Seasonal fluctuation of total water intake and hydration status among young men and women: a prospective cohort study.

Background: Water intake and hydration status have been reported to fluctuate throughout the year. This study investigated seasonal fluctuations of total water intake and hydration status among young adults in Baoding, China.

Methods: This prospective cohort study enrolled 82 young adults aged 18-23 years in Baoding, China.

Selective A-Site Exsolution and Phase Transition in Perovskite Electrode for Efficient Flexible Znic-Air Batteries.

Zinc-air batteries (ZABs) are highly promising for flexible electronics due to their high energy density and cost-effective. However, their practical application is impeded by the sluggish kinetics of the oxygen evolution and oxygen reduction reactions (OER/ORR). This study presents a novel design featuring BaO nanoparticles anchored on layered perovskite PrBaMnCoO (PBMC) nanofibers, fabricated through a plasma method.

Differences in anti-obesity effects between raw and ripened Pu-erh tea polyphenols: impact on gut microbiota enterotypes.

Background: Pu-erh tea, a dark tea from China, is classified into raw and ripened types. Both have significant anti-obesity effects. Polyphenols are among their major bioactive components.

Diagnostic and discriminative accuracy of plasma phosphorylated tau 217 for symptomatic Alzheimer's disease in a Chinese cohort.

Background: Plasma phosphorylated tau at threonine 217 (p-tau217) measured with an ultrasensitive immunoassay method has been demonstrated to be an optimal biomarker for Alzheimer's disease (AD).

Objectives: The aim of this study was to establish the reference interval for plasma p-tau217 in Chinese individuals and evaluate its diagnostic value in symptomatic AD.

Design, Setting, Participants: We recruited 150 cognitively unimpaired (CU) individuals, 60 patients with AD dementia, 30 patients with mild cognitive impairment (MCI) due to AD, 40 patients with frontotemporal lobar degeneration (FTLD), and 70 patients with subcortical ischaemic vascular dementia (SIVD).

Dynamic changes in the gut microbiota play a critical role in age-associated cognitive dysfunction via SCFAs and LPS synthesis metabolic pathways during brain aging.

Background: Gut microbiota plays an essential role in cognitive dysfunction during aging. The aim of this study was to investigate the dynamic alterations in the gut microbiota and screen for key gut bacterial taxa correlated with age-associated cognitive dysfunction during natural aging.

Methods: 16S rRNA gene sequencing was performed to determine the composition of the gut microbiota in faecal samples from SAMR1 and SAMP8 mice, cognitively normal controls (NC), and patients with amnestic mild cognitive impairment (aMCI).

Interaction of rice glutelin with soybean 7S globulin formed co-assemblies with improved functional properties.

Rice protein (RP) molecules tend to aggregate, limiting their functional properties and posing a significant challenge to the intensive processing of rice products. This study explored the interaction between soybean 7S globulin (7S) and rice glutelin (RG) to improve the structure and properties of RP. The results show that the tertiary structure of the RG-7S co-assemblies undergoes a certain degree of extension, increases the α-helix content, and reduces the β-sheet content in the secondary structure.

Causal Machine Learning for Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation.

Background: Transcatheter left atrial appendage occlusion (LAAO) is an alternative to lifelong anticoagulation, but optimal patient selection remains challenging.

Objectives: This study sought to apply a novel causal machine learning framework to identify patients who would benefit from LAAO vs a direct oral anticoagulant (DOAC).

Methods: We identified 744,190 adult patients with atrial fibrillation treated with either LAAO or DOAC between March 13, 2015, and December 31, 2019, using data from OptumLabs Data Warehouse.

Development of A Caregiver-Reported Scale for Pediatric Cancer Financial Toxicity (CRS-PCFT).

Background: Financial toxicity is common among families of pediatric patients with cancer. However, the availability of survey and/or screening instruments specific to pediatric family financial toxicity is limited.

