Gene expression profiles of Chinese medaka (Oryzias sinensis) primary hepatocytes in response to estrone (E), 17β-estradiol (E) and estriol (E).

The natural estrogens, including estrone (E), 17β-estradiol (E), and estriol (E), are frequently detected in aquatic environment at relatively high levels. The most commonly used biomarkers for estrogens are mainly expressed in the liver of fish. Analyses of the global gene profiling in fish liver cells under estrogens treatment will provide precise toxicogenomic information of the natural estrogens which is still not well known.

Multiband Spectrum Method for Quantifying the Ionic Contribution of Volume Strategy and Filler Strategy: Enhancing the Ionic Transport Channels for Polymeric Solid-State Batteries.

As a promising solution for solid-state batteries with high energy density and safety, understanding the mechanism of fast ion conduction in polymer-ceramic composite solid-state electrolytes (CSEs) is still a challenging task. Herein, we understand the enhanced ion conduction in CSEs using a series of ionic spectra. Ionic insight is extended to ion conduction in CSEs, resolving the mechanism of fast ion migration.

Detection of Nickel Atoms Released from Electrodes in Spark Discharges Using Laser-Induced Fluorescence.

The reduction of greenhouse gas emissions and the effort of carbon neutrality require the improvement of spark-ignition engines in terms of efficiency and capability to operate on renewable fuels. The electrode wear of spark plugs, used for ignition of novel fuels and lean mixtures, emerges as a significant challenge in this transition. Understanding the physical mechanism and influence of spark operation parameters of the wear process is thus important.

Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with Network Pharmacology and Molecular Docking Strategy.

Hypertensive nephropathy (HN) is a prevalent complication of hypertension and stands as the second primary reason for end-stage renal disease. Research in clinical settings has revealed that Yanggan Yishui Granule (YGYSG) has significant therapeutic effects on HN. However, the material basis and action mechanisms of YGYSG against HN remain unclear.

Catalyst Supraparticles: Tuning the Structure of Spray-Dried Pt/SiO Supraparticles via Salt-Based Colloidal Manipulation to Control their Catalytic Performance.

The structure of supraparticles (SPs) is a key parameter for achieving advanced functionalities arising from the combination of different nanoparticle (NP) types in one hierarchical entity. However, whenever a droplet-assisted forced assembly approach is used, e.g.

Integrated neutrophil-to-lymphocyte ratio and handgrip strength better predict survival in patients with cancer cachexia.

Objectives: Systemic inflammation and skeletal muscle strength play crucial roles in the development and progression of cancer cachexia. In this study we aimed to evaluate the combined prognostic value of neutrophil-to-lymphocyte ratio (NLR) and handgrip strength (HGS) for survival in patients with cancer cachexia.

Methods: This multicenter cohort study involved 1826 patients with cancer cachexia.

Bone marrow biopsy in geriatric patients above the age of 85 years: invaluable or unnecessary? A retrospective analysis.

Bone marrow biopsy (BMB) is a well-established diagnostic tool for various hematological, oncological, and other medical conditions. However, treatment options for geriatric patients (pts) facing these diseases are often constrained. In this single-center, retrospective analysis we assessed the diagnostic value of BMB in geriatric pts aged ≥ 85 years and examined its impact on therapeutic decisions.

Genomic surveillance of transmission and virulence in a healthcare setting.

Unlabelled: infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and the genomic determinants of disease outcomes. Across two wards over 6 months, we selectively cultured from patients ( = 384) and their environments.

Inhibition Effect of Pancreatic Exocrine Insufficiency on Immune Checkpoint Inhibitor Treatment in Pancreatic Cancer: A Retrospective Study.

Introduction: Chemotherapy combined with immune checkpoint inhibitors (ChIM) is used to treat advanced pancreatic ductal adenocarcinoma (PDAC). However, the efficacy of ChIM is similar to that of chemotherapy alone.

Methods: To assess potential factors affecting the effectiveness of ChIM, we analyzed the clinical data of 359 patients with PDAC who visited the hospital during June 2017 to December 2022.

Genomic surveillance of transmission and virulence in a healthcare setting.

infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and genomic determinants of disease outcomes. Across two wards over six months, we selectively cultured from patients (n=384) and their environments.

Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of .

is the second most common bacteria associated with urinary tract infections (UTIs) in women. The antimicrobial treatment regimen for uncomplicated UTI is normally nitrofurantoin, trimethoprim-sulfamethoxazole (TMP-SMX), or a fluoroquinolone without routine susceptibility testing of recovered from urine specimens. However, TMP-SMX-resistant has been detected recently in UTI patients, as well as in our cohort.

NEK8 regulates colorectal cancer progression via phosphorylating MYC.

Radiotherapy and chemotherapy remain the mainstay of treatment for colorectal cancer (CRC), although their efficacy is limited. A detailed understanding of the molecular mechanisms underlying CRC progression could lead to the development of new therapeutic strategies. Although it has been established that MYC signaling is dysregulated in various human cancers, direct targeting MYC remains challenging due to its "undruggable" protein structure.

