Seasonal lake ice cover drives the restructuring of bacteria-archaea and bacteria-fungi interdomain ecological networks across diverse habitats.

The coexistence of different microbial communities is fundamental to the sustainability of many ecosystems, yet our understanding of the relationships among microbial communities in plateau cold-region lakes affected by seasonal ice cover remains limited. This research involved investigating three lakes in the Inner Mongolia segment of the Yellow River basin during frozen and unfrozen periods in two habitats: water bodies and sediments. The research examined the composition and function of bacteria, archaea, and fungi across different times and habitats within the basin, their response to environmental variables in water and sediment, and inter-domain interactions between bacteria-archaea and bacteria-fungi were compared using interdomain ecological network (IDEN).

Correlations of the expression of Cx43, SCF, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues.

Background: Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination. Conversely, reduced expression results in a loss of this capacity to facilitate cyclin E degradation. The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein, with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues

Aim: To investigate the correlation between expression of Cx43, SKP1/Cullin1/F-box (SCF), p-cyclin E1 (ser73, thr77, thr395) and clinicopathological indexes in colon cancer.

LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice.

Colorectal cancer (CRC) is one of the malignant tumors globally, with high morbidity and mortality rates. The mainstay treatment of CRC includes surgery, radiotherapy, and chemotherapy. However, these treatments are associated with a high recurrence rate, poor prognosis, and highly toxic side effects.

Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study.

This study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002-2019) of the English Longitudinal Study of Aging. A latent class analysis was used to identify patterns of physical multimorbidity, and mixed multilevel models were performed to determine the association between physical multimorbidity and trajectories of cognitive decline.

Preparation of porous carbon derived from a lignin-based polymer through ZnCl activation for effective capture of iodine.

Lignin-based porous carbon, a derivative of lignin, is acknowledged for its cost-effectiveness, stability, and environmental sustainability. It exhibits significant adsorption capacity for the removal of heavy metals and in wastewater treatment, rendering it a highly esteemed adsorbent material. However, the potential of lignin-derived porous carbon for the capture of iodine in environmental contexts has yet to be thoroughly investigated.

MiR8523 negatively regulates the immunity of Plutella xylostella against entomopathogenic fungus Isaria cicadae by targeting PxSpz5.

The diamondback moth, Plutella xylostella is a notorious pest and has developed serious resistance to insecticides. Entomopathogenic fungi (EPF) have been developed as eco-friendly alternatives to insecticides. Insects rely on their immunity to defend against fungi.

The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials.

Digital technology interventions (DTIs) are seen as promising interventions to prevent or delay cognitive decline in older adults, yet evidence from reviews is not conclusive. The aim of this study is to explore the effectiveness of DTIs in improving older adults' cognitive function while taking study design and intervention characteristics as moderators. We searched the PubMed, Embase, CINAHL, PsycINFO, and Scopus databases up to May 26, 2023.

Unveiling van Hove Singularity-Boosted Photothermoelectric Response for Wearable Human-Radiation Detection.

Van Hove singularity (vHs), the singularity point of density of states (DOS) in crystalline solids, is a research hotspot in emerging phenomena such as light-matter interaction, superconducting, and quantum anomalous Hall effect. Although the significance of vHs in photothermoelectric (PTE) effect has been recognized, its integral role in electron excitation and thermoelectric effect is still unclear, particularly in the mid-infrared band that suffers from Pauli blockade in semimetals. Here, we unveil the Fermi-level-modulated PTE behavior in the vicinity of vHs in carbon nanotubes, employing ionic-liquid gating.

Associations of PFAS concentrations during pregnancy and midlife with bone health in midlife: Cross-sectional and prospective findings from Project Viva.

Background: PFAS may impair bone health, but effects of PFAS exposure assessed during pregnancy and the perimenopause-life stages marked by rapidly changing bone metabolism-on later life bone health are unknown.

Methods: We studied 531 women in the Boston-area Project Viva cohort. We used multivariable linear, generalized additive, and mixture models to examine associations of plasma PFAS concentrations during early pregnancy [median (IQR) maternal age 32.

0-Dimensional/1-dimensional S-scheme AgS/BiSI hetero-structured photocatalyst for superb Cr(VI) reduction under full spectrum irradiation.

Developing ultraviolet (UV), visible (Vis) and near-infrared (NIR) responsive photocatalysts for Cr(VI) reduction is valuable. Herein, a 0-dimensional/1-dimensional (0D/1D) S-scheme AgS/BiSI hetero-structured photocatalyst was successfully synthesized, which displays greatly enhanced Cr(VI) removal activity either under UV, Vis or NIR light irradiation. In-situ characterization technique and theoretical calculation confirm that an internal electric field (IEF), directing from AgS to BiSI, exists between the interface, which facilitates the spatial-oriented separation of photoirradiated carriers.

Lignin-based materials for iodine capture and storage: A review.

The safety of nuclear energy, as a low-carbon energy source, has received widespread attention. One of the concerns is the appropriate handling of volatile radioactive elements (e.g.

