Alterations in degree centrality and functional connectivity associated with cognitive Impairment in myotonic dystrophy type 1:A Preliminary functional MRI study.

Objectives: The study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in patients with myotonic dystrophy type 1 (DM1).

Methods: Eighteen DM1 patients and eighteen healthy controls participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC and FC analyses were used to assess abnormalities in functional connections among aberrant hubs.

Therapeutic targets in the Wnt signaling pathway: Treating cancer with specificity.

The Wnt signaling pathway is a critical regulatory mechanism that governs cell cycle progression, apoptosis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, and the tumor immune microenvironment, while also maintaining tissue homeostasis. Dysregulated activation of this pathway is implicated in various cancers, closely linked to tumor initiation, progression, and metastasis. The Wnt/β-catenin axis plays a central role in the pathogenesis of common cancers, including colorectal cancer (CRC), breast cancer (BC), liver cancer, and lung cancer.

SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells.

We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols with estrogenic activity (i.e. phytoestrogens).

Manipulating Crystal Packing in Heterocycloarenes by an Atom Engineering Strategy for High-Mobility Organic Field-Effect Transistors.

Developing (hetero)cycloarenes, an emerging class of ring-shaped organic semiconductors (OSCs), for high-performance optoelectronic applications remains significantly constrained due to their synthesis challenge and limited diversity of available materials. Herein, a series of coplanar chalcogen-fused heterocycloarenes NO, NS, and NSe with long branched alkyl chains were synthesized in single-crystal form, and chalcogen atom engineering on heterocycloarenes was investigated in detailed. As a result, sulfur-fused NS exhibits a closest herringbone crystal packing with π-π stacking distance as low as 3.

Altered resting-state functional connectivity of amygdala subregions in adults with subthreshold depression after aerobic exercise.

Aerobic exercise has been proved to reduce the risk of major depression in subthreshold depression (StD) individuals effectively, yet previous studies ignored the different functions of amygdala subregions. In this study, 44 StD individuals and 34 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging before and after eight weeks of aerobic exercise respectively. Transverse and longitudinal analyses were conducted based on the seed-based functional connectivity (FC) analysis between amygdala subregions and the whole brain of the two groups.

Large-scale distribution and ecological risk assessment of inorganic arsenic in surface sediments of Chinese marginal seas.

Chinese marginal seas play a crucial role in sea-land interactions, but there is limited large-scale research on the occurrence and ecological risks of As in these areas. This study employed an extensive investigation on the spatial distribution and fractions of As in surface sediments across all four Chinese marginal seas, encompassing 111 sampling sites. The results revealed that the surface sediments exhibited elevated levels of total As content, surpassing those observed in other marginal seas worldwide.

Manipulating Crystal Packing and Self-Assembly by π-Extended and Isomeric Fused Strategies in Thiophene Ring-Terminated Polycyclic Aromatic Hydrocarbons.

Two series of polycyclic aromatic hydrocarbon isomers ( and , and and ) were designed and synthesized by isomerically fusing phenanthrene with thiophene and thieno[3,2-]thiophene, respectively. All of the new target molecules were confirmed by single-crystal X-ray analysis, and it was found that the solid-state packing can be effectively modulated through a combination of π-extended and isomeric fused strategies. Meanwhile, compared with thiophene ring-terminated isomers and , both having a V-shaped geometry and showing no obvious self-assembly behavior, π-extended unit thieno[3,2-]thiophene-terminated isomer displays a V-shaped structure with moderate self-assembly properties and isomer exhibits a C-shaped configuration with further enhanced self-assembly properties.

RMethyMD: An integrated platform for exploring RNA methylation in pan-cancer via a multiomics analysis.

A user-friendly integrated database, RMethyMD (http://www.tmliang.cn/rnamethy), was developed to provide a comprehensive analysis of methylation regulators aimed at facilitating the exploration of molecular features in tumorigenesis and clinical implications in cancer diagnosis and treatment via a multiomics approach.

The relationship between acute aerobic exercise and inhibitory control in college students: The impact of physical and cognitive engagement.

