Survival outcomes of surgery in patients with pulmonary large-cell neuroendocrine carcinoma: a retrospective single-institution analysis and literature review.

Background: Pulmonary large-cell neuroendocrine carcinoma (pLCNEC) is a very rare malignancy originating from the lung and bronchus, and its biological behaviour, clinical diagnosis, treatment and prognosis are poorly understood. Thus, the clinical characteristics and surgical treatment-related prognostic factors of this rare disorder must be explored.

Results: The clinical data of 59 patients (48 males and 11 females) who were treated by surgery and diagnosed with pLCNEC by postoperative pathology at Peking Union Medical College Hospital from April 2004 to April 2019 were analysed retrospectively.

Medial Epicanthoplasty Using a Lower Palpebral Margin Incision Combined With a Tiny Triangular Flap.

Objective: The incidence of epicanthus is extremely high in Asians. Although many techniques have been introduced to remove the epicanthus, there are still some complications. Herein, we introduced a method involving an incision on the lower palpebral margin combined with a tiny triangular flap for correction of epicanthal folds, which is always performed in combination with double eyelid plasty.

FKBP25 Regulates Meiotic Apparatus During Mouse Oocyte Maturation.

FK506 binding proteins 25 (FKBP25) has been shown to function in ribosome biogenesis, chromatin organization, and microtubule stability in mitosis. However, the role of FKBP25 in oocyte maturation has not been investigated. Here, we report that oocytes with FKBP25 depletion display abnormal spindle assembly and chromosomes alignment, with defective kinetochore-microtubule attachment.

Efficacy of opioid receptor modulators in patients with irritable bowel syndrome: A systematic review and meta-analysis.

Background: While irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal diseases in clinical practice, it has diverse pathogenesis. Because of its sudden and lingering intractable symptoms, it seriously affects patients work and life. Opioid receptors are G protein-coupled receptors distributed across the brain, spinal cord, skin, and gastrointestinal tract, and each of the subtypes has a unique role and specific distribution.

Hydrophobic nano SiO as flow-enhancing additives and flame retardant synergizes with CaCO to suppress gas explosion.

The suppression effect of hydrophobic nano SiO of different concentrations as flow-enhancing additives synergizing with CaCO to inhibit gas explosions was systematically studied in a self-built LabVIEW-based explosion test platform. The results showed that the addition of hydrophobic powder can reduce the angle of rest and enhance the flowability of mixed powders, and improve the powder diffusion effect and storability. Meanwhile, changing the proportion and concentration of the mixed powders had a significant impact on the combustion reaction, so that the flame propagation velocity and explosion overpressure decreased significantly.

Improvement of the hydrogen storage characteristics of MgH with a flake Ni nano-catalyst composite.

Magnesium hydride (MgH2) is considered to be one of the most promising hydrogen storage materials owing to its safety profile, low cost and high hydrogen storage capacity. However, its slow kinetic performance and thermal stability limit the possibility of practical applications. Herein, it is confirmed that the hydrogen storage performance of MgH2 can be effectively improved via doping with a flake Ni nano-catalyst.

Robot-Assisted Therapy for Upper Extremity Motor Impairment After Stroke: A Systematic Review and Meta-Analysis.

Objective: The purpose of this study was to review the effects of robot-assisted therapy (RT) for improving poststroke upper extremity motor impairment.

Methods: The PubMed, Embase, Medline, and Web of Science databases were searched from inception to April 8, 2020. Randomized controlled trials that were conducted to evaluate the effects of RT on upper extremity motor impairment poststroke and that used Fugl-Meyer assessment for upper extremity scores as an outcome were included.

Transitioning from donor aid for health: perspectives of national stakeholders in Ghana.

Background: Ghana's shift from low-income to middle-income status will make it ineligible to receive concessional aid in the future. While transition may be a reflection of positive changes in a country, such as economic development or health progress, a loss of support from donor agencies could have negative impacts on health system performance and population health. We aimed to identify key challenges and opportunities that Ghana will face in dealing with aid transition, specifically from the point of view of country-level stakeholders.

Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification.

Background: Ge-Gen-Qin-Lian Decoction (GGQLD), a traditional Chinese medicine (TCM) formula, has been widely used for ulcerative colitis (UC) in China, but the pharmacological mechanisms remain unclear. This research was designed to clarify the underlying pharmacological mechanism of GGQLD against UC.

Method: In this research, a GGQLD-compound-target-UC network was constructed based on public databases to clarify the relationship between active compounds in GGQLD and potential targets.

Identification of lncRNA-mRNA Regulatory Module to Explore the Pathogenesis and Prognosis of Melanoma.

Skin cutaneous melanoma (SKCM) is an aggressive form of skin cancer that results in high mortality rate worldwide. It is vital to discover effective prognostic biomarkers and therapeutic targets for the treatment of melanoma. Long non-coding RNA (lncRNA) has been verified to play an essential role in the regulation of gene expression in diseases and tumors.

Seroprevalence of SARS-CoV-2 infections among children visiting a hospital.

Importance: In this study, we retrospectively investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies within serum samples from children in Beijing, China. These findings provide preliminary guidance regarding population susceptibility to SARS-CoV-2, which will aid in establishing policy toward coronavirus disease 2019 (COVID-19) prevention and control.

Objective: To understand the seropositivity of anti-SARS-CoV-2 IgM/IgG antibodies among children in Beijing, China, evaluate the susceptibility of children in Beijing to SARS-CoV-2, and provide prima facie evidence to guide SARS-CoV-2 prevention and control.

Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa.

As a natural compound isolated from Paeoniae radix, Paeoniflorin (PF) has been shown the antitumor effects in various types of human cancers including glioma, which is one of the serious tumors in central nervous system. Translocator protein 18 KDa (TSPO) has been shown to be relevant to the glioma aetiology. However, the regulation of PF in TSPO and neurosteriods biosynthesis on glioma is still unclear.

Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism.

Context: Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease.

Objective: The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics of valsartan.

Materials And Methods: The pharmacokinetics of valsartan (10 mg/kg) was investigated in Sprague-Dawley rats divided into three groups (with the pretreatment of 4 or 10 mg/kg/day ligustrazine for 10 days and without the pretreatment of ligustrazine as control) of six rats each.

Novel Deep Learning Technique Used in Management and Discharge of Hospitalized Patients with COVID-19 in China.

Purpose: The low sensitivity and false-negative results of nucleic acid testing greatly affect its performance in diagnosing and discharging patients with coronavirus disease (COVID-19). Chest computed tomography (CT)-based evaluation of pneumonia may indicate a need for isolation. Therefore, this radiologic modality plays an important role in managing patients with suspected COVID-19.

Label-free DNAzyme assays for dually amplified and one-pot detection of lead pollution.

Lead pollution in water and soil often transfers to food, advocating tools for on-site detection of lead pollution to ensure both environmental and food safety. We proposed a label-free, dually amplified and homogeneous DNAzyme assay for sensitive and one-pot detection of lead pollution. Instead of using chemically modified DNA substrate, a structure-response digestion process was introduced to monitor Pb presence-induced cleavage process of unlabeled substrate, further amplifying the response signals and eliminating the use of labeled DNA probes.

Understanding the Mechanism between Antisolvent Dripping and Additive Doping Strategies on the Passivation Effects in Perovskite Solar Cells.

Perovskite polycrystalline films contain numerous intrinsic and interfacial defects ascribed to the solution preparation process, which are harmful to both the photovoltaic performance and the stability of perovskite solar cells (PVSCs). Although various passivators have been proved to be promising materials for passivating perovskite films, there is still a lack of deeper understanding of the effectiveness of the different passivation methods. Here, the mechanism between antisolvent dripping and additive doping strategies on the passivation effects in PVSCs is systematically investigated with a nonfullerene small molecule (F8IC).

