Publications by authors named "Zhang Jinlin"
Background: Sepsis is regarded as a dysregulated immune response to infections. Recent study showed partially reversal of immunosuppression by trained immunity, which fosters an enhanced immune response towards a secondary challenge. However, the role of trained immunity in sepsis has not been fully understood.
View Article and Find Full Text PDFThe pursuit to operate photocathodes at high accelerating gradients to increase brightness of electron beams is gaining interests within the accelerator community, particularly for applications such as free electron lasers (FEL) and compact accelerators. Cesium telluride (CsTe) is a widely used photocathode material and it is presumed to offer resilience to higher gradients because of its wider band gap compared to other semiconductors. Despite its advantages, crucial material properties of CsTe remain largely unknown both in theory and experiments.
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- Perennial ryegrass exhibits varying levels of salt tolerance, with genotype P1 identified as salt-sensitive and genotype P2 as salt-tolerant when exposed to 200 mM NaCl.
- Through transcriptomics and metabolomics analyses, researchers found 5,728 differentially expressed genes (DEGs) in response to salt stress, highlighting key genes and pathways that contribute to salt tolerance, such as antioxidant enzyme genes and metabolic pathways related to secondary metabolite biosynthesis.
- The study underscores the prominence of the phenylpropanoid biosynthesis pathway in the salt tolerance of perennial ryegrass, particularly in genotype P2, which showed higher levels of beneficial compounds like flavonoids and anthocyanins.
Background: In medical practice, atrial fibrillation (AF) is intricately associated with heart failure (HF). Currently, ethanol infusion of vein of Marshall (EIVOM) for AF ablation in HF patients remains significantly limited.
Method: This was a non-randomized, single-center, retrospective observational study.
Background: This study aimed to analyze the effect of 3D printing temporary crowns on the single and continuous loss restoration of posterior teeth during secondary implant surgery.
Methods: This study adopted a single-center, randomized, single-blind, parallel-controlled trial design. Thirty patients who were admitted to the Department of Stomatology, Affiliated Hospital of Jiangnan University between January 2020 and February 2023 and who had >2 consecutive missing posterior teeth were implanted with the same implant system.
Peripheral inflammation is closely related to the pathogenesis of sickness behaviors and psychiatric disorders such as anxiety and depression. The circumventricular organs (CVOs) are important brain sites to perceive peripheral inflammatory signals, but few studies have reported their role in inflammation-induced anxiety or depression. Using a mouse model of lipopolysaccharide (LPS)-induced inflammation, we identified a previously unreported role of the subfornical organ (SFO), one of the CVOs, in combating inflammation-induced anxiety.
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- The study investigates whether combining linear ablation and ethanol infusion of the vein of Marshall (EIVOM) with pulmonary vein isolation (PVI) improves maintenance of sinus rhythm in patients with persistent atrial fibrillation (AF).
- Conducted as the PROMPT-AF trial across 12 hospitals in China, it enrolled 498 patients, comparing outcomes between PVI alone and the combined approach.
- Primary outcomes focused on the rate of freedom from atrial arrhythmias without antiarrhythmic drugs within a year, with various secondary outcomes related to arrhythmia recurrence and quality of life also assessed.
Introduction: Eprinomectin offers promise against parasitic infections. This study develops Eprinomectin (EPR) mixed micelles for transdermal delivery, aiming to enhance efficacy and convenience against endoparasites and ectoparasites. Physicochemical characterization and pharmacokinetic studies were conducted to assess its potential as an effective treatment for parasitic infections.
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- Gold nanomaterials are promising for biomedical research due to their unique properties and can be used in nanochips to create high-quality substrates for gold nanoparticles.
- The paper discusses how different optical properties of gold nanostructures, like surface plasmon resonance, surface-enhanced Raman scattering, and fluorescence resonance energy transfer, can enhance the performance of biosensing and diagnostics.
- It also explores the future of in vitro diagnostics by reviewing detection strategies and challenges faced by gold-based diagnostics, offering insights on developing effective gold-based nanobiosensors.
Optimized analysis for related substances in spiramycin based on high performance liquid chromatography with hybrid particle column and characterization of its impurities by single heartcut two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometer.
J Pharm Biomed Anal
January 2025
Article Synopsis
- The article discusses a new method for analyzing spiramycin-related substances using a hybrid particle column and specific chromatographic conditions.
- It employs two different mobile phases for gradient elution, resulting in a method that is characterized by strong specificity, sensitivity, and stability.
- Additionally, six previously unreported impurities above 0.1% were identified using advanced 2D liquid chromatography linked with a mass spectrometer (2D LC-QTOF-MS/MS).
Synthesis of Novel Propionamide-Methylpyrazole Carboxylates as Herbicidal Candidates.
J Agric Food Chem
October 2024
Transketolase (TKL; EC 2.2.1.