Objective: Evidence suggests that acute exercise is an effective way for improving inhibition control, however, the effect of different types of Acute Aerobic Exercise and Inhibitory Control (IC) remains unclear.

Method: Using a crossover design, 25 participants (M = 20.20year, SD=0.

The Masculinizing gene is a candidate male pathway developmental factor in the mud crab Scylla paramamosain.

The Masculinizer (Masc) gene plays a crucial role in masculinization during insect embryonic gonadal development. Nevertheless, the Masc expression pattern and function in crabs remain largely unknown. In the present study, we screened and validated the Masc gene from transcriptome data of mud crab S.

Surface-Reconstructed CdNNi Antiperovskite Electrocatalyst: Unlocking Ampere-Level Current Density for Hydrogen Evolution.

Developing conductive electrocatalysts is crucial for decreasing the ohmic loss induced by electric resistance of the catalyst layer in the large-current-density hydrogen evolution reaction (HER), which has been overlooked previously. In this study, we screen a highly conductive antiperovskite CdNNi with negligible ohmic loss, as a highly active and durable HER electrocatalyst capable of unlocking ampere-scale current densities. CdNNi exhibits an impressive activity (an overpotential of 235 mV) at 1 A cm and maintains its performance steadily at an ampere-scale current density (at 1 A cm over 400 h).

Enhanced endoplasmic reticulum stress signaling disrupts porcine sertoli cell function in response to Bisphenol A exposure.

Bisphenol A (BPA), a pervasive substance in our daily lives and livestock excreta, poses significant threats due to its infiltration into foods and water sources. BPA has adverse impacts on male reproductive function, particularly affecting the critical Sertoli (ST) cells that play a pivotal role in the process of spermatogonia differentiating into spermatozoa. In this study, we examined the prevalence of BPA within the pig industry and delved into the impact of BPA exposure on the motility of boar sperm, the function of pig ST cells, as well as the underlying molecular mechanisms involved.

Machine Learning-Aided Discovery of Low-Pt High Entropy Intermetallic Compounds for Electrochemical Oxygen Reduction Reaction.

Advancing the design of cathode catalysts to significantly maximize platinum utilization and augment the longevity has emerged as a formidable challenge in the field of fuel cells. Herein, we rationally design a high entropy intermetallic compound (HEIC, Pt(FeCoNiCu)) for catalyzing oxygen reduction reaction (ORR) by an efficient machine learning stategy, where crystal graph convolutional neural networks are employed to expedite the multicomponent design. Based on a dataset generated from first-principles calculations, the model can achieve a high prediction accuracy with mean absolute errors of 0.

The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies.

The establishment and utilization of preclinical animal models constitute a pivotal aspect across all facets of cancer research, indispensably contributing to the comprehension of disease initiation and progression mechanisms, as well as facilitating the development of innovative anti-cancer therapeutic approaches. These models have emerged as crucial bridges between basic and clinical research, offering multifaceted support to clinical investigations. This study initially focuses on the importance and benefits of establishing preclinical animal models, discussing the different types of preclinical animal models and recent advancements in cancer research.

KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1.

Acute liver failure (ALF) is characterized by the rapidly progressive deterioration of hepatic function, which, without effective medical intervention, results in high mortality and morbidity. Here, using proteomic and transcriptomic analyses in murine ALF models, we found that the expression of multiple splicing factors was downregulated in ALF. Notably, we found that KH-type splicing regulatory protein (KHSRP) has a protective effect in ALF.

Modulated synthesis of hcp MOFs for preferential CO capture.

We herein show that the μ-OH bridging groups in the double MO(OH) clusters of hcp UiO-66 could act as a preferential CO sorption site, compared to fcu UiO-66. As such, hcp-UiO-66-0.015 shows a high binary CO sorption capacity of 0.

Exploring the Role of Clustered Mutations in Carcinogenesis and Their Potential Clinical Implications in Cancer.

Abnormal cell proliferation and growth leading to cancer primarily result from cumulative genome mutations. Single gene mutations alone do not fully explain cancer onset and progression; instead, clustered mutations-simultaneous occurrences of multiple mutations-are considered to be pivotal in cancer development and advancement. These mutations can affect different genes and pathways, resulting in cells undergoing malignant transformation with multiple functional abnormalities.