The Characteristics of Disulfide-Centered Hydrogen Bonds.

The disulfide-centered hydrogen bonds in the three different model systems of diethyl disulfide⋅⋅⋅H O/H CO/HCONH clusters were characterized by high-resolution Fourier transform microwave spectroscopy and quantum chemical computations. The global minimum energy structures for each cluster are experimentally observed and are characterized by one of the three different S-S⋅⋅⋅H-C/N/O disulfide-centered hydrogen bonds and two O⋅⋅⋅H-C hydrogen bonds. Non-covalent interaction and natural bond orbital analyses further confirm the experimental observations.

Effects of virtual reality training on occupational performance and self-efficacy of patients with stroke: a randomized controlled trial.

Background: Virtual reality (VR) has been broadly applied in post-stroke rehabilitation. However, studies on occupational performance and self-efficacy as primary outcomes of stroke rehabilitation using VR are lacking. Thus, this study aims to investigate the effects of VR training on occupational performance and self-efficacy in patients with stroke.

The modulatory effects of bilateral arm training (BAT) on the brain in stroke patients: a systematic review.

Objective: To systematically review the modulatory effects of bilateral arm training (BAT) on the brain of stroke patients in contrast to unilateral arm training (UAT) or regular motor training.

Methods: We conducted a literature search using PubMed, EMBASE, MEDLINE, and Science Citation Index Expanded databases from the inception to March 2019 for identifying any relevant studies. Two authors independently screened the literature, extracted data, and qualitatively described the included studies.

Authentication of emission monitoring data and optimization of desulfurization in the molybdenum roasting process based on BAT-OOPN and the response surface method.

This paper presents a quantitative pollutant discharge model for a typical molybdenum roasting plant, which combines the best available technology and object-oriented Petri net concepts. The proposed model was used to verify whether the best available technology in a molybdenum roasting process meeting the current pollutant emission limits by comparing the results of multiple simulations with online monitoring data records. Theoretical SO emission values were obtained via multiple simulations and compared with the online monitoring data of a typical molybdenum roasting plant to verify the authenticity of the online monitoring data.

Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications.

Aims: Our work aims to revealing the underlying microtubule mechanism of neurites outgrowth during neuronal development and also proposes a feasible intervention pathway for reconstructing neural network connections after nerve injury.

Background: Microtubule polymerization and severing form the basis for neurite outgrowth and branch formation. However, the mechanisms that underlie the dynamic instability of microtubules are unclear.

Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.

Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of cells at key stages.

Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma.

Background: To investigate postoperative temporary consequences of the enrolled patients with lung adenocarcinoma.

Patients And Methods: We analyzed the clinical data of patients with lung adenocarcinoma admitted by the same surgical team of Peking Union Medical College Hospital (PUMCH) from July 2019 to December 2019. Statistical methods including propensity score matching (PSM) analysis was used to analyze the differences among them.

High-Efficient Electrochemiluminescence of BCNO Quantum Dot-Equipped Boron Active Sites with Unexpected Catalysis for Ultrasensitive Detection of MicroRNA.

Herein, the boron radical active sites of boron carbon oxynitride quantum dots (BCNO QDs) are electrically excited to produce boron radicals (B) for catalyzing peroxydisulfate (SO) as a coreactant to accelerate the generation of abundant sulfate radicals (SO) for significant enhancement in the electrochemiluminescence (ECL) efficiency of BCNO QDs, which overcome the defect of traditional carbon-based QDs with low ECL efficiency. Impressively, under extremely low concentration of SO solution, the BCNO QDs/SO system could exhibit high ECL emission, realizing environmental friendliness and excellent biocompatibility for sensitive bioanalysis. As a proof-of-concept, BCNO QDs, a new generation of ECL emitters with high ECL efficiency, were successfully used in the ultrasensitive determination of microRNA-21, which pushes the exploration of new ECL emitters and broadens the application in the field of clinical diagnosis, ECL imaging, and molecular devices.