Methods: A two-round cross-sectional survey was conducted in Shandong Province, China.

[Determination of diazepam and its three metabolites in fish by pass-through solid phase extraction purification combined with ultra-performance liquid chromatography-tandem mass spectrometry].

Objective: A stable isotope dilution-through solid phase extraction(SPE)-ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method was established for rapid determination of diazepam and its three metabolites(nordiazepam, temazepam and oxazepam) in fish.

Methods: Sample was extracted with acetonitrile, then salted out with sodium chloride and degreased by freezing centrifugation. The acetonitrile layer diluted to a ratio of 90 percents with pure water, and through C_(18)/PSA SPE column for purification.

Lightweight UAV Landing Model Based on Visual Positioning.

In order to enhance the precision of UAV (unmanned aerial vehicle) landings and realize the convenient and rapid deployment of the model to the mobile terminal, this study proposes a Land-YOLO lightweight UAV-guided landing algorithm based on the YOLOv8 n model. Firstly, GhostConv replaces standard convolutions in the backbone network, leveraging existing feature maps to create additional "ghost" feature maps via low-cost linear transformations, thereby lightening the network structure. Additionally, the CSP structure of the neck network is enhanced by incorporating the PartialConv structure.

Network Flow Method Integrates Skeleton Information for Multiple Tracking.

In order to solve the issues arising from collisions, this paper proposes a network flow method combined with skeleton information for multiple tracking. In the intra-track stage, non-colliding are identified and associated as trajectory fragments based on their motion and positional information, and colliding are then segmented based on an improved skeleton algorithm and matched as trajectory fragments. Subsequently, the trajectory fragments are employed as vertices to construct a network flow model.

Multiprotein Complexes of Plant Glycosyltransferases Involved in Their Function and Trafficking.

Plant cells utilize protein oligomerization for their functions in numerous important cellular processes. Protein-protein interactions are necessary to stabilize, optimize, and activate enzymes, as well as localize proteins to specific organelles and membranes. Glycosyltransferases-enzymes that attach sugars to polysaccharides, proteins, lipids, and RNA-across multiple plant biosynthetic processes have been demonstrated to interact with one another.

Isolation and Characterisation of Acid Soluble Collagens and Pepsin Soluble Collagens from Eel ( Temminck et Schlegel) Skin and Bone.

Eel () is an important and valuable food fish in East Asia and its by-products have been reported to include bioactive and profitable components. This study aimed to extract, characterise, and compare the structure and properties of acid-soluble collagens (ASCs) and pepsin-soluble collagens (PSCs) from the skin and bone of eel (), providing insights into their composition, structure, and properties for various applications. The yields of ASC-S (from skin), PSC-S (from skin), ASC-B (from bone), and PSC-B (from bone) were 12.

Application of Smart Packaging in Fruit and Vegetable Preservation: A Review.

The application of smart packaging technology in fruit and vegetable preservation has shown significant potential with the ongoing advancement of science and technology. Smart packaging leverages advanced sensors, smart materials, and Internet of Things (IoT) technologies to monitor and regulate the storage environment of fruits and vegetables in real time. This approach effectively extends shelf life, enhances food safety, and reduces food waste.

Lacticaseibacillus casei JS-2 from 'Jiangshui' Reduces Uric Acid and Modulates Gut Microbiota in Hyperuricemia.

Lacticaseibacillus casei (JS-2) is a novel probiotic isolated from "Jiangshui", a kind of traditional folk fermented food, which has a significant effect on hyperuricemia (HUA). In vitro experimental results showed that JS-2 has a high degradation ability and selectivity for uric acid (UA). The animal test results indicated that after two weeks of treatment, JS-2 could significantly reduce the level of UA in the serum of HUA quails ( < 0.

Integrated Transcriptomics and Metabolomics Analysis Reveals Convergent and Divergent Key Molecular Networks of Dominant Genic Male Sterility and Cytoplasmic Male Sterility in Cabbage.

