Publications by authors named "Zhang Kouxing"

Pythiosis, a rare and formidable infectious disease caused by , is characterized by profound uncertainties in achieving definitive diagnoses, suboptimal outcomes, and an exceptionally high mortality rate. Here, we present a rare case of human spinal pythiosis in southern China. With advanced metagenomic sequencing technology, was pinpointed as the causative pathogen.

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Background: Since the outbreak of 2019 coronavirus disease (COVID-19), general practitioners (GPs) have been working in the frontline under psychological and physical pressure. This study aims to evaluate the psychological health, career prospective, attitudes toward educational mode changes, and knowledge about COVID-19.

Methods: An online anonymous questionnaire survey was carried out on GP trainees and GPs from June 2022 to September 2022.

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Delayed graft function (DGF) is a type of acute renal failure that is closely linked to the immune system. The objective of this study is to investigate immune trends during the perioperative period of renal transplantation and compare the variations between patients with DGF and immediate graft function (IGF). A total of 48 kidney transplant patients were enrolled.

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Objective: This study aimed to link intracellular adenosine triphosphate content in CD4 T lymphocytes (CD4 iATP) with sepsis patient mortality, seeking a new predictive biomarker for outcomes and enhanced management.

Methods: 61 sepsis patients admitted to the Intensive Care Unit between October 2021 and November 2022 were enrolled. iATP levels were gauged using whole blood CD4 T cells stimulated with mitogen PHA-L.

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Article Synopsis
  • Antibiotic-resistant Acinetobacter baumannii (A. baumannii) is a major cause of infections in hospitals, particularly in ICU patients with pneumonia caused by carbapenem-resistant A. baumannii (CR-AB).
  • A study of 159 CR-AB pneumonia patients from 2019 to 2021 found that 40 progressed to bacteremia, leading to a significantly higher 28-day mortality rate (47.50% vs. 15.97%).
  • Factors such as elevated C-Reactive protein (CRP), use of continuous veno-venous hemofiltration (CVVH), and antifungal drug use were linked to higher risks of developing bacteremia and increased 28-day mortality for
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Background: Targeting the gut microbiota may become a new therapeutic to prevent and treat sepsis. Nonetheless, the causal relationship between specific intestinal flora and sepsis is still unclear.

Methods: A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genome-wide association study (n = 18,340).

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is a rare fungus-like pathogen that is known to cause pythiosis in mammals with high morbidity and mortality. Identification of the pathogen is essential for timely treatment and rational use of antibiotics. However, is difficult to detect conventional microbiological tests.

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Article Synopsis
  • * In a study, two specific miRNAs (miR-17-5p and miR-193a-5p) showed significant differences in levels in bronchoalveolar lavage fluid (BALF-EVs) between pneumonia patients and controls, indicating their potential in diagnosing pneumonia.
  • * The study suggests that miR-17-5p and miR-193a-5p not only have diagnostic accuracy comparable to procalcitonin but also offer higher specificity, making them promising candidates for early
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Article Synopsis
  • Mechanical ventilation (MV) is crucial in ICUs but prolonged use can lead to complications like ventilator-associated pneumonia, making timely weaning important to avoid risks of reintubation and mortality.
  • A multicenter retrospective cohort study will analyze weaning practices across 17 ICUs in China, focusing on patient outcomes related to the initial reason for MV and factors influencing weaning strategies.
  • The study aims to address the gap in knowledge regarding compliance with weaning guidelines and variations in practices among different centers in China.
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pneumonia (PJP) is an opportunistic fungal infection after renal transplantation, which is always severe, difficult to diagnose, combined with multiple complications and have poor prognosis. We retrospectively analyzed clinical data, including risk factors, diagnosis, treatment and complications of seven clinical cases suffered with severe PJP after renal transplantation in our department in 2019. All the seven recipients were routinely prescribed with PJP prophylaxis after renal transplantation, and six of them suffered acute graft rejection before the infection.

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Introduction: Co-infection pneumonia with () and () is rarely reported in previously healthy patients without HIV infection. The diagnosis of pneumonia of and remains challenging due to its nonspecific clinical presentation and the inadequate performance of conventional diagnostic methods.

Case Report: We report the case of a 44-year-old previously healthy male transferred to our hospital in February 2020 with a 4-month history of productive cough and one month of intermittent fever.