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- Epicardial Marshall bundles (MBs) are often involved in left atrial tachycardias (LATs) following atrial fibrillation (AF) ablation, prompting a study to classify various activation patterns and their electrophysiologic traits.
- The research analyzed 28 cases of MB-mediated LATs, identifying three activation patterns: perimitral macroreentry, left atrial appendage-related reentry, and left pulmonary vein-related reentry, with notable electrophysiologic characteristics observed.
- The study concluded that ultrahigh-density mapping effectively distinguishes MB-mediated LATs, and that ethanol infusion in the vein of Marshall can effectively terminate these tachycardias in many patients.
Soil salinization poses a significant global challenge, exerting adverse effects on both agriculture and ecosystems. Planting halophytes has the potential ability to improve saline-alkali land and enhance ecosystem multifunctionality (EMF). However, it remains unclear which halophytes are effective in improving saline-alkali land and what impact they have on the rhizosphere microbial communities and EMF.
View Article and Find Full Text PDFBackground: Radiofrequency catheter ablation (RFCA) has been shown to have low efficacy for the treatment of persistent atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). We conducted this study to evaluate the benefit of adjunctive vein of Marshall (VOM) ethanol infusion during RFCA for persistent AF (PsAF) in patients with non-obstructive HCM.
Methods: This multicenter retrospective observational study included 102 consecutive non-obstructive HCM patients with PsAF who underwent RFCA plus VOM ethanol infusion (VOM-EI) (RFCA + VOM, n = 56) or RFCA alone (RFCA, n = 46) for the first time.
Aim: The aim of this study was to investigate self-care behaviours of patients with chronic obstructive pulmonary disease (COPD), understand their complex interconnections and identify key behaviours influencing self-care and self-efficacy.
Design: An observational, cross-sectional study design.
Setting(s): The outpatient department of two tertiary hospital.
Antimony is pervasive environmental toxic substance, and numerous genes encoding mechanisms to resist, transform and extrude the toxic metalloid antimony have been discovered in various microorganisms. Here we identified a major facilitator superfamily (MFS) transporter, AntB, on the chromosome of the arsenite-oxidizing bacterium Ensifer adhaerens E-60 that confers resistance to Sb(III) and Sb(V). The antB gene is adjacent to gene encoding a LysR family transcriptional regulator termed LysR, which is an As(III)/Sb(III)-responsive transcriptional repressor that is predicted to control expression of antB.
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- * A novel aerosol detector called nano-quantity analyte detector (NQAD) was developed, offering higher sensitivity and a wider linear detection range compared to traditional detectors like ELSD and CAD.
- * The method also included using less toxic ion-pairs in the eluent and involved characterizing the impurities present in ribostamycin through liquid chromatography-mass spectrometry (LC-MS), promising more accurate results for quality control.
Analyzing polysorbate 20 (PS20) composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance. The similar structures and polarities of PS20 components make accurate separation, identification, and quantification challenging. In this work, a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography (HPLC) with charged aerosol detection (CAD) to separate 18 key components with multiple esters.
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- Silicon (Si) is shown to boost crop yields by helping plants resist stress, specifically aiding hyperaccumulators like Sedum alfredii Hance in extracting Cadmium (Cd) from soil.
- The study found that increasing Si concentrations led to higher shoot biomass and Cd accumulation, along with improvements in chlorophyll, carotenoids, and photosynthetic performance.
- Si also reduced oxidative damage by enhancing antioxidant activity, supported Cd chelation in plant cells, and influenced gene expression related to Cd detoxification and transport, suggesting its potential role as a fertilizer for improving phytoextraction.
With the acceleration of industrialization, Cd pollution has emerged as a major threat to soil ecosystem health and food safety. Hyperaccumulating plants like Sedum alfredii Hance are considered to be used as part of an effective strategy for the ecological remediation of Cd polluted soils. This study delved deeply into the physiological, transcriptomic, and metabolomic responses of S.
View Article and Find Full Text PDFBackground: Different types of recurrent atrial tachycardia (AT) after Cox-maze procedures have been reported, whereas biatrial tachycardia (BiAT) has not been systematically analyzed.
Objective: In this study, we retrospectively investigated the electrophysiologic characteristics of BiAT after Cox-maze procedures by use of an ultrahigh-density mapping system.
Methods: Of a consecutive 76 patients who underwent catheter ablation of AT after Cox-maze procedures, 12 BiATs were identified.
Article Synopsis
- Plastic fragments in soil disrupt carbon cycling and reduce soil functionality, forming a noticeable "plastic footprint."
- Research found that these plastic fragments lead to decreased photosynthesis and root carbon fixation, resulting in higher carbon emissions and lower carbon sequestration.
- The study highlights the need to consider plastic pollution in current carbon assessment methods, as it significantly negatively impacts long-term carbon storage in soils.