Orthostatic and Standing Hypertension and Risk of Cardiovascular Disease.

Background: Orthostatic hypertension is an emerging risk factor for adverse events. Recent consensus statements combine an increase in blood pressure upon standing with standing hypertension, but whether these 2 components have similar risk associations with cardiovascular disease (CVD) is unknown.

Methods: The ARIC study (Atherosclerosis Risk in Communities) measured supine and standing blood pressure during visit 1 (1987-1989).

Endoscopic transsphenoidal surgery for infradiaphragmatic craniopharyngiomas and impact of diaphragm sellae competence on hypothalamic injury.

Investigate the impact of diaphragm sellae competence on surgical outcomes and risk factors for postoperative hypothalamic injury (HI) in patients undergoing endoscopic transsphenoidal surgery (ETS) for infradiaphragmatic craniopharyngiomas (ICs). A retrospective analysis of 54 consecutive patients (2016-2023) with ICs treated by ETS was conducted. All tumors originated from the sellar region inferior to the diaphragm sellae and were classified into two subtypes in terms of diaphragm sellae competence: IC with competent diaphragm sellae (IC-CDS) and IC with incompetent diaphragm sellae (IC-IDS).

Nonlinear and synergistic effects of demographic characteristics on urban polycentric structure using SHAP.

Polycentric urban development is promoted by urban planners and policy makers for its perceived benefits of alleviating urban issues. Theoretically, a polycentric urban structure is formed when different demographic groups present a collection of diverse and unique housing location preferences. Yet, only limited empirical studies have fully captured the complex effects of demographic characteristics on urban polycentric structures.

Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort.

Background: Prenatal per- and polyfluoroalkyl substance (PFAS) exposures are associated with adverse offspring health outcomes, yet the underlying pathological mechanisms are unclear. Cord blood metabolomics can identify potentially important pathways associated with prenatal PFAS exposures, providing mechanistic insights that may help explain PFAS' long-term health effects.

Methods: The study included 590 mother-infant dyads from the Boston Birth Cohort.

Ratio type nanoprobe with boric acid as recognition unit for imaging intracellular HO with SERS.

Fluctuations of intracellular HO level are intricately linked to diverse biological processes, e.g., cellular proliferation, biosynthesis, and metabolic activities.

Fe/Cu Bimetallic Nanozyme Co-Assembled with Lu and Tanshinone for Quadruple-Synergistic Tumor-Specific Therapy.

The co-loading of radionuclides and small-molecule chemotherapeutic drugs as nanotheranostic platforms using nanozymes holds tremendous potential for imaging-guided synergistic therapy. This study presents such nanotheranostic platform (Lu-MFeCu@Tan) via co-assembling Lu radionuclide and tanshinone (Tan) into Fe/Cu dual-metal nanozyme (MFeCu). This platform simultaneously enables single-photon emission computed tomography (SPECT) imaging and a quadruple-synergistic tumor therapy approach, including internal radioisotope therapy (RIT), catalysis therapy, chemotherapy, and MFeCu-mediated ferroptosis and cuproptosis therapy.

Corrigendum: Initial experience with radiomics of carotid perivascular adipose tissue in identifying symptomatic plaque.

[This corrects the article DOI: 10.3389/fneur.2024.

Ten-Step Total Synthesis of (±)-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation.

We report an efficient total synthesis of (±)-phaeocaulisin A, a guaianolide sesquiterpene natural product possessing a complex tetracyclic skeleton embedded with an oxaspirolactone and a fused bicyclic lactone, four oxygen-containing stereocenters, and an 8-oxabicyclo[3.2.1]octane core.

Relationship between the surface and internal deformation features of toppling in anti-dip rock slopes.

Multiple researchers have effectively utilized InSAR for early identification research in southwest China. However, the intricate geological structure in this region includes deeply buried and unpredictable anti-dip stratiform rock slopes, posing an additional challenge for InSAR remote sensing. This study establishes a coupling relationship between slope topple deformation patterns and surface macro-deformation characteristics through a centrifuge model test, analyzing slope bending and topple deformation stages.

QCD challenges from pp to AA collisions: 4th edition.

This paper is a write-up of the ideas that were presented, developed and discussed at the fourth International Workshop on QCD Challenges from pp to AA, which took place in February 2023 in Padua, Italy. The goal of the workshop was to focus on some of the open questions in the field of high-energy heavy-ion physics and to stimulate the formulation of concrete suggestions for making progresses on both the experimental and theoretical sides. The paper gives a brief introduction to each topic and then summarizes the primary results.

Depressive symptoms among Chinese adolescents from single parent families present a downward trend in the past 25 years: A cross-temporal meta-analysis.

Background: In recent decades, depressive symptoms have intensified among Chinese adolescents, particularly those from single-parent homes, who are presumed to face heightened mental health risks. Nonetheless, economic growth, fertility policy reforms, and cultural openness have enhanced the adaptability of these adolescents, enabling them to better manage depressive symptom risks.

Aim And Method: This study aims to scrutinize the evolving trends of depressive symptoms and explore the related social factors among Chinese adolescents from single-parent families.