Taraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.

Ethnopharmacological Relevance: Taraxasterol (TAR), a compound highly abundant and easily obtainable from Tibetan medicine Ixeridium gramineum (Fisch.) Tzvel., exhibits a variety of biological effects, including hepatoprotective, anti-inflammatory, and antioxidant activities.

Facile synthesis of high-swelling cyclodextrin polymer for sustainable water purification.

Porous materials are widely used in the adsorption field to sequester pollutants to address the global sustainable water security and water scarcity concerns. However, there are still challenges that limit their industrial application, especially the required rational design and construction of porous structures. Here, we report a high-swelling cyclodextrin polymer (His-CDP) that is facilely synthesized without additional design and templates, to achieve high affinity, non-specific and rapid adsorption of pollutants.

Dynamic graph consistency and self-contrast learning for semi-supervised medical image segmentation.

Semi-supervised medical image segmentation endeavors to exploit a limited set of labeled data in conjunction with a substantial corpus of unlabeled data, with the aim of training models that can match or even exceed the efficacy of fully supervised segmentation models. Despite the potential of this approach, most existing semi-supervised medical image segmentation techniques that employ consistency regularization predominantly focus on spatial consistency at the image level, often neglecting the crucial role of feature-level channel information. To address this limitation, we propose an innovative method that integrates graph convolutional networks with a consistency regularization framework to develop a dynamic graph consistency approach.

The calcium-dependent protein kinase CmaCPK4 regulates sex determination in pumpkin (Cucurbita maxima D.).

Pumpkin (Cucurbita maxima D.) is typically monoecious with individual male and female flowers, and its yield is associated with the degree of femaleness, i.e.

Analysis on the spatiotemporal pattern and driving force of the spatial deviation index of grain and economy in counties in China.

Studying the spatial relationship and driving forces between grain production and economic development in China can assist in the coordinated development of economic growth and grain production in both China and other developing countries. Based on panel data from 2000 to 2019 covering 2018 county-level units in China, this study comprehensively investigated the spatial distribution, spatial differences, dynamic evolution of distribution, and driving factors of China's county-level spatial deviation index of grain and economy (SDIGE) using methods such as the standard deviation ellipse method, the three-stage nested decomposition of Theil index, kernel density estimation, and geographically weighted regression (GWR) model. The results show that (1) from 2000 to 2019, China's SDIGE showed a development trend of "up-down-up," and the highest SDIGE was in the northeast region, the lowest in the east region, and the spatial pattern of "high in the northeast-low in the east coast" was increasingly prominent.

The combination of microwave hyperthermia with TIPE2 impedes the growth of orthotopic colon cancer.

Background: Colon cancer (CC) is the main fatal disease of humans. Microwave hyperthermia (MH) is an adjuvant therapy for diverse cancers. Tumor necrosis factor-α induced protein-8-like 2 (TIPE2) is a tumor suppressor.

Preference reversal in intertemporal decision making.

This study examines asymmetric preference reversals in intertemporal decision-making by comparing gain and loss contexts across choice and bidding tasks. In the gain context, participants preferred smaller, sooner (SS) rewards in choice tasks but assigned higher valuations to larger, later (LL) rewards in bidding tasks. Conversely, in the loss context, they showed a preference for LL options in choice tasks but provided lower bids for SS options.

Enhanced sclerotherapy for vascular malformations: A dual-mechanism approach using in-situ forming PATDs gel.

Vascular malformations are common vascular lesions in infants and seriously affect their health and quality of life. Vascular sclerotherapy is an effective treatment for vascular malformations. However, current sclerosants have difficulty achieving both high efficiency and low toxicity, and their dosing forms make it difficult to achieve long-term retention in the affected blood vessels.

Upward social comparison on network and alcohol dependence in college students: the chain mediation impacts of relative deprivation and anxiety.

Background: Nowadays, contemporary society has placed growing emphasis on the alcohol drinking behavior of college students.

Methods: This study employed a cross-sectional design to assess the relationship between upward social comparison (USC) on network and college students drinking behavior, while exploring the mediation impact of relative deprivation (RD) and anxiety. A total of 329 college students (Mage = 21.

Rare earth element and yttrium behaviour during metabolic transfer and biomineralisation in the marine bivalve Mytilus edulis: Evidence for a (partially) biological origin of REY anomalies in mussel shells.

Rare Earth Elements and Yttrium (REY) are widely used as proxies for environmental conditions and biogeochemical processes, but have also become (micro)contaminants of surface waters worldwide. Soft tissues and shells of mussels are increasingly used in environmental science and geology as bioarchives for REY, but REY fractionation by and in these organisms is still not well understood. We report on the distribution of REY in different compartments of marine M.

Mediating role of immune cells in association between volatile organic compounds and periodontitis: NHANES 2011-2014.

Background: The relationship between humans and volatile organic compounds (VOCs) is a persistent concern due to their widespread sources and high evaporation rates. However, there is currently limited direct evidence linking VOC exposure to the development of periodontitis.

