Using a modified far-lateral approach to remove hypoglossal neurilemmomas: notes on technique.

Object: In this paper the authors describe a modified far-lateral transcondylar approach to remove hypoglossal neurilemmomas (HGNs).

Methods: Between September 2008 and June 2011, 11 consecutive patients with HGNs underwent tumor removal via a modified far-lateral transcondylar approach. The average age at presentation, tumor characteristics, cranial nerve (CN) deficits, and outcomes were assessed.

[Phenotype and genotype analysis of two Chinese pedigrees with type 3 von Willebrand diseases].

Objective: To analyze the phenotype and genotype of two Chinese pedigrees with von Willebrand diseases, and to investigate the molecular pathogenesis.

Methods: Bleeding time (BT), activated partial thromboplastin time (APTT), ristocetin-induced platelet aggregation (RIPA), von Willebrand factor-ristocetin cofactor (vWF:Rco), von Willebrand factor antigen (vWF:Ag), von Willebrand factor activity (vWF:A), von Willebrand factor collagen binding assay (vWF:CB) and multimer analysis were used for phenotype diagnosis. DNA was extracted.

[Phase synchronization analysis of EEG signal during audio-visual stimulation].

EEG Synchronization is considered the conformity of the brain functional areas. Advanced brain function requires many nervous systems with a specific function in relevant brain regions (areas) to achieve integration and coordination at different levels. In this paper, a new method for phase synchronization analysis-Mutually Approximate Entropy is proposed to process different frequency band of EEG signal during audio-visual stimulation and get Similar results with the method of Synchronization Index and Mutual Information Entropy.

[Prognostic value of brain natriuretic peptide in people with viral myocarditis].

Objective: To explore the brain natriuretic peptide (BNP) on prognostic value in patients with viral myocarditis.

Methods: A total of 48 patients with viral myocarditis and 42 healthy people were enrolled and followed up for two years. The NYHA class and LVEF were recorded and the concentration of BNP were measured.

Effects of erythropoietin on blood-brain barrier tight junctions in ischemia-reperfusion rats.

Administration of recombinant human erythropoietin (rhEPO) protects neurons from injury after brain ischemia-reperfusion (I/R), which is in part mediated by ameliorating the blood-brain barrier (BBB) leakage. But the mechanism of rhEPO's protective effects on BBB remains unclear. This study aims to investigate the effects of rhEPO on BBB integrity and the expressions of tight junctions (TJs) associated proteins of zonula occluden-1 (ZO-1), occludin, and claudin-5 in cerebral I/R rats.

[Relationship between single nucleotide polymorphism in repair gene XPD751 and prognosis in colorectal carcinoma patients].

Objective: To investigate whether single nucleotide polymorphism (SNP) in DNA repair gene XPD751 is associated with sensitivity and time to progression (TTP) for platinum-containing combination chemotherapy in advanced colorectal carcinoma.

Methods: A total of 98 patients pathologically diagnosed as advanced colorectal cancer were treated with FOLFOX chemotherapy. TheDNA of peripheral blood-leukocytes was obtained before treatment, and XPD genetype was detected by PCR-RFLP analysis.

[Genotype and function analyses of four inherited dysfibrinogenemia pedigree caused by Arg16 amino acid substitution in fibrinogen Aα chain].

Objective: To analyze the phenotype, genotype and function in four Chinese pedigrees with inherited dysfibrinogenemia.

Methods: Routing tests including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), reptilase time (RT), the activities of antithrombin (AT), protein C (PC) and protein S (PS) were detected in four pedigrees. The activity and antigen of plasma fibrinogen were analyzed by Clauss and immunoturbidimetry methods, respectively.

Lateral ventricular subependymomas: An analysis of the clinical features of 27 adult cases at a single institute.

