Analyzing trends in the spatial-temporal visitation patterns of mainland Chinese tourists in Sabah, Malaysia based on Weibo social big data.

Conducting on-site surveys to assess tourists' spatial visitation patterns and preferences is both time and labor intensive. However, an assessment of regional visitation patterns based on social media data can be an important decision-making tool for tourism management. In this study, an assessment of the visitation patterns of Chinese mainland tourists in Sabah is conducted to identify high-visitation hotspots and their changes, as well as large-scale and small-scale temporal characteristics.

Application of molecular imprinting polymers in separation of active compounds from plants.

Molecular imprinting technique is becoming an appealing and prominent strategy to synthesize materials for target recognition and rapid separation. In recent years, it has been applied in separation of active compounds from various plants and has achieved satisfying results. This review aims to make a brief introduction of molecular imprinting polymers and their efficient application in the separation of various active components from plants, including flavonoids, organic acids, alkaloids, phenylpropanoids, anthraquinones, phenolics, terpenes, steroids, and diketones, which will provide some clues to help stimulating research into this fascinating and useful area.

Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer.

The homologous recombination repair (HRR) pathway is critical for repairing double-strand breaks (DSB). Inhibition of the HRR pathway is usually considered a promising strategy for anticancer therapy. The Bloom's Syndrome Protein (BLM), a DNA helicase, is essential for promoting the HRR pathway.

Luteolin Attenuates Diabetic Myocardial Hypertrophy by Inhibiting Proteasome Activity.

Introduction: Luteolin is a flavonoid polyphenolic compound exerting broad pharmacological and medicinal properties. Diabetes-related obesity increases the total blood volume and cardiac output and may increase the myocardial hypertrophy progression. However, the mechanism of luteolin in diabetic myocardial hypertrophy remains uncertain.

Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application.

Dental implants are widely used to restore missing teeth because of their stability and comfort characteristics. Peri-implant infection may lead to implant failure and other profound consequences. It is believed that peri-implantitis is closely related to the formation of biofilms, which are difficult to remove once formed.

New rapid detection by using a constant temperature method for avian leukosis viruses.

The avian leukemia virus causes avian leukemia (AL), a severe immunosuppressive disease in chickens (ALV). Since the 1990s, the diversity of ALV subpopulations caused by ALV genome variation and recombination, and the complexity of the infection and transmission, with currently no effective commercial vaccine and therapeutic for ALV, has resulted in severe economic losses to the chicken business in various parts of the world. Therefore, as a key means of prevention and control, an effective, rapid, and accurate detection method is imperative.

Recombinant Muscovy Duck Parvovirus Led to Ileac Damage in Muscovy Ducklings.

Waterfowl parvovirus (WPFs) has multiple effects on the intestinal tract, but the effects of recombinant Muscovy duck parvovirus (rMDPV) have not been elucidated. In this study, 48 one-day-old Muscovy ducklings were divided into an infected group and a control group. Plasma and ileal samples were collected from both groups at 2, 4, 6, and 8 days post-infection (dpi), both six ducklings at a time.

Carboxymethyl Dextran-Based Nanomicelle Coatings on Microarc Oxidized Titanium Surface for Percutaneous Implants: Drug Release, Antibacterial Properties, and Biocompatibility.

Bacterial contamination and biofilm formation onpercutaneous implants can lead to device failure and be life-threatening. To solve this issue, we constructed a carboxymethyl dextran- (CMD-) based nanomicelle antibacterial coating on the microarc-oxidized titanium (MAO-Ti) surface (described in the supplementary file). The self-assembled CMD-based nanomicelles and octadecylamine (ODA) were developed as a drug carrier and loaded with minocycline (MC).

Evaluation and diagnosis of obstacles to land-based ecological security in resource-based cities: A case study of Xingtai city.

To provide a theoretical basis for sustainable land resource utilization and a reference for areas with similar natural conditions, an evaluation index for land-based ecological security was constructed based on the Driving force-Pressure-State-Impact-Response (DPSIR) model and the improved analytic hierarchy process (IAHP) and entropy methods, and the land-based ecological security status of Xingtai city from 2006 to 2017 was evaluated. Then, the obstacles to land-based ecological security were diagnosed. The results show that the values of the comprehensive evaluation index of land-based ecological security were 0.