Cytoplasmic male sterility (CMS) and dominant genic male sterility (DGMS) both result in the inability to produce or release functional pollen, making them pivotal systems in the hybridization breeding programs of crops such as cabbage ( var. ). However, the underling molecular mechanisms are still largely unexplored.

Optimization of CRISPR/Cas9 Gene Editing System in Sheep () Oocytes via Microinjection.

The CRISPR/Cas9 system has become a powerful tool for molecular design breeding in livestock such as sheep. However, the efficiency of the Cas9 system combined with zygote microinjection remains suboptimal. In this study, mature sheep oocytes were used for microinjection to assess the impact of various factors on Cas9 editing efficiency.

Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database.

Background: Sepsis is a serious consequence of acute pancreatitis (AP) that requires immediate detection and treatment. Triglyceride-glucose (TyG) index demonstrated predictive ability for a number of diseases. In an effort to enhance clinical care and early warning systems, this study examined the association between the TyG index and sepsis risk with the aim of improving clinical care and early warning systems.

Infant Kawasaki disease complicated with supraventricular tachycardia: a case report and literature review.

Background: The occurrence of arrhythmias as a complication of Kawasaki disease (KD) is extremely rare. Moreover, previous literature showed a low incidence of arrhythmias during the acute phase of KD, and the majority occurred in the subacute and chronic phases. To date, we have found only 17 sporadically reported global cases in the available literature.

[A case of corneal and conjunctival damage caused by suture exposure after buried-suture clouble-eyelid blepharoplasty].

A 52-year-old female patient experienced red eyes and eye pain for more than one year due to suture exposure in the left eye after double eyelid plasty with the embedding suture method. She visited several hospitals outside and was diagnosed with keratitis and conjunctival mass in the left eye. After anti-inflammatory and anti-infection treatments, the condition relapsed.

Synthetic tunable promoters for flexible control of multi-gene expression in mammalian cells.

Introduction: Synthetic biology revolutionizes our ability to decode and recode genetic systems. The capability to reconstruct and flexibly manipulate multi-gene systems is critical for understanding cellular behaviors and has significant applications in therapeutics.

Objectives: This study aims to construct a diverse library of synthetic tunable promoters (STPs) to enable flexible control of multi-gene expression in mammalian cells.

Melanoma in older adolescents and young adult patients: A population-based analysis of the Surveillance, Epidemiology, and End Results Program database from 2000 to 2019.

Epidemiologic characteristics of melanoma in older adolescents and young adult (AYA) patients aged 15 to 39 years are unknown. We examined the epidemiologic characteristics of melanoma in AYA patients and then extracted demographic and pathologic data for this retrospective cohort study from the Surveillance, Epidemiology, and End Results database (2000-2019). Cox regression analyses were used to assess the risk of all-cause death, cancer-specific death, and second primary malignancy.

Long-Term Effect of Intelligent Virtual Reality First-Aid Training on Cardiopulmonary Resuscitation Skill Proficiency.

Objectives: To explore the long-term effect of intelligent first-aid training based on virtual reality (VR) technology on cardiopulmonary resuscitation (CPR) skill proficiency.

Methods: The convenience sampling method was used to select a total of 100 non-medical volunteers from Nanchang, China, and this cohort was randomized to either the VR training group (VR group) or the traditional simulation scenario training group (traditional group). Relevant data were collected for comparative analysis.

Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.

Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.

Objective: Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.

Changes in drinking levels and metabolic dysfunction-associated steatotic liver disease: a longitudinal study from the China multi-ethnic cohort study.

Background: Little is known about the associations of changes in drinking levels with the newly defined metabolic dysfunction-associated steatotic liver disease (MASLD). We therefore sought to estimate the associations between changes in drinking levels and MASLD in less developed regions of China.

Methods: This longitudinal study included 8727 participants from the China Multi-Ethnic Cohort (CMEC) in less developed regions, all participating in baseline and a follow-up survey.