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Coronavirus disease 2019 (COVID-19) is a newly-identified infectious diseases that has rapidly spread throughout the world with rising fatalities with declaration by World Health Organization as the pandemic. Online consultations have been shown to alleviate the pandemic with our study aims to demonstrate whether online consultation can be a solution for acute health crisis. Retrospective analysis of the characteristics of online consultations through two primary care online-consultation platforms during COVID-19 pandemic was performed at the Third Affiliated Hospital of Sun Yat-Sen University, which led the assessment of COVID-19-symptoms patients in Guangzhou.

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Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and ribosome protection. Here, we report the emergence of the plasmid-mediated mobile tigecycline resistance mechanism Tet(X4) in Escherichia coli isolates from China, which is capable of degrading all tetracyclines, including tigecycline and the US FDA newly approved eravacycline.

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Aim: To assess whether elderly patients are prioritized under the emergency triage system in Guangzhou, China.

Methods: This was a cross-sectional survey of clinical data from adult visitors to the emergency department of the Third Affiliated Hospital of Sun Yat-sen University between 1 August 2015 and 31 December 2017. The primary end-point was receiving the first medical service within the target waiting time, which varied according to the triage level of the patient.

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Objective: To evaluate whether patients aged over 70 years old is an independent predictor for prolonging the waiting time, and to know whether the population can be prioritized in the emergency grading system.

Methods: A retrospective analysis was conducted. All the clinical data of adult visitors to the emergency department of the Third Affiliated Hospital of Sun Yat-sen University from January 1st in 2016 to December 31st in 2017 were collected.

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Purpose: The relationship between arterial hyperoxia exposure and clinical outcome is under increasing scrutiny. We therefore performed an update meta-analysis to evaluate the effect of arterial hyperoxia on hospital mortality in critically ill adults.

Methods: We searched relevant articles for trials that investigated the relationship between arterial hyperoxia and mortality in critically ill adults.

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Human CD4 T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4 T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4 T cells by using E7/HLA-DR tetramers constructed with different HLA-DRB1 alleles and extracted the CDR3 amino-acid sequences of TCR α- and β-chains.

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Peptic ulcer bleeding due to primary hyperparathyroidism is extremely rare. We report a case of a 42-year-old male with life-threatening acute upper gastrointestinal bleeding secondary to a duodenal ulcer and a history of kidney stones. Gastroscopic therapy, Billroth II gastrointestinal anastomosis and angiographic embolization were sequentially conducted to arrest the hemorrhage.

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The objective of this study was to estimate the seroprevalence of Toxoplasma gondii infection in 394 patients of intensive care unit (ICU) in a hospital between April 2010 and March 2012 and analyze the association between T. gondii infection and ICU patients according to the species of disease. Toxoplasma serology was evaluated by ELISA method using a commercially available kit.

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Outer membrane vesicles (OMVs) are well-characterized virulence factors produced by Gram-negative bacteria. Here, we isolated two clinical Acinetobacter baumannii strains, the multidrug-resistant A. baumannii (MDRAb) A38 and non-MDRAb 5806.

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The in vivo kinetics of antigen-presenting cells (APCs) in patients with advanced and convalescent tuberculosis (TB) is not well characterized. In order to target Mycobacterium tuberculosis (MTB) peptides- and HLA-DR-holding monocytes and macrophages, 2 MTB peptide-specific CD4(+) T-cell receptor (TCR) tetramers eu and hu were successfully constructed. Peripheral blood (PBL) samples from inpatients with advanced pulmonary TB (PTB) were analyzed using flow cytometry, and the percentages of tetramer-bound CD14(+) monocytes ranged from 0.

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Mitochondrial (mt) genome sequences provide useful markers for investigating population genetic structures, systematics and phylogenetics of organisms. Although Taenia multiceps, T. hydatigena, and T.

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Mycobacterium tuberculosis and Mycobacterium bovis are pathogenic bacterial species in the genus Mycobacterium and the causative agents of most cases of tuberculosis (TB). Detection of M. tuberculosis and M.

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Background: Knowledge of predominant microbial patterns in community-acquired pneumonia (CAP) constitutes the basis for initial decisions about empirical antimicrobial treatment, so a prospective study was performed during 2003-2004 among CAP of adult Chinese urban populations.

Methods: Qualified patients were enrolled and screened for bacterial, atypical, and viral pathogens by sputum and/or blood culturing, and by antibody seroconversion test. Antibiotic treatment and patient outcome were also assessed.

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