Objective: To evaluate the unique clinical characteristics and management of lateral ventricular subependymomas (LVSs). Patients and Methods : The case records of 27 adult consecutive patients with LVS admitted between March 1996 and May 2011 were reviewed. The relevant clinical data (including patient age and sex, neuroimaging studies, surgical records and follow up) were collected through a chart review.

[Analysis of surgery effect on 198 cases of pulmonary echinococcosis].

Objective: To summarize the experience in the surgical treatment of pulmonary echinococcosis, and evaluate the operative approach to avoid recurrence.

Methods: A retrospective study was carried out to analyze the clinical data of 198 cases with pulmonary echinococcosis from January 2000 to October 2010 in the First Affiliated Hospital of Xinjiang Medical University, involving the general conditions, clinical course, epidemiology, clinical characteristics, therapeutic approaches and outcomes.

Results: There were 114 male and 84 female patients aged from 2 to 68 years with a mean of 25.

Inference of gene regulatory subnetworks from time course gene expression data.

Background: Identifying gene regulatory network (GRN) from time course gene expression data has attracted more and more attentions. Due to the computational complexity, most approaches for GRN reconstruction are limited on a small number of genes and low connectivity of the underlying networks. These approaches can only identify a single network for a given set of genes.

Revealing the metabonomic variation of EC using ¹H-NMR spectroscopy and its association with the clinicopathological characteristics.

In this study, (1)H NMR-based metabonomics has been applied to investigate esophageal cancer metabolic signatures in plasma and urine, purpose of assessing the diagnostic potential of this approach and gaining novel insights into esophageal cancer metabolism and systemic effects. Plasma and urine samples from esophageal cancer patients (n = 108) and a control healthy group (n = 40) were analyzed by Nuclear Magnetic Resonance (NMR) spectroscopy (600 MHz), and their spectral profiles subjected to Orthogonal Projections to Latent Structures (OPLS-DA) for multivariate statistics. Potential metabolic biomarkers were identified using data base comparisons used for examining the significance of metabolites.

Surgical treatment and long-term outcomes of thalamic cavernous malformations.

Objective: Resection of thalamic cavernous malformations (CMs) is controversial. The goals of this study were to evaluate the outcome of thalamic CMs after surgical resection, assess predictors of prognosis, and review the literature.

Methods: The authors used the modified Rankin scale (mRS) to retrospectively evaluate the presentation, surgery, and outcomes of 27 consecutive patients who underwent thalamic CMs microresection using six different approaches between 1998 and 2010.

Expression and significance of sonic hedgehog signaling pathway-related components in brainstem and supratentorial astrocytomas.

Background: Studies have shown that abnormal activation of the sonic hedgehog pathway is closely related to tumorigenesis in central nervous system. This study aimed to investigate the role of the sonic hedgehog signaling pathway in the occurrence of brainstem and supratentorial glioma.

Methods: Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry were used to detect the expression of sonic hedgehog-related components in 5 specimens of normal brain tissue, 10 of grade II brainstem glioma, and 10 of grade II supratentorial glioma.

[Molecular mechanisms of recurrent venous thrombosis in two pedigrees with type I antithrombin deficiency].

Objective: To investigate the clinical phenotype, genotype and molecular mechanism of recurrent venous thrombosis in two Chinese pedigrees with type I antithrombin (AT) deficiency.

Methods: The routine coagulation screening tests were detected, thrombin generation tests was performed to evaluate the hypercoagulation. Anticardiolipin antibody (ACA) and lupus anticoagulant (LA) were detected with enzyme-linked immunosorbent assay (ELISA) and diluted viper venom time assay (DVVT), respectively.

Hexaaqua-manganese(II) bis-[4-(pyridin-2-ylmeth-oxy)benzoate] dihydrate.

The Mn(II) atom in the title salt, [Mn(H(2)O)(6)](C(13)H(10)NO(3))(2)·2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules. The cations, anions and uncoordinated water mol-ecules are linked by O-H⋯O and O-H⋯N hydrogen bonds into a three-dimensional network. The anion is essentially planar, with an r.