Uncharacterized and lineage-specific accessory genes within the pan-genome landscape.

is a Gram-negative bacterium recognized for its unique swarming motility and urease activity. A previous proteomic report on four strains hypothesized that, unlike other Gram-negative bacteria, may not exhibit significant intraspecies variation in gene content. However, there has not been a comprehensive analysis of large numbers of genomes from various sources to support or refute this hypothesis.

Evaluation of the NG-Test CARBA 5 Lateral Flow Assay with an IMP-27-Producing Morganella morganii and Other .

An isolate of Morganella morganii (MMOR1) that tested susceptible to 3/4-generation cephalosporins and intermediate to meropenem was characterized as positive for NDM and IMP carbapenemases by NG-Test CARBA 5. Our objective was to further investigate this result, given the inconsistent susceptibility profile and unusual epidemiological profile for our region. The MMOR1 isolate was retested for antimicrobial susceptibilities and characterized for carbapenemase production.

Supraparticles for naked-eye H indication and monitoring: Improving performance by variation of the catalyst nanoparticles.

The recent transition to H-based energy storage demands reliable H sensors that allow for easy, fast, and reliable detection of leaks. Conventional H detectors are based on the changes of physical properties of H probes induced by subsurface H-atoms to a material such as electrical conductivity. Herein, we report on highly reactive gasochromic H detectors based on the adsorption of H on the material surface.

Corrigendum: Targeted therapy in cardiovascular disease: A precision therapy era.

[This corrects the article DOI: 10.3389/fphar.2021.

An outbreak of tuberculosis in endangered northern pig-tailed macaques (Macaca leonina) and milu deer (Elaphurus davidianus) from a zoo in China.

Background: Tuberculosis (TB) is a zoonotic disease that affects humans and domesticated and wild animals. Animals in zoos are potentially an important source of TB for humans; however they are often neglected in routine disease surveillance programs. This investigation reports an outbreak of TB in milu deer and northern pig-tailed macaques in a zoo in Wuhan, China, which highlighted the need for improved prevention and control of TB in China.

Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (): A Study from Laboratory to Field.

Fluorene-9-bisphenol (BHPF), a bisphenol A (BPA) substitute, has been increasingly used as a material in syntheses of polymers that are widely used in road markings, artificial tracks, coating floors, building paints, etc., increasing the likelihood of BHPF contamination in the aquatic environment due to its release from the products. However, to date, it is unknown whether it may have actual impacts on fish in real environments.

Toward Stable Al Negative Electrodes of Aluminum-Ion Batteries: Kinetic Parameters and Electrode Structure.

Rechargeable aluminum-ion batteries have attracted significant attention as candidates for next-generation energy storage devices owing to their high theoretical capacity, safe performance, and abundance of raw materials. Al metal is the best option as the negative electrode, while its issues such as dendrite growth and corrosion accompanying hydrogen evolution in ionic liquid electrolyte have been seriously overlooked. Understanding the electrochemical mechanism of the surface evolution behavior of Al metal is a vital pathway for solving these issues.

Understanding Enhanced Ionic Conductivity in Composite Solid-State Electrolyte in a Wide Frequency Range of 10 -10 Hz.

The ionic conductivity of composite solid-state electrolytes (SSEs) can be tuned by introducing inorganic fillers, of which the mechanism remains elusive. Herein, ion conductivity of composite SSEs is characterized in an unprecedentedly wide frequency range of 10 -10  Hz by combining chronoamperometry, electrochemical impedance spectrum, and dielectric spectrum. Using this method, it is unraveled that how the volume fraction v and surface fluorine content x of TiO fillers tune the ionic conductivity of composite SSEs.

New Insights into the Structure and Assembly of Bacteriophage P1.

Bacteriophage P1 is the premier transducing phage of . Despite its prominence in advancing genetics, modern molecular techniques have not been applied to thoroughly understand P1 structure. Here, we report the proteome of the P1 virion as determined by liquid chromatography tandem mass-spectrometry.

Comparative Analysis on Proteomics Profiles of Intracellular and Extracellular and BCG From Infected Human Macrophages.

Tuberculosis is the second cause in infectious diseases leading to human death. Understanding the virulence mechanism is inevitable if the disease needs to be fully cured. Therefore, this study aimed to reveal this mechanism by comparing proteomic profiles of intracellular and extracellular virulent strain and bacille Calmette-Guérin (BCG) from infected THP-1cells.

16.9 W average power from a diode-pumped picosecond Yb:YAG laser with a large-size rectangular core crystalline waveguide.

We demonstrate a high-power all-solid-state picosecond laser based on a passive mode-locking laser with a large-size rectangular core crystalline waveguide and a semiconductor saturable-absorber mirror. An average power of 16.9 W is achieved with a 1.

Small RNA Profiling in Provides Insights Into Stress Adaptability.

encounter a number of environmental changes during infection and respond using different mechanisms. Small RNA (sRNA) is a post-transcriptionally regulatory system for gene functions and has been investigated in many other bacteria. This study used and Bacillus Calmette-Guérin (BCG) infection models and sequenced whole bacterial RNAs before and after host cell infection.