Antagonist Targeting the Species-Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti-H. pylori Infection.

Helicobacter pylori (H. pylori) is a group-1 definite pathogenic carcinogen that infects approximately half of the global population, yet no species-specific chemotherapy has yet been developed. It is previously discovered that H.

Alternate encoder and dual decoder CNN-Transformer networks for medical image segmentation.

Accurately extracting lesions from medical images is a fundamental but challenging problem in medical image analysis. In recent years, methods based on convolutional neural networks and Transformer have achieved great success in the medical image segmentation field. Combining the powerful perception of local information by CNNs and the efficient capture of global context by Transformer is crucial for medical image segmentation.

Development and validation of a HPLC-MS/MS method the determination of genistein and equol in serum, urine and follicular fluid.

Soy isoflavones exert estrogen-like synergistic or antagonistic effects by binding to estrogen receptors, and potentially impact the function of female reproductive system, but their distribution profile in human remains little clarified. To determination of genistein (GEN) and equol (EQ) in human urine, serum and follicular fluid (FF), an analytical method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. The enrichment and clean-up are performed on a solid-phase extraction (SPE) column; the elution is a gradient one, with the mobile phase (A) of 0.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

Global Incidence, Risk Factors, and Temporal Trends of Adrenal Cancer: a systematic analysis of cancer registries.

Objectives: Adrenal gland cancer (AGC) is a rare cancer with a poor prognosis. Studies on this cancer have been limited. This study, for the first time, aims to analyse the global disease burden and trends of adrenal gland cancer in country level and examine lifestyle and socioeconomic risk factors to generate hypotheses.

Effect of lockdown during COVID-19 pandemic on physical endurance among healthy male university students in Wuhan: a retrospective cohort study.

We aimed at investigating the impact of coronavirus disease 2019 (COVID-19) on the time required to complete a 1000-m run and vital capacity (VC) among healthy male students at three universities in Wuhan, China, followed for four years covering the prepandemic (2019), early/late pandemic (2020/2021), and post-pandemic (2022) periods. Demographic information including age, body height/weight, and body mass index (BMI) were also collected. After dividing the participants into four groups based on BMI (i.

Co-benefit of forestation on ozone air quality and carbon storage in South China.

Substantial forestation-induced greening has occurred over South China, affecting the terrestrial carbon storage and atmospheric chemistry. However, these effects have not been systematically quantified due to complex biosphere-atmosphere interactions. Here we integrate satellite observations, forestry statistics, and an improved atmospheric chemistry model to investigate the impacts of forestation on both carbon storage and ozone air quality.

Mechanistic and kinetic understanding of Pb-phosphate biomineralization from humic acid-bound Pb under active growth of phosphate solubilizing Enterobacter aerogenes W6.

Humic acid-bound Pb (HA-Pb), as one of the representative solid-associated Pb species, plays important roles in Pb mobility and toxicity in aqueous environments. Stable Pb-phosphate minerals formation mediated by phosphate solubilizing bacteria (PSB) is a promising approach to immobilizing Pb in contaminated waters. However, the underlying processes and kinetics of Pb-phosphate biomineralization from labile HA-Pb species remain unclear.

Exploring metabolite-mediated links between lipidome and deep vein thrombosis: Insights from Mendelian randomization analysis.

The aim was to investigate the causal relationship between the lipidome and deep vein thrombosis (DVT) while identifying and quantifying the role of metabolites as potential mediators. Two-sample Mendelian randomization (MR) analysis of lipid species (n = 7174) and DVT (6767 cases and 330,392 controls) was performed using pooled data from genome-wide association studies. In addition, we quantified the proportion of metabolite-mediated lipidomic effects on DVT using 2-step MR.

Industrial Foundation Model.

Recently, foundation models (such as ChatGPT) have emerged with powerful learning, understanding, and generalization abilities, showcasing tremendous potential to revolutionarily promote modern industry. Despite significant advancements in various fields, existing general foundation models face challenges in industry when dealing with the data of specialized modalities, the tasks of varying-scenario with multiple processes, and the requirements of trustworthy output, which makes industrial foundation model (IFM) a necessity. This article proposes a system architecture of termed IFMsys, including model training, model adaptation, and model application.

Coumarin-Based Arylpyrazolines: Highly Selective Cu Fluorescent Probes and their AIEE and MFC Properties.

Three novel coumarin-based arylpyrazolines were successfully designed and synthesized. Among them, probe B demonstrated excellent detection capabilities for Cu. According to the fluorescence titration and Job's plot, B could form a complex with Cu in a 2∶1 ratio, the detection limit was 1.

Next-Generation Sequencing-Based In Silico Transgene Integration Profiling Tool Accelerates Cell Line Genetic Characterizations.

Genetic characterization including Southern blot analysis of recombinant Chinese hamster ovary (CHO) cell lines expressing biologics is an essential prerequisite for regulatory submissions. The transposon-based expression system for CHO cell lines enables the insertion of DNA sequences into the genome and has been widely used by the biopharmaceutical industry. The system yields clones that are both highly productive and genetically stable.

Remolding the Interface Stability for Practical Aqueous Zn/I Batteries via Sulfonic Acid-Rich Electrolyte and Separator Design.

The electrolyte-electrode interface plays a crucial role in aqueous Zn/I battery and is largely determined by the properties of electrolyte and separator. Here, the synergistic effect of sulfonic acid-rich electrolyte additive and separator impacts the interface stability of Zn/I batteries is comprehensively investigated using operando synchrotron-based Fourier-transform infrared spectroscopy, cryo-electron microscopy, and in situ spectroscopy. As a case study, a cost-effective additive known as lignosulfonic acid sodium (LAS) and a flexible sulfonated polyether sulfone membrane are employed to facilitate the formation of a stable solid electrolyte interface (SEI) on the Zn anode and effectively suppress the shuttle effect.