Hexaaqua-cobalt(II) bis-[4-(pyridin-2-yl-meth-oxy)benzoate] dihydrate.

The Co(II) atom in the title salt, [Co(H(2)O)(6)](C(13)H(10)NO(3))(2)·2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules. The cations, anions and uncoordinated water mol-ecules are linked by O-H⋯O and O-H⋯N hydrogen bonds into a three-dimensional network. The anion is essentially planar, with an r.

Metabolic memory: mechanisms and implications for diabetic retinopathy.

Chronic hyperglycemia of diabetes leads to microvascular complications that severely impact quality of life. Diabetic retinopathy (DR) may be the most common of these and is a leading cause of visual impairment and blindness among working age adults in developed nations. Many large-scale type 1 and type 2 diabetes clinical trials have demonstrated that early intensive glycemic control can reduce the incidence and progression of micro and macrovascular complications.

Tetra-kis[diamminesilver(I)] bis-(2-hy-droxy-5-methyl-benzene-1,3-disulfonate) monohydrate.

In the crystal structure of the title salt, [Ag(NH(3))(2)](4)(C(7)H(6)O(7)S(2))(2)·H(2)O, the four independent Ag(I) complex cations all lie on special positions of m site symmetry, as do the two independent 2-hy-droxy-5-methyl-benzene-1,3-disulfonate anions. The Ag(I) cations exist in an almost linear coordination geometry [N-Ag-N = 175.2 (2), 178.

Degradation of organic matter from domestic wastewater with loofah sponge biofilm reactor.

A laboratory-scale oxic biofilm reactor using loofah sponge as support material was carried out to study its start-up characteristics and the optimum operation parameters in removing organic matter and nitrogen from domestic wastewater. It took no more than 10 days to complete microbiological cultivation and acclimation, indicating that the natural loofah sponge was a superior support material compared with some conventional ones. The influence parameter experiments showed that the hydraulic retention time (HRT) had a significant influence on the COD and NH(3)-N removal efficiencies, the average COD and NH(3)-N removal efficiencies were 83.

[Evaluation on health education about schistosomiasis for middle school students in Three Gorges Reservoir areas].

After the implementation of health education about schistosomiasis for the middle school students in Three Gorges reservoir areas, the pass rate of knowledge about the schistosomiasis prevention and control of students increased from 6.3% to 75.6%.

Investigation of the inclusion behavior of chlorogenic acid with hydroxypropyl-β-cyclodextrin.

The inclusion complexation behavior of chlorogenic acid (CGA) with the hydroxypropyl-β-cyclodextrin (HP-β-CD) was investigated in both solution and the solid state by UV-vis and fluorescence spectroscopy, infrared spectroscopy (IR), NMR spectroscopy as well as differential scanning calorimetry (DSC). The experimental results indicate that CGA is able to form an inclusion complex with HP-β-CD. The inclusion complex has a stoichiometry of 1:1 and the formation constant was calculated to be 155.

AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome.

Background: To complement next-generation sequencing technologies, there is a pressing need for efficient pre-sequencing capture methods with reduced costs and DNA requirement. The Alu family of short interspersed nucleotide elements is the most abundant type of transposable elements in the human genome and a recognized source of genome instability. With over one million Alu elements distributed throughout the genome, they are well positioned to facilitate genome-wide sequence amplification and capture of regions likely to harbor genetic variation hotspots of biological relevance.

Expression and significance of P53 protein and MDM-2 protein in human gliomas.

Background: P53 is one of the most studied tumor suppressors in the cancer research, and over 50% of human tumors carry P53 mutations. MDM-2 is amplified and/or overexpressed in a variety of human tumors of diverse tissue origin. The aim of this study was to examine the expression of P53 protein and MDM-2 protein in gliomas, and to investigate the relationship between the expression of the two proteins and the histopathological grades of glioma.