Methods: This cross-sectional study analyzed 1525 participants and 21 urinary VOCs in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, aiming to investigate the relationship between periodontitis risk, assessed by attachment loss (AL) and probing depth (PD) and individual VOCs using logistic regression, quantile regression, and subgroup analysis.

The Relationship Between Family Communication and Adolescent Problematic Internet Use: The Chain Mediation Effects of Loneliness and Depression.

Introduction: Problematic internet use (PIU) is a significant issue during adolescence. It is recognized as a condition for further study in the DSM-5 and may also be a consequence of underlying psychopathologies, as suggested by previous studies. Poor family communication is an important predictor of adolescent PIU.

Single-cell transcriptome analysis reveals status changes of immune cells in chronic kidney disease.

Background And Aims: The immune system plays a crucial role in the development of kidney diseases. Chronic kidney disease (CKD) can lead to various complications, potentially affecting multiple systems throughout the body. Currently, the description of the immune system in human CKD is not comprehensive enough.

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction.

The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole-process repair hydrogel (APF/C/L@dECM) is designed.

Genomic analysis of Zhou8425B, a key founder parent, reveals its genetic contributions to elite agronomic traits in wheat breeding.

High-quality genome information is essential for efficiently deciphering and improving crop traits. Here we report a highly contiguous and accurate hexaploid genome assembly for the key wheat breeding parent Zhou8425B, an elite 1BL/1RS translocation line with durable adult plant resistance (APR) against yellow rust (YR) disease. By integrating HiFi and Hi-C sequencing reads, a 14.

Three-dimensional tracking of organ development in live plants based on plasma membrane dyes at single-cell resolution.

Plant developmental biology necessitates precise three-dimensional (3D) tracking of dynamic processes in live plants, and the 3D imaging technique in developmental bioimaging requires suitable fluorophores to achieve single-cell resolution imaging. Herein, we have designed a series of plasma membrane fluorescent dyes with a number of excellent properties and established a single-cell resolution imaging tool based on these dyes for three-dimensional imaging of various tissues and organs in living plants. The designed plasma membrane fluorescent dyes not only have the advantages of rapid wash-free staining, highly specific targeting, high brightness and high contrast imaging, ultralong imaging time and low biotoxicity, but also effectively avoid the autofluorescence interference of chlorophyll in cells, allowing for the development of a three-dimensional imaging approach of living plant organs with single-cell resolution.

Fate of wastewater trace organic chemicals in vegetated biofiltration systems.

Vegetated biofiltration system (VBS) is an effective green technology for urban stormwater and greywater treatment. However, VBS is yet to be optimised for effective treatment of wastewater, particularly if it contains trace organic chemicals (TrOCs). The effect of plant species has not been addressed under TrOC wastewater loading.

Improved self-training-based distant label denoising method for cybersecurity entity extractions.

The task of named entity recognition (NER) plays a crucial role in extracting cybersecurity-related information. Existing approaches for cybersecurity entity extraction predominantly rely on manual labelling data, resulting in labour-intensive processes due to the lack of a cybersecurity-specific corpus. In this paper, we propose an improved self-training-based distant label denoising method for cybersecurity entity extraction.

Matrix Viscoelasticity Controls Differentiation of Human Blood Vessel Organoids into Arterioles and Promotes Neovascularization in Myocardial Infarction.

Stem cell-derived blood vessel organoids are embedded in extracellular matrices to stimulate vessel sprouting. Although vascular organoids in 3D collagen I-Matrigel gels are currently available, they are primarily capillaries composed of endothelial cells (ECs), pericytes, and mesenchymal stem-like cells, which necessitate mature arteriole differentiation for neovascularization. In this context, the hypothesis that matrix viscoelasticity regulates vascular development is investigated in 3D cultures by encapsulating blood vessel organoids within viscoelastic gelatin/β-CD assembly dynamic hydrogels or methacryloyl gelatin non-dynamic hydrogels.

Modified Magnesium Oxysulfate Foam Cement Doped with Iron Tailings.

The enhancement of the utilization rate of solid waste, along with balancing the comprehensive performance of materials, presents a significant challenge in the development of new functional building materials. This study examined the effects of high concentrations of iron tailing powder on the crystallization characteristics, pore structure, compressive strength, and water absorption of modified magnesium oxysulfate (MOS) foam cement with different dry densities. Furthermore, employing chemical foaming technology, the study characterized and analyzed the microstructure of modified MOS foam cement hydration products through scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD).

DeepEnhancerPPO: An Interpretable Deep Learning Approach for Enhancer Classification.

Enhancers are short genomic segments located in non-coding regions of the genome that play a critical role in regulating the expression of target genes. Despite their importance in transcriptional regulation, effective methods for classifying enhancer categories and regulatory strengths remain limited. To address this challenge, we propose a novel end-to-end deep learning architecture named DeepEnhancerPPO.