Morphological and metabolic changes in Changshan Huyou (Citrus changshan-huyou) following natural tetraploidization.

Background: Polyploids in citrus are generally used to improve crop varieties. Changshan Huyou (Citrus changshan-huyou) is a native citrus species in China that is highly adaptable and has pharmaceutical value. However, the influence in Changshan Huyou following polyploidization remains unclear.

Predictive Modeling of Endograft Limb Occlusion After Endovascular Aneurysm Repair: A Propensity Score Matching Analysis.

Background: Endovascular aneurysm repair (EVAR) is widely used to treat abdominal aortic aneurysm (AAA). However, it carries the risk of complications that often require further interventions. Endograft limb occlusion (ELO), though relatively rare, significantly affects patient outcomes.

Growth behavior of heavy metal sulfide particles: A comparison between gas-liquid and liquid-liquid sulfidation.

Sulfide precipitation is an effective method for treating acidic heavy metal wastewater. However, the process often generates tiny particles with poor settling performance. The factors and mechanisms influencing particle size and settling performance remain unclear.

Copper selenide enhanced magnetic biochar for elemental mercury removal from coal combustion flue gas.

With the rapid development of adsorbents for removal of elemental mercury (Hg) from coal combustion flue gas, the preparation of adsorbents with superior performance, lower cost and environmental friendliness remains an important challenge. An incipient wetness impregnation method followed by in-situ selenization was used to load copper selenide (CuSe) onto the surface of optimal magnetic biochar (OMBC). The results showed that CuSe significantly enhanced the Hg removal performance of the OMBC, and CuSe loading ratio of 10 % (10CuSe/OMBC) had the best Hg removal performance.

Managing Ammonia for Multiple Benefits Based on Verified High-Resolution Emission Inventory in China.

Atmospheric ammonia (NH) has multiple impacts on the environment, climate change, and human health. China is the largest emitter of NH globally, with the dynamic inventory of NH emissions remaining uncertain. Here, we use the second national agricultural pollution source censuses, integrated satellite data, N isotope source apportionment, and multiple models to better understand those key features of NH emissions and its environmental impacts in China.

The associations between PTSD symptom clusters, insomnia, and depressive symptoms in Chinese adolescents with low and high levels of internet addiction: A cross-lagged network analysis.

Objective: The prevalence of COVID-19-related posttraumatic stress disorder (PTSD), depression, and insomnia remains high in Chinese adolescents. Existing research suggests strong links between them and the influence of internet addiction (IA) on their development. This study therefore examined a longitudinal network of these psychological symptoms and explored the influence of IA on them.

Impact of single-port versus three-port video-assisted thoracic surgery lobectomy on postoperative pain and quality of life in early-stage non-small cell lung cancer patients: a meta-analysis.

Objective: This meta-analysis aims to evaluate the impact of these two techniques on postoperative pain and quality of life in early-stage NSCLC patients.

Methods: A comprehensive literature search was conducted in PubMed, Cochrane Library, Web of Science, and CNKI databases. Randomized controlled trials and cohort studies comparing single-port and three-port VATS lobectomy for early-stage NSCLC were included.

Computational study of skyrmion stability and transport on W/CoFeB.

Skyrmions are topologically protected magnetic structures originating from Dzyaloshinbskii-Moriya Interaction (DMI) which can be driven by a spin-polarized current making it a candidate for many different novel spintronic devices. However, the transport velocity is proportional to the size of the skyrmion rendering the effort of miniaturizing spintronics devices useless indicating that it is not possible to realise high-speed transport, small size and low operating current at the same time. One approach to solving the trilemma is to increase the spin Hall angle [Formula: see text], the conversion ratio between charge current and spin current, in the heavy metal layer.

Divergent responses of abundant and rare bacterial communities to environmental variables in highly urbanized coastal regions: N-NO mediates the community assembly and co-occurrence networks.

Understanding how rare and abundant bacterial taxa respond to environmental shifts is essential for predicting microbial community dynamics in highly urbanized estuarine ecosystems, where anthropogenic disturbances and nutrient fluctuations significantly reshape ecological processes. Here, we investigated the responses of rare and abundant bacterial communities to the environments in densely urbanized coastal areas (i.e.

OsOFP9 regulates diverse key traits of rice by integrating multiple plant hormones.

As the staple food for more than half of the world's population, rice requires elite varieties with superior quality and high yield to ensure food security. Agronomic traits, such as grain size, leaf angle, seed dormancy, and germination, will affect rice yield. Identification and cloning of key genes and elucidation of molecular mechanisms regulating these traits expedite rice breeding.

Janus CsPbBr-AgBiS Heteronanocrystals for High-Efficiency Photodetectors.

Heteronanocrystals (HNCs) composed of colloidal lead halide perovskites and chalcogenides always offer unique photoelectric properties. Nevertheless, synthesizing perovskite-chalcogenide HNCs has been a tough challenge due to their completely different growth dynamics. Here, we present an effective strategy to synthesize Janus CsPbBr-AgBiS HNCs by in situ growth of CsPbBr NCs on prepared AgBiS quantum dot (QDs).

Protein lactylation in broiler breast: Insights on occurrence mechanisms and the correlations with meat quality.

This study investigated the effects of lactate levels in broiler breast on protein lactylation modification, meat quality, and their correlation. High lactate injections led to increased lactate levels in both serum and breast muscle, and significantly reduced the values of pH, pH and pH. Additionally, the lactylation levels in breast muscle were increased both post-slaughter and post-mortem.