Aerobic Se(IV) reducing bacteria and their reducing characteristics in estuarine sediment.

Microorganisms play a critical role in the biogeochemical cycling of selenium in natural ecosystems, particularly in reducing selenite (Se(IV)) to element selenium (Se(0)) which reduces its mobility and bioavailability. However, Se(IV)-reducing bacteria and their reducing characteristics in estuarine sediments remain inadequately understood. In this study, the reduction of Se(IV) was confirmed to be microbially driven through the cultivation of a mixture of estuarine sediment and Se(IV) under aerobic conditions.

Tuning Molecular Packing and Boosting Self-Assembling Properties via Ring Fusion Strategy in Naphthalimide-Based A-D-A Conjugated Systems.

Two fully fused acceptor-donor-acceptor (A-D-A) architecture conjugated derivatives ( and ) comprising an electron-withdrawing naphthalimide (NMI) and two different electron-donating cores, phenanthrene and carbazole, respectively, were conveniently synthesized by bismuth(III)-catalyzed selective cyclization of vinyl ethers. Compared with their corresponding single bond-linked A-D-A molecules and , both having a moderately twisted aromatic configuration, the ring fusion strategy leads to fully coplanar conjugated skeletons and greatly changes the electronic structures, photophysical properties, self-assembling behaviors, and molecular packing motifs. In particular, the naphthalimide/carbazole derivative exhibits intriguing 2D brickwork packing and significantly enhanced self-assembling properties.

VO Matrix Confinement Approach to Generate Sub-3 nm L1-Pt-Based Intermetallic Catalysts for Fuel Cell Cathode.

Pt-based intermetallic compounds (IMCs) are considered as a class of promising fuel cell electrocatalysts, owing to their outstanding intrinsic activity and durability. However, the synthesis of uniformly dispersed IMCs with small sizes presents a formidable challenge during the essential high-temperature annealing process. Herein, a facile and generally applicable VO matrix confinement strategy is demonstrated for the controllable synthesis of ordered L1-PtM (M = Fe, Co, and Mn) nanoparticles, which not only enhances the dispersion of intermetallic nanocrystals, even at high loading (40 wt%), but also simplifies the oxide removal and acid-washing procedures.

In Situ Root Dataset Expansion Strategy Based on an Improved CycleGAN Generator.

The root system plays a vital role in plants' ability to absorb water and nutrients. In situ root research offers an intuitive approach to exploring root phenotypes and their dynamics. Deep-learning-based root segmentation methods have gained popularity, but they require large labeled datasets for training.

Improved Transformer for Time Series Senescence Root Recognition.

The root is an important organ for plants to obtain nutrients and water, and its phenotypic characteristics are closely related to its functions. Deep-learning-based high-throughput in situ root senescence feature extraction has not yet been published. In light of this, this paper suggests a technique based on the transformer neural network for retrieving cotton's in situ root senescence properties.

Thin flexible photoacoustic endoscopic probe with a distal-driven micro-step motor for pump-probe-based high-specific molecular imaging.

Conventional photoacoustic endoscopy (PAE) is mostly for structural imaging, and its molecular imaging ability is quite limited. In this work, we address this issue and present the development of a flexible acoustic-resolution-based photoacoustic endoscopic (AR-PAE) probe with an outer diameter of 8 mm. This probe is driven by a micro-step motor at the distal end, enabling flexible and precise angular step control to synchronize with the optical parametric oscillator (OPO) lasers.

Stabilizing Highly Active Ru Sites by Electron Reservoir in Acidic Oxygen Evolution.

Proton exchange membrane water electrolysis is hindered by the sluggish kinetics of the anodic oxygen evolution reaction. RuO is regarded as a promising alternative to IrO for the anode catalyst of proton exchange membrane water electrolyzers due to its superior activity and relatively lower cost compared to IrO. However, the dissolution of Ru induced by its overoxidation under acidic oxygen evolution reaction (OER) conditions greatly hinders its durability.