on their outcomes.

Boosting lactic acid photocatalytic synthesis from biomass sugars: The synergistic effect of N-doped carbon dots on ultrathin carbon nitride.

The green and sustainable production of lactic acid via photocatalytic conversion of biomass-derived sugars is highly significant owing to its enhanced efficiency and reduced energy requirements. Consequently, the investigation has engineered a metal-free photocatalyst (NCDs/CCN), consisting of N-doped carbon dots (NCDs) and ultrathin carbon nitride (CCN). This catalyst has an enhanced light absorption range, facilitating a marked acceleration in the separation rate of photogenerated carriers.

PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma.

Progranulin (PGRN) plays a critical role in bronchial asthma and the function of various immune cells. However, the mechanisms by which PGRN influences B-cell receptor (BCR) signaling and immunoglobulin E(IgE) production are not fully understood. The study aimed to elucidate the molecular mechanisms through which PGRN affects BCR signaling, B-cell differentiation, and IgE production.

Assessing the impact of various irrigation technologies on agricultural production: A water-energy‑carbon nexus perspective.

Effective coordination of water, energy, and carbon is vital for the sustainable development of irrigated agriculture. However, limited research has been conducted on the impact of irrigation technology on the coupling and coordination relationship of these elements, especially on the North China Plain (NCP) where irrigation is applied extensively. This study establishes a water-energy‑carbon (WEC) nexus framework based on footprint theory and energy analysis.

Enterovibrio qingdaonensis sp. nov. and Enterovibrio gelatinilyticus sp. nov., two marine bacteria isolated from surface seawater of Qingdao offshore.

Two Gram-stain-negative, facultatively anaerobic, motile, and rod-shaped marine bacteria, designated strains ZSDZ35 and ZSDZ42, were isolated from surface seawater of Qingdao offshore. Phylogenetic analysis of the 16S rRNA genes and whole genome data placed ZSDZ35 and ZSDZ42 within the genus Enterovibrio. Strain ZSDZ35 was most closely related to Enterovibrio nigricans DSM 22720 with 97.